Update on Clinical Milestone - CytoMed Therapeutics Announces First Patient Dosed in its First-in-Human Phase I Clinical Trial of Allogeneic CAR-Gamma Delta T Cell Therapy in Patients with Advanced Solid Tumours or Haematological Malignancies
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Nov 20 2024
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Should l Buy GDTC?
Source: Newsfilter
CytoMed Therapeutics' Clinical Trial: CytoMed Therapeutics has initiated its first-in-human Phase I clinical trial, known as the ANGELICA Trial, which aims to evaluate the safety and efficacy of allogeneic CAR-T therapy using donor-derived gamma delta T cells for patients with advanced solid tumors and hematological malignancies.
Innovative Approach to CAR-T Therapy: Unlike traditional CAR-T therapies that modify a patient's own blood cells, this trial utilizes blood from eligible donors, potentially lowering production costs and increasing accessibility while avoiding the need for donor-patient compatibility matching.
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About GDTC
CytoMed Therapeutics Limited is a biopharmaceutical company. It is focused on harnessing its licensed proprietary technologies, namely gamma delta T cell and gamma delta Natural Killer T cel to create cell-based immunotherapies for the treatment of human cancers. The development of its technologies has been inspired by the clinical success of existing CAR-T in treating hematological malignancies as well as the clinical limitations and commercial challenges in extrapolating the CAR-T principle into treatment of solid tumors. Its product candidates include CTM-N2D, iPSC-gdNKT, and CTM-GDT. CTM-N2D is a lead product candidate that consists of expanded gamma delta T cells grafted with NKG2DL-targeting CAR to enhance anti-cancer cytotoxicity. The iPSC-gdNKT product candidate utilizes iPSC as a starting material to generate gdNKT, which is a synthetic hybrid of a gamma delta T cell and a NK cell. The Company also has the allogeneic gamma delta T cell technology, namely TCB-002.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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- Technological Focus: The company is focused on developing CAR γδ T cell and iPSC-derived γδ NKT cell therapies to address treatment needs for both blood and solid tumors, showcasing its innovative potential in the biopharmaceutical sector.
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- Technological Advantage: By utilizing donor-derived γδ T cells, CytoMed's therapy circumvents the high costs and logistical complexities associated with autologous treatments, making cancer immunotherapy more accessible and potentially providing a cost-effective option for Malaysian patients.
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See More
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