ProQR Therapeutics CFO Jurriaan Dekkers Steps Down, Dennis Hom To Succeed; Cristina Lopez Named CMO
Management Changes at ProQR Therapeutics: ProQR Therapeutics announced the departure of CFO Jurriaan Dekkers and Chief Corporate Development Officer René Beukema, with Dennis Hom and Cristina Lopez Lopez appointed as new CFO and CMO, respectively.
Focus on Axiomer Technology: The new leadership will guide the company in advancing its Axiomer technology and RNA editing programs as they enter the clinical stage.
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ProQR Forms AI Advisory Board and Partners with Ginkgo Bioworks
- AI Strategy Partnership: ProQR Therapeutics announced the formation of an AI advisory board in collaboration with Ginkgo Bioworks, aiming to leverage artificial intelligence to enhance drug discovery efficiency on its RNA editing technology platform, Axiomer, which is expected to significantly accelerate the R&D process.
- Access to Technology Platform: Through the partnership with Ginkgo, ProQR will gain access to Ginkgo's Nebula, an autonomous lab with over 50 instruments, a move that will eliminate a key bottleneck in AI-enabled drug discovery, thereby enhancing overall R&D capabilities.
- Investment and Development: Ginkgo has made an undisclosed equity investment in ProQR, indicating confidence in ProQR's AI-driven drug discovery initiatives while providing financial support to expedite its R&D efforts.
- Clinical Data Expectations: ProQR plans to report initial clinical data from its inaugural AI-driven drug discovery program by the end of this year, with a clinical trial application expected in mid-2026, marking a significant advancement in its AI drug discovery efforts.
PROQR FORMS AI ADVISORY BOARD AND PARTNERS WITH GINKGO BIOWORKS
Partnership Announcement: ProQR has announced a partnership with Ginkgo BioWorks to enhance its research and development efforts.
Formation of Advisory Board: The collaboration will also involve the formation of an advisory board to guide the partnership's initiatives.
ProQR Reports FY 2025 Financial Highlights
- Earnings Per Share: ProQR reported a GAAP EPS of €0.40 for FY 2025, indicating a level of profitability despite financial challenges, reflecting ongoing investments in R&D and operations.
- Cash Position: As of December 31, 2025, ProQR held approximately €92.4 million in cash and cash equivalents, a significant decrease from €149.4 million in 2024, indicating increased cash outflows in operations and necessitating a focus on future cash management strategies.
- Operating Cash Usage: The net cash used in operating activities for FY 2025 was €52.8 million, up 44% from €36.4 million in 2024, highlighting pressure on operational expenditures that could impact future financial stability.
- R&D Investment Growth: R&D costs for 2025 were €44.7 million, a 23% increase from €36.4 million last year, demonstrating the company's commitment to technological innovation and product development despite high expenditures.
Butterfly Network and Citius Pharma Boost Biotech Activity in After-Hours Trading
Butterfly Network Update: Butterfly Network's shares rose 6.04% after announcing CEO Joseph DeVivo and Interim CFO Megan Carlson will participate in investor meetings at the Evercore Healthcare Conference on December 2, 2025, highlighting their handheld ultrasound technology.
Citius Pharmaceuticals Collaboration: Citius Pharmaceuticals saw a 7.90% increase in shares after announcing a collaboration with Verix to utilize its AI-powered Tovana platform for the U.S. commercialization of LYMPHIR, an FDA-approved immunotherapy for cutaneous T-cell lymphoma.
General Market Activity: ProQR Therapeutics, Perrigo Company, and Tempest Therapeutics also experienced share price increases, with Tempest announcing plans to acquire CAR-T programs to enhance its pipeline.
Other Stocks Performance: Iterum Therapeutics and Processa Pharmaceuticals had minor share price movements without any new updates, reflecting varied investor sentiment in the biotech sector.
VTYX, MEDP, INBX Surge in After-Hours Trading Following Important Announcements
Ventyx Biosciences Surge: Ventyx Biosciences' shares skyrocketed over 88% after positive Phase 2 trial results for its obesity and cardiovascular risk treatment, VTX3232.
Medpace Holdings Performance: Medpace Holdings saw an 18% increase in shares following better-than-expected Q3 results and an updated fiscal year 2025 guidance.
Inhibrx Biosciences Update: Inhibrx Biosciences' shares rose over 10% as the company announced a live webcast to present topline results from its ChonDRAgon study on ozekibart for chondrosarcoma.
Other Notable Movers: Several biotech stocks, including Acumen Pharmaceuticals and SCYNEXIS, experienced significant after-hours gains, reflecting a broader positive trend in the sector.
ProQR Secures CTA Approval for AX-0810 and Plans Virtual Investor and Analyst Event on November 3, 2025
ProQR's Clinical Trial Approval: ProQR Therapeutics has received authorization from the Central Committee on Research Involving Human Subjects (CCMO) for a Phase 1 clinical trial of AX-0810, an investigational RNA editing oligonucleotide targeting NTCP, aimed at treating cholestatic diseases.
Upcoming Investor Event: ProQR will host a virtual event on November 3, 2025, to discuss the safety, pharmacokinetics, and biomarker roadmap for AX-0810, featuring presentations from ProQR management and Professor Henkjan J. Verkade, a key opinion leader in pediatric gastroenterology.
ProQR Forms AI Advisory Board and Partners with Ginkgo Bioworks
- AI Strategy Partnership: ProQR Therapeutics announced the formation of an AI advisory board in collaboration with Ginkgo Bioworks, aiming to leverage artificial intelligence to enhance drug discovery efficiency on its RNA editing technology platform, Axiomer, which is expected to significantly accelerate the R&D process.
- Access to Technology Platform: Through the partnership with Ginkgo, ProQR will gain access to Ginkgo's Nebula, an autonomous lab with over 50 instruments, a move that will eliminate a key bottleneck in AI-enabled drug discovery, thereby enhancing overall R&D capabilities.
- Investment and Development: Ginkgo has made an undisclosed equity investment in ProQR, indicating confidence in ProQR's AI-driven drug discovery initiatives while providing financial support to expedite its R&D efforts.
- Clinical Data Expectations: ProQR plans to report initial clinical data from its inaugural AI-driven drug discovery program by the end of this year, with a clinical trial application expected in mid-2026, marking a significant advancement in its AI drug discovery efforts.
PROQR FORMS AI ADVISORY BOARD AND PARTNERS WITH GINKGO BIOWORKS
Partnership Announcement: ProQR has announced a partnership with Ginkgo BioWorks to enhance its research and development efforts.
Formation of Advisory Board: The collaboration will also involve the formation of an advisory board to guide the partnership's initiatives.
ProQR Reports FY 2025 Financial Highlights
- Earnings Per Share: ProQR reported a GAAP EPS of €0.40 for FY 2025, indicating a level of profitability despite financial challenges, reflecting ongoing investments in R&D and operations.
- Cash Position: As of December 31, 2025, ProQR held approximately €92.4 million in cash and cash equivalents, a significant decrease from €149.4 million in 2024, indicating increased cash outflows in operations and necessitating a focus on future cash management strategies.
- Operating Cash Usage: The net cash used in operating activities for FY 2025 was €52.8 million, up 44% from €36.4 million in 2024, highlighting pressure on operational expenditures that could impact future financial stability.
- R&D Investment Growth: R&D costs for 2025 were €44.7 million, a 23% increase from €36.4 million last year, demonstrating the company's commitment to technological innovation and product development despite high expenditures.
Butterfly Network and Citius Pharma Boost Biotech Activity in After-Hours Trading
Butterfly Network Update: Butterfly Network's shares rose 6.04% after announcing CEO Joseph DeVivo and Interim CFO Megan Carlson will participate in investor meetings at the Evercore Healthcare Conference on December 2, 2025, highlighting their handheld ultrasound technology.
Citius Pharmaceuticals Collaboration: Citius Pharmaceuticals saw a 7.90% increase in shares after announcing a collaboration with Verix to utilize its AI-powered Tovana platform for the U.S. commercialization of LYMPHIR, an FDA-approved immunotherapy for cutaneous T-cell lymphoma.
General Market Activity: ProQR Therapeutics, Perrigo Company, and Tempest Therapeutics also experienced share price increases, with Tempest announcing plans to acquire CAR-T programs to enhance its pipeline.
Other Stocks Performance: Iterum Therapeutics and Processa Pharmaceuticals had minor share price movements without any new updates, reflecting varied investor sentiment in the biotech sector.
VTYX, MEDP, INBX Surge in After-Hours Trading Following Important Announcements
Ventyx Biosciences Surge: Ventyx Biosciences' shares skyrocketed over 88% after positive Phase 2 trial results for its obesity and cardiovascular risk treatment, VTX3232.
Medpace Holdings Performance: Medpace Holdings saw an 18% increase in shares following better-than-expected Q3 results and an updated fiscal year 2025 guidance.
Inhibrx Biosciences Update: Inhibrx Biosciences' shares rose over 10% as the company announced a live webcast to present topline results from its ChonDRAgon study on ozekibart for chondrosarcoma.
Other Notable Movers: Several biotech stocks, including Acumen Pharmaceuticals and SCYNEXIS, experienced significant after-hours gains, reflecting a broader positive trend in the sector.
ProQR Secures CTA Approval for AX-0810 and Plans Virtual Investor and Analyst Event on November 3, 2025
ProQR's Clinical Trial Approval: ProQR Therapeutics has received authorization from the Central Committee on Research Involving Human Subjects (CCMO) for a Phase 1 clinical trial of AX-0810, an investigational RNA editing oligonucleotide targeting NTCP, aimed at treating cholestatic diseases.
Upcoming Investor Event: ProQR will host a virtual event on November 3, 2025, to discuss the safety, pharmacokinetics, and biomarker roadmap for AX-0810, featuring presentations from ProQR management and Professor Henkjan J. Verkade, a key opinion leader in pediatric gastroenterology.
