CytoMed Therapeutics' first-in-human Phase I ANGELICA clinical trial using its patented donor allogeneic chimeric antigen receptor T cell (CAR-T cell) against blood and solid tumors received co-funding support from the NMRC Clinical Trial Grant
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Oct 07 2024
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Should l Buy GDTC?
Source: Newsfilter
CytoMed's ANGELICA Trial: CytoMed Therapeutics has received approval for its first-in-human Phase I clinical trial, the ANGELICA Trial, which utilizes allogeneic CAR-T cell therapy derived from gamma delta T cells to treat various cancers, in collaboration with the National University Hospital of Singapore.
Acquisition and Future Plans: The company has acquired a licensed cord blood bank in Malaysia to enhance its strategy in cell therapies and plans to host an earnings conference call to discuss financial results and future developments.
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About GDTC
CytoMed Therapeutics Limited is a biopharmaceutical company. It is focused on harnessing its licensed proprietary technologies, namely gamma delta T cell and gamma delta Natural Killer T cel to create cell-based immunotherapies for the treatment of human cancers. The development of its technologies has been inspired by the clinical success of existing CAR-T in treating hematological malignancies as well as the clinical limitations and commercial challenges in extrapolating the CAR-T principle into treatment of solid tumors. Its product candidates include CTM-N2D, iPSC-gdNKT, and CTM-GDT. CTM-N2D is a lead product candidate that consists of expanded gamma delta T cells grafted with NKG2DL-targeting CAR to enhance anti-cancer cytotoxicity. The iPSC-gdNKT product candidate utilizes iPSC as a starting material to generate gdNKT, which is a synthetic hybrid of a gamma delta T cell and a NK cell. The Company also has the allogeneic gamma delta T cell technology, namely TCB-002.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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- Sales Growth: The company achieved quarterly sales of $1.047 billion, exceeding the consensus estimate of $1.033 billion, demonstrating robust performance amid strong market demand.
- Stock Surge: Align's shares jumped 10.4% in pre-market trading to $178.13, reflecting a positive investor reaction to the financial results, which may attract more investor interest.
- Increased Market Confidence: This earnings beat not only enhances Align's market image but also potentially supports its future investment and expansion plans, further solidifying its leadership position in the industry.
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- Technological Focus: The company is focused on developing CAR γδ T cell and iPSC-derived γδ NKT cell therapies to address treatment needs for both blood and solid tumors, showcasing its innovative potential in the biopharmaceutical sector.
- Rebuttal of False Claims: CytoMed strongly rejects inaccurate statements regarding its research status and regulatory standing, emphasizing its commitment to compliance and transparency to protect shareholder interests and the company's reputation.
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See More
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- Trial Collaboration Initiated: CytoMed has signed a Memorandum of Understanding with Universiti Malaya Medical Centre to conduct a multi-site first-in-human Phase I clinical trial, aimed at evaluating the safety and efficacy of its patented γδ T cell therapy for no-option cancer patients, marking a strategic expansion into the Southeast Asian market.
- Technological Advantage: By utilizing donor-derived γδ T cells, CytoMed's therapy circumvents the high costs and logistical complexities associated with autologous treatments, making cancer immunotherapy more accessible and potentially providing a cost-effective option for Malaysian patients.
- Clinical Research Backing: Collaborative research with MD Anderson Cancer Center has demonstrated the potential of γδ T cells in treating acute myeloid leukemia, further solidifying the scientific foundation for CytoMed's clinical trials and driving innovation in cancer treatment.
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See More
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- Technological Advantage: CytoMed's γδ T cell therapy utilizes cells derived from healthy donors, avoiding the high costs and complexities associated with autologous therapies, thereby enhancing accessibility for patients, including those from overseas, which presents significant market potential.
- Research Collaboration: CytoMed's partnership with MD Anderson Cancer Center has shown promising results for γδ T cells in treating acute myeloid leukemia, further supporting the application potential of its therapies in cancer treatment and advancing clinical research efforts.
- Strategic Goals: This collaboration with UMMC not only reflects CytoMed's commitment to the Southeast Asian market but also aims to provide more viable treatment options for cancer patients through innovative immunotherapy, aligning with the company's long-term growth strategy.
See More
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Research Publication: CytoMed Therapeutics has published a preclinical study in collaboration with MD Anderson Cancer Center, highlighting the potential of their allogeneic γδ T cell therapy for treating acute myeloid leukemia (AML).
Future Clinical Trials: The company plans to advance its γδ T cell-based products into clinical trials in Southeast Asia, aiming to provide novel immunotherapy options for patients with limited treatment alternatives.
See More
