Butterfly Network and Citius Pharma Boost Biotech Activity in After-Hours Trading
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Nov 24 2025
0mins
Should l Buy CTXR?
Source: NASDAQ.COM
Butterfly Network Update: Butterfly Network's shares rose 6.04% after announcing CEO Joseph DeVivo and Interim CFO Megan Carlson will participate in investor meetings at the Evercore Healthcare Conference on December 2, 2025, highlighting their handheld ultrasound technology.
Citius Pharmaceuticals Collaboration: Citius Pharmaceuticals saw a 7.90% increase in shares after announcing a collaboration with Verix to utilize its AI-powered Tovana platform for the U.S. commercialization of LYMPHIR, an FDA-approved immunotherapy for cutaneous T-cell lymphoma.
General Market Activity: ProQR Therapeutics, Perrigo Company, and Tempest Therapeutics also experienced share price increases, with Tempest announcing plans to acquire CAR-T programs to enhance its pipeline.
Other Stocks Performance: Iterum Therapeutics and Processa Pharmaceuticals had minor share price movements without any new updates, reflecting varied investor sentiment in the biotech sector.
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Analyst Views on CTXR
About CTXR
Citius Pharmaceuticals, Inc. is a biopharmaceutical company focused on the development and commercialization of first-in-class critical care products, with a pipeline of anti-infectives in oncology, adjunct cancer care, stem cell therapy and prescription products. The Company's FDA approved LYMPHIR candidate is a targeted immunotherapy for an initial indication in the treatment of cutaneous T-cell lymphoma. Its late-stage pipeline also includes Mino-Lok, and CITI-002 (Halo-Lido). Mino-Lok is an antibiotic lock solution used to treat patients with catheter-related bloodstream infections (CRBSIs) and central line associated bloodstream infections (CLABSIs). Halo-Lido is a topical formulation of halobetasol propionate, a corticosteroid, and lidocaine that is intended for the treatment of hemorrhoids. The Company is also seeking to develop and commercialize the NoveCite mesenchymal stem cells (NC-iMSCs) to treat acute respiratory conditions with a near term focus on ARDS.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
LYMPHIR Shows Promise in Gynecologic Cancer Treatment
- Clinical Trial Results: The Phase 1 trial led by the University of Pittsburgh demonstrated that LYMPHIR combined with KEYTRUDA showed no unexpected safety signals in 25 patients, indicating a favorable safety profile that could offer new treatment options for difficult-to-treat gynecologic cancers.
- Efficacy Assessment: Among 21 evaluable patients, the combination therapy achieved a 24% objective response rate (ORR) and a 48% clinical benefit rate (CBR), highlighting the potential of this combination to enhance anti-tumor activity and warranting further investigation.
- Market Potential: LYMPHIR is estimated to have a market potential exceeding $400 million, and as demand for novel therapies increases, Citius Oncology's competitive positioning in oncology will be further strengthened, particularly in the ovarian cancer sector where immunotherapy has had limited impact.
- Future Research Plans: Citius Oncology intends to explore the efficacy of LYMPHIR in subsequent Phase 2 studies, and if results are confirmed, it could provide a transformative treatment option for gynecologic cancer patients, significantly improving patient outcomes.
See More
Citius Oncology Reports Positive Phase 1 Trial Results for LYMPHIR in DLBCL
- Clinical Trial Response Rate: The LYMPHIR clinical trial conducted at the University of Minnesota and City of Hope demonstrated an 86% overall response rate, including a 57% complete response and a 29% partial response, indicating the potential efficacy of LYMPHIR in patients with high-risk relapsed DLBCL, which may provide new treatment options in the future.
- Good Safety Profile: LYMPHIR exhibited a favorable safety profile in the trial, with no dose-limiting toxicities observed, laying a solid foundation for its clinical application and potentially enhancing patient acceptance and adherence to treatment.
- Enhancing CAR-T Therapy: The use of LYMPHIR aims to augment the anti-tumor activity of CAR-T cell therapies by improving T-cell depleting effects, which could increase the effectiveness of existing treatment regimens and advance the field of tumor immunotherapy.
- Future Research Directions: The findings set the stage for larger clinical trials, with Citius Oncology planning to further explore the combination of LYMPHIR with other therapies to enhance treatment efficacy and improve long-term patient outcomes.
See More
Citius Oncology Reports Positive Phase 1 Trial Results for LYMPHIR in DLBCL
- Trial Results: The investigator-initiated study of LYMPHIR™ (E7777) at the University of Minnesota and City of Hope demonstrated an overall response rate (ORR) of 86%, including 57% complete responses (CR) and 29% partial responses (PR), indicating its potential efficacy in high-risk relapsed or refractory diffuse large B-cell lymphoma (DLBCL) patients.
- Safety Profile: LYMPHIR was well tolerated in the trial, with no dose-limiting toxicities (DLTs) observed, as all 14 patients completed treatment and proceeded to CAR-T infusion, highlighting its favorable safety profile without any Grade ≥3 immune adverse events reported.
- Treg Depletion Effect: A single dose of LYMPHIR resulted in Treg depletion in nearly all patients, with a median reduction of 24 Tregs/µL, suggesting its potential to enhance standard lymphodepletion regimens and improve the anti-tumor activity of CAR-T therapies.
- Future Research Directions: These findings set the stage for larger studies to assess the potential of LYMPHIR to enhance CAR-T efficacy through prolonged use, further advancing Citius Oncology's strategic positioning in the field of cancer immunotherapy.
See More
Citius Pharmaceuticals Reports $3.9 Million Revenue in Q1 2026
- Revenue Milestone: Citius Pharmaceuticals successfully launched LYMPHIR in December 2025, generating $3.9 million in revenue during Q1 2026, marking a significant transition to a revenue-generating company and reflecting initial success in the cutaneous T-cell lymphoma treatment market.
- Market Potential Assessment: The initial market for LYMPHIR is estimated to exceed $400 million and is underserved by existing therapies, highlighting strategic opportunities and growth potential for Citius in the oncology treatment sector.
- Pipeline Progress: Citius's late-stage pipeline includes Mino-Lok and Halo-Lido, with the former completing a pivotal Phase 3 trial in 2023 and meeting primary and secondary endpoints, which is expected to further drive future revenue growth for the company.
- Financial Stewardship Commitment: The company is committed to financial stewardship to sustain growth momentum while focusing on advancing its late-stage pipeline, aiming to maximize long-term shareholder value through the provision of first-in-class critical care products.
See More
Citius Oncology Reports $3.9 Million in Initial Sales Revenue
- Initial Sales Revenue: Citius Oncology successfully launched LYMPHIR in December 2025, generating $3.9 million in initial sales revenue, marking a pivotal transition from a development-stage organization to a commercial entity, which is expected to significantly enhance future market share and investor confidence.
- Significant Market Potential: The market for LYMPHIR, targeting relapsed or refractory Stage I-III CTCL, is estimated to exceed $400 million and remains underserved by existing therapies, indicating a strategic positioning for long-term growth in the oncology treatment landscape.
- Accelerating Physician Adoption: Since the beginning of 2026, physicians have started initiating patients on LYMPHIR, with the company focusing on accelerating adoption rates and expanding patient access, which will directly drive sales growth and enhance competitive positioning in the market.
- Strategic Investment and Execution: Citius Oncology plans to leverage an advanced AI-enabled commercial platform to support market penetration, with management emphasizing ongoing capital management and evaluation of strategic opportunities to enhance long-term shareholder value, ensuring the company maintains a competitive edge in a rapidly evolving market.
See More
UiPath to Join S&P Midcap 400 Index Effective January 2, 2026
- Market Focus: UiPath Inc. announced it will join the S&P Midcap 400 Index on January 2, 2026, replacing Synovus Financial Corp., a move expected to enhance the company's visibility and investor confidence.
- Stock Price Surge: Following this announcement, UiPath shares rose 6.8% to $17.05 in after-hours trading, reflecting market optimism regarding its future performance.
- FDA Approval: Agios Pharmaceuticals' AQVESME™ (mitapivat) received FDA approval for treating anemia in adults with alpha- or beta-thalassemia, although its stock fell 1.4%, this approval could pave the way for future sales growth.
- Stock Buyback Plan: Ramaco Resources announced a $100 million stock repurchase plan, with shares jumping 7.1% in after-hours trading, indicating the company's confidence in its value and potentially attracting more investor interest.
See More
LYMPHIR Shows Promise in Gynecologic Cancer Treatment
- Clinical Trial Results: The Phase 1 trial led by the University of Pittsburgh demonstrated that LYMPHIR combined with KEYTRUDA showed no unexpected safety signals in 25 patients, indicating a favorable safety profile that could offer new treatment options for difficult-to-treat gynecologic cancers.
- Efficacy Assessment: Among 21 evaluable patients, the combination therapy achieved a 24% objective response rate (ORR) and a 48% clinical benefit rate (CBR), highlighting the potential of this combination to enhance anti-tumor activity and warranting further investigation.
- Market Potential: LYMPHIR is estimated to have a market potential exceeding $400 million, and as demand for novel therapies increases, Citius Oncology's competitive positioning in oncology will be further strengthened, particularly in the ovarian cancer sector where immunotherapy has had limited impact.
- Future Research Plans: Citius Oncology intends to explore the efficacy of LYMPHIR in subsequent Phase 2 studies, and if results are confirmed, it could provide a transformative treatment option for gynecologic cancer patients, significantly improving patient outcomes.
See More
Citius Oncology Reports Positive Phase 1 Trial Results for LYMPHIR in DLBCL
- Clinical Trial Response Rate: The LYMPHIR clinical trial conducted at the University of Minnesota and City of Hope demonstrated an 86% overall response rate, including a 57% complete response and a 29% partial response, indicating the potential efficacy of LYMPHIR in patients with high-risk relapsed DLBCL, which may provide new treatment options in the future.
- Good Safety Profile: LYMPHIR exhibited a favorable safety profile in the trial, with no dose-limiting toxicities observed, laying a solid foundation for its clinical application and potentially enhancing patient acceptance and adherence to treatment.
- Enhancing CAR-T Therapy: The use of LYMPHIR aims to augment the anti-tumor activity of CAR-T cell therapies by improving T-cell depleting effects, which could increase the effectiveness of existing treatment regimens and advance the field of tumor immunotherapy.
- Future Research Directions: The findings set the stage for larger clinical trials, with Citius Oncology planning to further explore the combination of LYMPHIR with other therapies to enhance treatment efficacy and improve long-term patient outcomes.
See More
Citius Oncology Reports Positive Phase 1 Trial Results for LYMPHIR in DLBCL
- Trial Results: The investigator-initiated study of LYMPHIR™ (E7777) at the University of Minnesota and City of Hope demonstrated an overall response rate (ORR) of 86%, including 57% complete responses (CR) and 29% partial responses (PR), indicating its potential efficacy in high-risk relapsed or refractory diffuse large B-cell lymphoma (DLBCL) patients.
- Safety Profile: LYMPHIR was well tolerated in the trial, with no dose-limiting toxicities (DLTs) observed, as all 14 patients completed treatment and proceeded to CAR-T infusion, highlighting its favorable safety profile without any Grade ≥3 immune adverse events reported.
- Treg Depletion Effect: A single dose of LYMPHIR resulted in Treg depletion in nearly all patients, with a median reduction of 24 Tregs/µL, suggesting its potential to enhance standard lymphodepletion regimens and improve the anti-tumor activity of CAR-T therapies.
- Future Research Directions: These findings set the stage for larger studies to assess the potential of LYMPHIR to enhance CAR-T efficacy through prolonged use, further advancing Citius Oncology's strategic positioning in the field of cancer immunotherapy.
See More
Citius Pharmaceuticals Reports $3.9 Million Revenue in Q1 2026
- Revenue Milestone: Citius Pharmaceuticals successfully launched LYMPHIR in December 2025, generating $3.9 million in revenue during Q1 2026, marking a significant transition to a revenue-generating company and reflecting initial success in the cutaneous T-cell lymphoma treatment market.
- Market Potential Assessment: The initial market for LYMPHIR is estimated to exceed $400 million and is underserved by existing therapies, highlighting strategic opportunities and growth potential for Citius in the oncology treatment sector.
- Pipeline Progress: Citius's late-stage pipeline includes Mino-Lok and Halo-Lido, with the former completing a pivotal Phase 3 trial in 2023 and meeting primary and secondary endpoints, which is expected to further drive future revenue growth for the company.
- Financial Stewardship Commitment: The company is committed to financial stewardship to sustain growth momentum while focusing on advancing its late-stage pipeline, aiming to maximize long-term shareholder value through the provision of first-in-class critical care products.
See More
Citius Oncology Reports $3.9 Million in Initial Sales Revenue
- Initial Sales Revenue: Citius Oncology successfully launched LYMPHIR in December 2025, generating $3.9 million in initial sales revenue, marking a pivotal transition from a development-stage organization to a commercial entity, which is expected to significantly enhance future market share and investor confidence.
- Significant Market Potential: The market for LYMPHIR, targeting relapsed or refractory Stage I-III CTCL, is estimated to exceed $400 million and remains underserved by existing therapies, indicating a strategic positioning for long-term growth in the oncology treatment landscape.
- Accelerating Physician Adoption: Since the beginning of 2026, physicians have started initiating patients on LYMPHIR, with the company focusing on accelerating adoption rates and expanding patient access, which will directly drive sales growth and enhance competitive positioning in the market.
- Strategic Investment and Execution: Citius Oncology plans to leverage an advanced AI-enabled commercial platform to support market penetration, with management emphasizing ongoing capital management and evaluation of strategic opportunities to enhance long-term shareholder value, ensuring the company maintains a competitive edge in a rapidly evolving market.
See More
UiPath to Join S&P Midcap 400 Index Effective January 2, 2026
- Market Focus: UiPath Inc. announced it will join the S&P Midcap 400 Index on January 2, 2026, replacing Synovus Financial Corp., a move expected to enhance the company's visibility and investor confidence.
- Stock Price Surge: Following this announcement, UiPath shares rose 6.8% to $17.05 in after-hours trading, reflecting market optimism regarding its future performance.
- FDA Approval: Agios Pharmaceuticals' AQVESME™ (mitapivat) received FDA approval for treating anemia in adults with alpha- or beta-thalassemia, although its stock fell 1.4%, this approval could pave the way for future sales growth.
- Stock Buyback Plan: Ramaco Resources announced a $100 million stock repurchase plan, with shares jumping 7.1% in after-hours trading, indicating the company's confidence in its value and potentially attracting more investor interest.
See More
