AB Science Reports Fourth Consecutive Response for AB8939 and Venetoclax in AML Treatment
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Jan 07 2026
0mins
Should l Buy AB?
Source: Globenewswire
- Significant Efficacy: The combination of AB8939 and Venetoclax has shown a 100% response rate (4/4 patients) in treating acute myeloid leukemia, with one patient achieving near-complete remission within 14 days, indicating strong potential in high-risk populations.
- Good Safety Profile: The treatment exhibited no hematological toxicity or dose-limiting toxicity, demonstrating excellent tolerability, which lays a solid foundation for further clinical research and potential development of this therapy.
- Strong Market Demand: The market potential for treatments targeting relapsed or refractory acute myeloid leukemia exceeds €2 billion annually, and the efficacy of AB8939 could address this unmet medical need, enhancing the company's competitive edge in the field.
- Clinical Trial Progress: The clinical trial for AB8939 has completed its first two stages, and is currently evaluating its combination with Venetoclax, which is expected to provide new treatment options for AML patients and further bolster AB Science's market position.
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Analyst Views on AB
Wall Street analysts forecast AB stock price to rise
4 Analyst Rating
1 Buy
3 Hold
0 Sell
Hold
Current: 40.520
Low
40.00
Averages
42.00
High
46.00
Current: 40.520
Low
40.00
Averages
42.00
High
46.00
About AB
AllianceBernstein Holding L.P. is a global investment management and research company. It provides diversified investment management, research, and related services to a range of clients. It offers Institutional Services to its institutional clients, which include private and public pension plans, foundations and endowments, insurance companies, central banks, and governments worldwide, and affiliates, such as Equitable Holdings, Inc. (EQH) and its subsidiaries. It offers retail services to its retail clients, primarily by means of retail mutual funds sponsored by the Company or an affiliated company, sub-advisory relationships with mutual funds sponsored by third parties, separately managed account programs sponsored by financial intermediaries worldwide and other investment vehicles. It offers Private Wealth Management services to its private clients, including high-net-worth individuals and families, trusts and estates, charitable foundations, partnerships, and other entities.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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AllianceBernstein (AB) Q4 2025 Earnings Transcript
See More
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- Dividend Increase: AllianceBernstein has declared a quarterly dividend of $0.96 per share, marking an 11.6% increase from the previous $0.86, indicating ongoing improvements in profitability and cash flow, which bolsters investor confidence.
- Yield Advantage: The forward yield of 9.05% not only attracts income-seeking investors but also enhances the stock's market appeal, potentially driving up the share price as demand increases.
- Payment Schedule: The new dividend will be payable on March 12, with a record date of February 20 and an ex-dividend date also on February 20, ensuring shareholders receive timely returns and reinforcing shareholder loyalty.
- Market Reaction Expectations: With the dividend increase, the market anticipates that AllianceBernstein will continue to demonstrate strong financial performance, likely attracting more institutional investors and enhancing the company's market position.
See More
AllianceBernstein Reports Q4 2025 Earnings Results
- Earnings Per Unit: AllianceBernstein reported a non-GAAP earnings per unit of $0.96 for Q4 2025, indicating stability amidst market fluctuations, despite a decline compared to the previous year.
- Revenue Performance: The company generated revenue of $957 million, reflecting a year-over-year decrease of 1.7%, highlighting the challenges and pressures faced in the competitive financial services sector.
- Market Outlook: Despite the revenue decline, management's remarks at the Goldman Sachs 2025 U.S. Financial Services Conference suggest an optimistic view of future market prospects, asserting that the company's fundamentals remain intact.
- Executive Appointment: The appointment of Onur Erzan as president is expected to bring new strategic direction and leadership, further enhancing the company's business development and market competitiveness.
See More
AllianceBernstein Reports 2025 Financial Results
- AUM Growth: As of December 31, 2025, AllianceBernstein's assets under management reached $867 billion, reflecting a 9.4% year-over-year increase, demonstrating the company's potential for growth in high-net-worth and private market segments despite client sentiment volatility and net outflows.
- Net Outflows: In 2025, the firm experienced $9.4 billion in active net outflows, primarily driven by $22.5 billion in redemptions from active equities, although the tax-exempt fixed income platform generated $11.6 billion in net inflows, indicating varying demand across asset classes.
- Earnings and Distributions: Adjusted earnings per unit for 2025 grew by 2% to $3.33, while cash distribution per unit was $0.96, reflecting a decrease from the previous year but still showcasing the company's commitment to shareholder returns.
- Operational Efficiency Improvement: The adjusted operating income increased by 4% in 2025, with operating margins rising to 33.7%, indicating positive progress in cost control and operational efficiency, thereby enhancing profitability in a competitive market.
See More
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- Historical Performance: Over the past two years, AllianceBernstein has beaten EPS estimates 75% of the time and revenue estimates 100% of the time, indicating strong earnings resilience and market adaptability.
- Estimate Revision Trends: In the last three months, EPS estimates have seen one upward revision and three downward revisions, while revenue estimates have not been revised upward and have experienced two downward adjustments, suggesting a cautious market outlook on the company's future performance.
- Market Attention: AllianceBernstein's participation in the Goldman Sachs 2025 U.S. Financial Services Conference has heightened market interest in its future developments, particularly in light of its performance in the current economic climate.
See More
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- Portfolio Overview: The Pelosi couple has a net worth of approximately $275 million, primarily derived from successful stock investments, particularly in large-cap tech stocks, highlighting their long-term success and influence in the investment arena.
- Transaction Details: In January 2026, the Pelosis exercised 50 call options to purchase 5,000 shares of tech giants like Alphabet, Amazon, and Nvidia, indicating their strong bullish outlook on these companies, which is expected to drive future investment returns.
- AI Investment Theme: Their investment strategy revolves around 'betting big on AI,' particularly in companies like Tempus AI and Vistra, the latter of which signed a 20-year power purchase agreement with Meta Platforms, reflecting confidence in AI growth potential.
- Investment Performance: From January 2025 to January 2026, the stocks invested by the Pelosis performed exceptionally well, with Alphabet rising 74.6% and Tempus AI soaring 121%, resulting in an overall portfolio return of approximately 41.7%, significantly outperforming the S&P 500 index's 20.3%.
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