QSI News & Events

Quantum-Si Incorporated announced a new manuscript available via pre-print on bioRxiv from researchers out of the University of British Columbia and the B.C. Cancer Research Institute. In the pre-print titled "Heterologous expression of the human cohesin complex in Saccharomyces cerevisiae results in a dominant-negative phenotype", the researchers expressed key human chromosome-organizing proteins in yeast cells. They hypothesized that the human cohesins were forming complexes and disrupting the activity of endogenous yeast cohesins. This matters for cancer drug development because problems with cohesin can drive genome instability in tumors, pointing to new ways to target cancer cells. "We are excited to see the first manuscript published by international researchers," said Jeff Hawkins, President and Chief Executive Officer of Quantum-Si. "In this study, single-molecule protein sequencing enabled the researchers at University of British Columbia and B.C. Cancer Research Institute to directly identify hybrid cohesin complexes, demonstrating the value of our technology as a foundational tool for mechanistic biology research and therapeutic discovery."

Quantum-Si has completed the sequencing of multiple samples provided by an existing Platinum Pro customer on a Proteus prototype system. The testing included sequencing the samples on both Platinum Pro and a Proteus prototype system. For Platinum Pro, the Company used the commercially available Version 3 Library Preparation Kit and Version 4 Sequencing Kit. For the Proteus prototype, the Company used the Version 3 Library Preparation Kit and a developmental sequencing kit that contains the latest amino acid recognizer set. The sequencing results were consistent with the information that the Company shared at the November 2025 Investor and Analyst Day demonstrating that Proteus was far exceeding Platinum Pro performance across all relevant metrics. Specifically, the Proteus prototype and developmental sequencing kit demonstrated significantly improved amino acid coverage, longer read lengths, more peptides identified and greater sequencing output even when normalized for the difference in the number of nanowells on a Platinum Pro chip versus the Proteus KinetIQ array. "We are very excited to have successfully completed the sequencing of our first customer samples on the Proteus prototype system," said Jeff Hawkins, CEO. "Being able to demonstrate that the Proteus prototype system exceeds Platinum performance across all metrics on real world samples is an important milestone in the development of this new platform. We expect sequencing performance to continue to increase from here as we work to further optimize the Proteus system into our final commercial offering. This is just one of many customers who have indicated interest in providing samples for sequencing on the Proteus prototype. We are working closely with our manufacturing partners to increase the rate of delivery of integrated Proteus systems to meet both internal R&D demand and provide additional capacity to be able to offer customer sample testing to the market through a formal pre-launch sample evaluation program. We look forward to providing more updates on this program on our next earnings call."