
KPTI Earnings
Karyopharm Therapeutics Inc
- Overview
- Forecast
- Valuation
- Earnings
Earning Analysis
Welcome to our in-depth analysis of Karyopharm Therapeutics Inc(KPTI) earnings, offering investors a detailed look into the company’s financial performance, revenue trends, earnings per share (EPS), and market reactions. This page provides a comprehensive overview of Karyopharm Therapeutics Inc earnings history, forecasts, and key financial metrics, empowering you with the data needed to make informed investment decisions. Whether you're tracking quarterly results, analyzing earnings surprises, or exploring future projections, our detailed breakdown covers it all.
Earnings Forecast
Revenue
EPS
Currency: USD
Actual
Estimate
Surprise Analysis
FY2025Q2 | 2025-08-11 | Pre-Market | -3.80 | -4.32 | -13.68 | 37.93M | 37.93M | +0.01 | -4.31 | - |
FY2025Q1 | 2025-05-12 | After Hours | -4.21 | -2.77 | +34.20 | 35.12M | 30.02M | -14.54 | -20.00 | -13.50 |
FY2024Q4 | 2025-02-19 | Pre-Market | -0.26 | -0.24 | +7.69 | 35.67M | 30.54M | -14.39 | -4.76 | -9.38 |
FY2024Q3 | 2024-11-05 | Pre-Market | -0.27 | -0.26 | +3.70 | 37.92M | 38.78M | +2.27 | -9.32 | -1.18 |
FY2024Q2 | 2024-08-06 | - | -0.29 | -0.20 | +31.03 | 36.21M | 42.79M | +18.15 | -3.56 | -6.43 |
FY2024Q1 | 2024-05-08 | - | -0.33 | -0.32 | +3.03 | 34.47M | 33.13M | -3.91 | -7.27 | -0.91 |
FY2023Q4 | 2024-02-29 | - | -0.29 | -0.36 | -24.14 | 33.62M | 33.75M | +0.39 | -12.78 | - |
FY2023Q3 | 2023-11-02 | - | -0.28 | -0.30 | -7.14 | 37.40M | 36.01M | -3.73 | -3.18 | -4.58 |
FY2023Q2 | 2023-08-02 | - | -0.34 | -0.29 | +14.71 | 35.67M | 37.58M | +5.36 | -0.56 | -8.33 |
- | 2023-05-04 | - | -0.34 | -0.30 | +11.76 | - | - | - | -24.32 | -26.23 |
KPTI Earnings Analysis
Our earnings analysis provides a granular look at the company’s performance across recent fiscal quarters, highlighting key metrics such as revenue, EPS, and operating margins. By examining actual results against analyst estimates, we uncover trends and surprises that drive stock price movements, offering valuable insights for both short-term traders and long-term investors.
In the most recent quarter, Karyopharm Therapeutics Inc reported performance for FY2025Q2, announced on 2025-08-11. The company achieved an EPS of -4.32, compared to analyst estimates of -3.80 by -13.68% . Revenue for the quarter reached 37.93M compared to expectations of 37.93M by 0.01% .
The stock price reacted with a -4.31% one-day change and a % five-day change following the earnings release. These movements reflect market reaction in Karyopharm Therapeutics Inc growth trajectory and strategic initiatives.
KPTI Earnings Forecast
Looking ahead, Karyopharm Therapeutics Inc(KPTI) remains a focal point for investors seeking growth opportunities. Analyst forecasts for 2025/Q3 project quarter revenue of 39.56M and an EPS of -2.74.
However, recent estimate revisions provide additional context. Over the past three months, revenue estimates for FY2025 have been Revise Downward by -0.53%, while EPS estimates have been Revise Downward by -1.75%. For the upcoming Q2 2025, revenue estimates have been adjusted Revise Downward by -1.61% . These revisions correlate with a -9.55% change in stock price over the same period, suggesting potential buying opportunities for investors who believe in Karyopharm Therapeutics Inc long-term fundamentals.
The relationship between earnings forecast revisions and stock price movements is critical for investors. Positive revisions in revenue or EPS often signal strengthening fundamentals, making temporary price dips attractive entry points. Conversely, downward revisions may reflect short-term challenges.
Estimate Revision
The chart shows the correlation between KPTI's stock price and earnings forecast revisions. Positive revisions in Revenue or EPS often strengthen the stock's fundamentals, making price dips potential buying opportunities.
Revenue Estimates for FY2025
Revise Downward

-0.53%
In Past 3 Month
EPS Estimates for FY2025
Revise Downward

-1.75%
In Past 3 Month
Revenue Estimates for Q2 2025
Revise Downward

-1.61%
In Past 3 Month
Stock Price
Go Down

-9.55%
In Past 3 Month
1Y
3Y
5Y
Annual FY 2025
Currency: USD
1Y
3Y
5Y
--
Revenue Estimate-Annual FY 2025:147.08M
--
EPS Estimate-Annual FY 2025:-11.13
—
Stock Price4.45
KPTI Revenue and EPS Performance: A Historical Perspective
Karyopharm Therapeutics Inc revenue and earnings per share (EPS) performance over recent quarters provides a clear picture of its financial health. Below is a detailed breakdown of the company’s earnings history, showcasing actual results, analyst estimates, and surprise percentages for key fiscal quarters:
FY2025Q2 (2025-08-11,Pre-Market):
EPS: -4.32 (Actual) vs.-3.80 (Estimate) (-13.68%)
Revenue: 37.93M (Actual) vs. 37.93M (Estimate) (0.01%)
Price Reaction: -4.31%(1-Day), %(5-Day)
FY2025Q1 (2025-05-12,After Hours):
EPS: -2.77 (Actual) vs.-4.21 (Estimate) (34.20%)
Revenue: 30.02M (Actual) vs. 35.12M (Estimate) (-14.54%)
Price Reaction: -20.00%(1-Day), -13.50%(5-Day)
FY2024Q4 (2025-02-19,Pre-Market):
EPS: -0.24 (Actual) vs.-0.26 (Estimate) (7.69%)
Revenue: 30.54M (Actual) vs. 35.67M (Estimate) (-14.39%)
Price Reaction: -4.76%(1-Day), -9.38%(5-Day)
Earnings Reaction
The chart below shows how KPTI performed 10 days before and after its earnings report, based on data from the past quarters. Typically, KPTI sees a +11.86% change in stock price 10 days leading up to the earnings, and a -5.73% change 10 days following the report. On the earnings day itself, the stock moves by -6.78%. This data can give you a slight idea of what to expect for the next quarter's release.
For example, in JUN/2025, the stock changed 6.63% on the day following the earnings release and then changed by 18.04% over the next 10 days. These patterns provide investors with valuable insights into potential price movements and help inform trading strategies around earnings events.
Transcript Summary
Karyopharm Therapeutics Inc (KPTI) Q2 2025 Earnings Call Summary
Neutral
2025-08-11
The earnings call reflects a mixed sentiment. While the company reports decreased R&D and SG&A expenses, an increase in interest expense and a significant net loss raise concerns. The Q&A highlights management's optimism about future trials, yet lacks specifics on enrollment and liquidity strategies. The positive outlook on new data readouts and potential market opportunities is tempered by financial challenges. These mixed signals suggest a neutral impact on stock price, with no strong catalysts for a significant move in either direction.
Karyopharm Therapeutics Inc (KPTI) Q1 2025 Earnings Call Summary
Negative
2025-05-13
The earnings call presents a concerning picture with declining revenues, increased product returns, and cash flow risks. Despite passing a futility analysis, clinical trials face enrollment challenges. The lack of a shareholder return plan adds to the negative sentiment. While there is some growth in multiple myeloma, competitive pressures and supply chain issues pose risks. Management's vague responses on cash runway and future risks further contribute to uncertainty. Overall, the sentiment leans negative due to financial instability and competitive market pressures.
Karyopharm Therapeutics Inc. (KPTI) Q3 2024 Earnings Call Summary
Negative
2024-11-06
The earnings call reveals mixed financial performance with a slight revenue increase but declining cash reserves. Regulatory risks, competitive pressures, and supply chain challenges pose significant threats. The Q&A section indicates some positive clinical trial progress but lacks clarity on key metrics. Guidance remains unchanged, and no new partnerships were announced. These factors, combined with the absence of strong catalysts, suggest a negative stock price movement in the short term, particularly with financial stability concerns and competitive pressures in key markets.
People Also Watch

USAU
US Gold Corp
11.900
USD
-4.49%

JSPR
Jasper Therapeutics Inc
2.970
USD
+4.21%

SPWH
Sportsmans Warehouse Holdings Inc
3.060
USD
-2.55%

IROQ
IF Bancorp Inc
25.100
USD
+0.20%

DGICB
Donegal Group Inc
14.400
USD
+0.98%

IKNA
ImageneBio Inc
17.640
USD
+4.20%

ESP
Espey MFG & Electronics Corp
47.490
USD
+2.73%

CHCI
Comstock Holding Companies Inc
15.100
USD
+2.37%

CUE
Cue Biopharma Inc
0.810
USD
+2.53%

TLSA
Tiziana Life Sciences Ltd
2.130
USD
-4.27%
FAQ

What were the key highlights of KPTI’s latest earnings report for FY2025Q2?
KPTI reported its FY2025Q2 earnings on 2025-08-11, showcasing a revenue of 37.93M against an estimate of 37.93M, resulting in a 0.01% surprise. The EPS was -4.32, surpassing the expected -3.8 by -13.68% . The stock experienced a -4.31% price change on the earnings day and a 0% change over the next five days, reflecting market reactions to the results.

How did KPTI’s stock price react after the FY2025Q2 earnings release?

What are the revenue and EPS estimates for KPTI for 2025/Q3?

How does KPTI’s stock price correlate with earnings forecast revisions?

What should investors expect from KPTI’s next earnings report?
