The chart below shows how ARWR performed 10 days before and after its earnings report, based on data from the past quarters. Typically, ARWR sees a +1.75% change in stock price 10 days leading up to the earnings, and a -1.32% change 10 days following the report. On the earnings day itself, the stock moves by -0.17%. This data can give you a slight idea of what to expect for the next quarter's release.
Positive
Collaboration Agreement Impact: Arrowhead Pharmaceuticals closed a significant collaboration agreement with Sarepta Therapeutics, resulting in an expected total of $1,375,000,000 in cash payments, including a $500,000,000 upfront payment and potential milestone payments exceeding $11,000,000,000.
FDA Drug Application Acceptance: The FDA accepted the new drug application for Plazasiran, marking Arrowhead's first NDA filing, with a PDUFA action date set for 11/18/2025, indicating a potential launch for this investigational drug for familial chylomicronemia syndrome.
Triglyceride Reduction Efficacy: Plazasiran demonstrated an approximately 80% reduction in triglycerides from baseline in the Phase III PALISADE study, with over 50% of patients achieving triglyceride levels below 500 mg/dL, significantly reducing the risk of acute pancreatitis.
Phase III Enrollment Progress: Arrowhead is on track to complete enrollment for multiple Phase III studies (SHASTA-3, SHASTA-4, and MIRROR-3) this year, which will enable study completion in 2026 and subsequent supplemental NDA filings, broadening the market potential for Plazasiran.
Future Cash Balance Projection: The company anticipates a cash balance of approximately $1,000,000,000 by the end of 2025, providing a strong financial runway into 2028, supporting ongoing development and commercialization efforts.
Negative
Q1 FY2025 Net Loss: Net loss for Q1 FY2025 was $173.1 million, or $1.39 per share, compared to a net loss of $132.9 million, or $1.24 per share, in Q1 FY2024, indicating a worsening financial position.
Q1 Revenue Decline: Revenue for Q1 FY2025 decreased to $2.5 million from $3.6 million in Q1 FY2024, reflecting a decline in collaboration agreement revenues.
Operating Expenses Increase: Total operating expenses increased to $163.9 million in Q1 FY2025 from $140.1 million in Q1 FY2024, driven by higher candidate costs and salaries as the pipeline expanded.
Operating Cash Flow Increase: Net cash used in operating activities rose to $146.3 million in Q1 FY2025 from $117.8 million in Q1 FY2024, primarily due to increased research and development expenses.
Liquidity Concerns Ahead: Despite a cash balance of $552.9 million at the end of Q1 FY2025, the company anticipates needing additional capital to support ongoing and future clinical trials, indicating potential liquidity concerns.
Earnings call transcript: Arrowhead Pharma misses Q1 2025 forecasts
ARWR.O
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