Werewolf Therapeutics announces Q3 earnings per share of 36 cents, below consensus estimate of 38 cents.
Progress on PREDATOR Platform: Werewolf is advancing its proprietary PREDATOR platform, focusing on its lead clinical programs, WTX-124 and WTX-330, as well as the first INDUCER T-cell engager candidate, WTX-1011.
Updates on Clinical Trials: An update on WTX-124, which has received Fast Track Designation, is expected in Q4 2025, along with information on the Phase 1b/2 trial of WTX-330 and the development plan for this program.
FDA Engagement: The company plans to share insights from an End of Phase 1 meeting with the FDA regarding WTX-124, based on interim clinical trial data.
IND-enabling Studies: Werewolf is making progress in IND-enabling studies for WTX-1011 and aims to nominate a differentiated target candidate by the end of the year.
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GH Research (GHRS) Stock Surges 22.36% Ahead of Key Update
- Stock Surge: GH Research PLC's stock surged 22.36% to $16.20, gaining $2.96, primarily driven by investor anticipation for a key company update scheduled for January 5, 2026.
- Key Update Announcement: The company will disclose the status of its Investigational New Drug Application (IND) for GH001 and progress on its global pivotal Phase 3 program for treatment-resistant depression (TRD), which is expected to have significant implications for the treatment landscape.
- Investor Interest Spike: The strong investor interest surrounding the upcoming announcement has led to a substantial increase in GH Research's stock price, reflecting heightened market confidence in the biotech sector.
- Positive Market Reaction: Despite no new updates from other biotech firms like Phathom Pharmaceuticals and Forte Biosciences, their stock prices also rose, indicating a broader optimistic sentiment in the biotechnology industry.

Werewolf Reports 30% Response Rate for WTX-124 Monotherapy in Melanoma Patients
- Clinical Data Highlight: WTX-124 demonstrated a 30% overall response rate as a monotherapy in post-ICI advanced melanoma patients, indicating its potential as a best-in-class tolerability drug.
- Efficacy Validation: Initial data from WTX-330 further confirmed its antitumor activity and favorable tolerability, building on the first-in-human trial, showcasing its prospects in challenging tumor types.
- Future Development Plans: The Phase 1/1b trial for WTX-124 is expected to complete in the first half of 2026, with additional data updates planned, potentially requiring further funding to initiate a registration trial.
- Strategic Partnership Opportunities: Werewolf is seeking strategic partners to advance the WTX-124 and WTX-330 INDUKINE programs, leveraging its unique INDUCER T cell engager platform to enhance market competitiveness.









