Verastem Discontinues RAMP 203 Trial to Focus on VS-7375 Development
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Dec 29 2025
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Source: Newsfilter
- Clinical Trial Adjustment: Verastem Oncology has announced the discontinuation of the RAMP 203 clinical trial to focus on the development of VS-7375, which has shown a 69% response rate in KRAS G12D non-small cell lung cancer, indicating its potential in treatment.
- Resource Reallocation: This decision reallocates resources from RAMP 203 to VS-7375, aiming to enhance treatment outcomes for patients with advanced lung cancer, reflecting the company's strategic emphasis on new drug development.
- Patient Continuation Option: Patients currently enrolled in the RAMP 203 trial will have the option to continue treatment at the investigator's discretion, a measure aimed at mitigating the risk of treatment interruption for patients due to the trial's discontinuation.
- Market Competition Dynamics: As the treatment standards for KRAS G12C inhibitors evolve, Verastem's strategic adjustment demonstrates its pursuit of greater competitiveness and patient impact in the rapidly changing oncology market.
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Analyst Views on VSTM
Wall Street analysts forecast VSTM stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for VSTM is 15.60 USD with a low forecast of 14.00 USD and a high forecast of 20.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.
6 Analyst Rating
6 Buy
0 Hold
0 Sell
Strong Buy
Current: 6.230
Low
14.00
Averages
15.60
High
20.00
Current: 6.230
Low
14.00
Averages
15.60
High
20.00
About VSTM
Verastem, Inc. is a late-stage development biopharmaceutical company, which focuses on the development and commercialization of new medicines to improve the lives of patients diagnosed with ras sarcoma (RAS)/ mitogen-activated pathway kinase (MAPK) pathway-driven cancers. Its product candidates include avutometinib and defactinib. Avutometinib is an oral RAF/MEK clamp that inhibits MEK1/2 kinase activities and induces inactive complexes of MEK with A-Raf proto-oncogene, potentially serine/threonine kinase (ARAF), B-Raf proto-oncogene serine/threonine kinase (BRAF) and C-raf proto-oncogene serine/threonine kinase, creating antitumor response through maximal RAS/MAPK pathway inhibition. Defactinib is an oral, selective inhibitor of FAK and proline-rich tyrosine kinase (PYK2), the two members of the focal adhesion kinase family of non-receptor protein tyrosine kinases. FAK and PYK2 integrate signals from integrin and growth factor receptors to regulate cell proliferation.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
Verastem Discontinues RAMP 203 Trial, Shifts Focus to VS-7375
- Trial Termination: Verastem Oncology announced the discontinuation of the RAMP 203 trial due to increased competition and higher response benchmarks, halting patient enrollment while allowing current patients to continue treatment at the investigator's discretion, highlighting the challenging market environment.
- Resource Reallocation: The company will redirect resources to VS-7375, an oral KRAS G12D inhibitor that has demonstrated a 69% response rate in 16 patients, indicating its potential in advanced non-small cell lung cancer and other solid tumors.
- Strategic Potential: Management cited stronger strategic potential for VS-7375 in an SEC filing, particularly with ongoing progress in RAMP 205, which evaluates the combination of avutometinib and defactinib with chemotherapy.
- Market Reaction: Following the announcement, Verastem's stock fell 4.34% to $7.75, reflecting investor concerns about the company's future prospects, which may impact its financing and R&D capabilities.
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