Suvretta Capital Reduces Arcutis Stake by $35.78 Million
- Reduction Activity: Suvretta Capital sold nearly 1.1 million shares of Arcutis Biotherapeutics during the quarter ending September 30, reducing its position by $35.78 million, which lowered its stake to approximately 10.48 million shares valued at $197.51 million, reflecting a risk management strategy amid market volatility.
- Holding Proportion Change: This transaction decreased Suvretta's stake in Arcutis to about 5.06%, yet Arcutis remains the fund's largest reported holding, indicating ongoing confidence in its future potential despite the reduction.
- Market Performance: As of November 13, Arcutis shares were priced at $30, marking a staggering 100% increase over the past year, significantly outperforming the S&P 500's 15% rise, which underscores market recognition of its product line and growth prospects.
- Regulatory Progress: Arcutis recently received FDA acceptance for a supplemental NDA for ZORYVE cream for children, with a target action date of June 29, which will aid the company in expanding its presence in the pediatric dermatology market and further solidify its market position.
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- Position Change: On February 5, Tejara Capital reported the complete sale of its 520,503 shares in Arcutis Biotherapeutics for approximately $9.81 million, indicating a significant decrease in the value of its holdings in the company.
- Portfolio Adjustment: This sale reduced Tejara's exposure to Arcutis from 5.1% of AUM last quarter to zero, reflecting a reassessment of risk, likely as a risk management strategy rather than a negative outlook on the business.
- Performance Metrics: As of February 4, Arcutis shares were priced at $26.08, marking a 99.1% increase over the past year, significantly outperforming the S&P 500's 14% gain, underscoring the company's strong fundamentals.
- Future Outlook: Management projects net product sales of approximately $455 million to $470 million for 2026, indicating sustained demand growth, suggesting that Tejara's exit does not undermine the company's long-term growth potential.

- Significant Sales Growth: Since its launch in 2022, Arcutis' ZORYVE product has seen sales reach $59.6 million in 2023 and $166.5 million in 2024, reflecting strong physician adoption and market demand, with 2025 YTD revenue hitting $244.6 million, further solidifying its market position in chronic inflammatory skin disease treatment.
- Substantial Market Potential: Arcutis anticipates net product revenue for ZORYVE to range between $455 million and $470 million in 2026, with peak sales projected to reach $2.6 billion to $3.5 billion, indicating significant growth opportunities in the dermatology market and potential to displace traditional topical corticosteroids.
- Ongoing Clinical Research: The company is conducting safety studies for ZORYVE cream 0.05% in infants aged 3 months to 24 months, with topline data expected this quarter, while also exploring ZORYVE foam 0.3% for vitiligo and hidradenitis suppurativa, expanding its indications.
- Strong Cash Position: As of September 30, 2025, Arcutis reported $191.4 million in cash and cash equivalents, ensuring sufficient funding for future R&D and market expansion, thereby enhancing its viability in the competitive biopharmaceutical landscape.

- ETF Performance Decline: The Sprott Silver Miners & Physical Silver ETF fell approximately 2.3% in Wednesday afternoon trading, reflecting a weak sentiment towards silver mining stocks that could impact investor confidence.
- Individual Stock Weakness: Shares of Americas Gold and Silver dropped about 2.8%, while Vizsla Silver declined by approximately 1.6%, indicating the vulnerability of these companies in the current market environment, potentially leading to capital outflows.
- Market Trend Analysis: The overall decline of the ETF is linked to fluctuations in silver prices and investor risk aversion towards mining stocks, which may influence future investment decisions and capital allocation.
- Investor Focus: As silver mining stocks continue to struggle, investors may need to reassess their allocations within precious metal portfolios to mitigate potential market risks.
- Reduction Activity: Suvretta Capital sold nearly 1.1 million shares of Arcutis Biotherapeutics during the quarter ending September 30, reducing its position by $35.78 million, which lowered its stake to approximately 10.48 million shares valued at $197.51 million, reflecting a risk management strategy amid market volatility.
- Holding Proportion Change: This transaction decreased Suvretta's stake in Arcutis to about 5.06%, yet Arcutis remains the fund's largest reported holding, indicating ongoing confidence in its future potential despite the reduction.
- Market Performance: As of November 13, Arcutis shares were priced at $30, marking a staggering 100% increase over the past year, significantly outperforming the S&P 500's 15% rise, which underscores market recognition of its product line and growth prospects.
- Regulatory Progress: Arcutis recently received FDA acceptance for a supplemental NDA for ZORYVE cream for children, with a target action date of June 29, which will aid the company in expanding its presence in the pediatric dermatology market and further solidify its market position.

- Reduction Dynamics: Suvretta Capital Management sold nearly 1.1 million shares of Arcutis Biotherapeutics (ARQT) in Q3, resulting in a decline of approximately $35.78 million in overall position value, indicating a risk management strategy in response to market volatility.
- Holding Status: As of September 30, Suvretta still holds about 10.48 million shares of ARQT valued at $197.51 million, which constitutes 5.06% of its $3.91 billion 13F reportable assets, confirming that ARQT remains its largest holding.
- Market Performance: As of November 13, ARQT shares were priced at $30, reflecting a staggering 100% increase over the past year, significantly outperforming the S&P 500's 15% rise, showcasing market confidence in its growth potential.
- Strategic Implications: Despite the reduction, Suvretta's strong conviction in ARQT suggests that execution on pediatric expansion and sustained prescription growth will be critical for future success.
Biotech Industry Performance: The biotech sector has shown resilience in 2025, driven by new drug approvals and a surge in mergers and acquisitions, despite challenges from tariffs and geopolitical tensions.
Key Players and Innovations: Companies like Arcutis Biotherapeutics, Amicus Therapeutics, and ANI Pharmaceuticals are highlighted for their strong performance and innovative drug pipelines, particularly in rare diseases and advanced therapies.
Mergers and Acquisitions: The industry is experiencing a wave of consolidation, with major companies acquiring smaller firms to enhance their product portfolios, particularly in oncology, obesity, and gene-editing sectors.
Market Outlook and Challenges: While the demand for innovative treatments remains high, biotech companies face hurdles such as pipeline setbacks, high development costs, and the need for successful commercialization to achieve profitability.







