Setmelanotide: Acquired Hypothalamic Obesity: Launch IMCIVREE in the United States for the treatment of acquired hypothalamic obesity pending FDA approval; the FDA's assigned PDUFA goal date is March 20, 2026; Announce topline data in the 12-patient Japanese cohort of the setmelanotide Phase 3 trial in acquired HO in the first quarter of 2026. Congenital HO: Complete enrollment in the setmelanotide Phase 3 trial substudy in congenital HO in the first half of 2026. Genetically Caused MC4R Pathway Diseases: Announce topline data in the Phase 3 EMANATE trial evaluating setmelanotide in genetically caused MC4R pathway diseases in the first quarter of 2026. Prader-Willi Syndrome: In December 2025, Rhythm announced positive preliminary data for the exploratory phase 2 trial of setmelanotide in patients with PWS that showed BMI and hyperphagia reductions at month 3 and month 6, as well as safety and tolerability consistent with setmelanotide's well-established clinical profile. Rhythm anticipates announcing six-month results from 18 patients from the ongoing Phase 2 trial in the first half of 2026. Bivamelagon: Pending further feedback from U.S. and European regulatory agencies, initiate a pivotal Phase 3 trial evaluating bivamelagon in acquired HO in 2026. RM-718: Complete enrollment in the Phase 1, Part C trial evaluating the weekly, MC4R agonist RM-718 in patients with acquired HO in the first quarter of 2026.
Wall Street analysts forecast RYTM stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for RYTM is 140.62 USD with a low forecast of 123.00 USD and a high forecast of 167.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.
15 Analyst Rating
Wall Street analysts forecast RYTM stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for RYTM is 140.62 USD with a low forecast of 123.00 USD and a high forecast of 167.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.
14 Buy
1 Hold
0 Sell
Strong Buy
Current: 108.360
Low
123.00
Averages
140.62
High
167.00
Current: 108.360
Low
123.00
Averages
140.62
High
167.00
H.C. Wainwright
Buy
maintain
$123 -> $125
2026-01-20
New
Reason
H.C. Wainwright
Price Target
$123 -> $125
AI Analysis
2026-01-20
New
maintain
Buy
Reason
H.C. Wainwright raised the firm's price target on Rhythm Pharmaceuticals to $125 from $123 and keeps a Buy rating on the shares. The company's preliminary Q4 revenue beat estimates, the analyst tells investors in a research note.
Wells Fargo
Derek Archila
Overweight
maintain
$129 -> $145
2026-01-20
New
Reason
Wells Fargo
Derek Archila
Price Target
$129 -> $145
2026-01-20
New
maintain
Overweight
Reason
Wells Fargo analyst Derek Archila raised the firm's price target on Rhythm Pharmaceuticals to $145 from $129 and keeps an Overweight rating on the shares. The firm says IMCIVREE's Q4 revenue beat was a positive surprise. Its IMCIVREE revenue estimates largely remain unchanged for FY26 though it pushes its modest Q1 hypothalamic obesity sales due to the PDUFA extension. However, based on Wells' management dinner, it is now incorporating Prader-Willi syndrome into its model at a 35% probability of success.
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H.C. Wainwright
Raghuram Selvaraju
Buy
upgrade
$110 -> $123
2025-12-22
Reason
H.C. Wainwright
Raghuram Selvaraju
Price Target
$110 -> $123
2025-12-22
upgrade
Buy
Reason
H.C. Wainwright analyst Raghuram Selvaraju raised the firm's price target on Rhythm Pharmaceuticals to $123 from $110 and keeps a Buy rating on the shares. The firm says the company's Prader-Willi syndrome proof-of-concept data demonstrates setmelanotide has a therapeutic impact. It nstituted forward sales forecasts for setmelanotide in PWS in the U.S. only, with a 60% probability of regulatory approval.
Guggenheim
Seamus Fernandez
Buy
maintain
$120 -> $140
2025-12-17
Reason
Guggenheim
Seamus Fernandez
Price Target
$120 -> $140
2025-12-17
maintain
Buy
Reason
Guggenheim analyst Seamus Fernandez raised the firm's price target on Rhythm Pharmaceuticals to $140 from $120 and keeps a Buy rating on the shares. Last week's preliminary Prader-Willi syndrome data for setmelanotide suggests "promising" monotherapy activity in this indication, the analyst tells investors.
About RYTM
Rhythm Pharmaceuticals, Inc. is a commercial-stage biopharmaceutical company. The Company is focused on advancing its melanocortin-4 receptor (MC4R) agonists, including its lead asset, IMCIVREE, as a precision medicine designed to treat hyperphagia and severe obesity caused by rare MC4R pathway diseases. IMCIVREE is approved by the Food and Drug Administration (FDA) for chronic weight management in adult and pediatric patients six years of age and older with monogenic or syndromic obesity due to proopiomelanocortin (POMC), proprotein convertase subtilisin/kexin type 1 (PCSK1) or leptin receptor (LEPR) deficiency as determined by an FDA-approved test demonstrating variants in POMC, PCSK1, or LEPR genes that are interpreted as pathogenic, likely pathogenic, or of uncertain significance (VUS). In addition to setmelanotide, it has two earlier-stage investigational MC4R agonists in clinical development, RM-718, designed for weekly administration, and bivamelagon, an oral small molecule.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
