Relay Therapeutics Shares Surge 60% Over the Past Year as an Investor Acquires Nearly 4 Million Additional Shares
Commodore Capital's Investment: Commodore Capital increased its stake in Relay Therapeutics (NASDAQ: RLAY) by 3.65 million shares in Q3, bringing its total holdings to 17 million shares valued at $88.7 million, which represents 4.3% of its U.S. equity AUM.
Relay Therapeutics Performance: Relay Therapeutics shares have risen 60% over the past year, although they remain nearly 90% below their 2021 highs, highlighting the volatility in early-stage biotech investments.
Company Developments: Relay Therapeutics is focused on developing precision small molecule therapeutics for specific cancers and has made progress in clinical trials while reducing its quarterly net loss and managing expenses effectively.
Market Outlook: The company's improving financial position and ongoing clinical trials are attracting renewed institutional interest, raising questions about its ability to convert pipeline potential into sustainable value for long-term investors.
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Oppenheimer Upgrades Relay Therapeutics Rating
- Rating Upgrade: Oppenheimer has upgraded Relay Therapeutics (RLAY) from 'perform' to 'outperform', anticipating that its lead asset zovegalisib could benefit if Celcuity's (CELC) gedatolisib data underperforms, with a price target of $14 representing an 88% upside from the January 23 close.
- Data Expectations: Analyst Matthew Biegler believes that the data from the gedatolisib VIKTORIA-1 study will underperform expectations and may even fail, creating a 'beatable bar' for zovegalisib, which could positively impact its market performance.
- Therapeutic Advantages: As a mutant-selective inhibitor, zovegalisib may have advantages over gedatolisib in breast cancer treatment, as key opinion leaders indicate a preference for treatment segmentation based on ESR1 and PI3K mutation statuses, providing a strategic edge for Relay Therapeutics' product.
- Market Outlook: Relay Therapeutics is set to showcase its potential at the upcoming Jefferies London Healthcare Conference, and combined with the analyst's optimistic rating, it may attract more investor attention towards its future growth opportunities.

Oncolytics Biotech Secures FDA Approval with 33% Efficacy for New Drug
- Clinical Trial Breakthrough: Oncolytics Biotech's pelareorep achieves a 33% objective response rate in KRAS-mutant metastatic colorectal cancer patients, significantly surpassing the historical benchmark of 6-11%, indicating its potential in cancer treatment.
- Broad Market Outlook: The total addressable market for pelareorep in colorectal cancer is projected to reach $20 billion by 2033, highlighting the drug's significance in addressing unmet medical needs.
- Strategic Planning: The company plans to initiate a controlled study in second-line KRAS-mutant colorectal cancer following consultations with key opinion leaders and regulatory authorities, enhancing the analytical rigor of data to support potential regulatory submissions.
- Expert Endorsement: Dr. Sanjay Goel from Rutgers Cancer Institute emphasizes that a 33% response rate is highly unusual in this setting, underscoring the necessity for further studies and indicating the clinical value of the drug.






