Prelude Therapeutics Unveils JAK2 Inhibitor with IND Filing Expected in Q1 2026
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Dec 06 2025
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Source: Newsfilter
- Disease Modifying Potential: Prelude Therapeutics' first disclosure of the JAK2V617F selective JH2 inhibitor PRT12396 shows robust preclinical activity superior to existing therapies across multiple models, potentially offering new treatment options for MPN patients.
- Clinical Advancement: PRT12396 has completed GLP toxicology studies and is on track for IND filing in Q1 2026, marking a significant milestone in the company's precision oncology efforts.
- Innovative Antibody Drug: The company also presented data on its mCALR-targeted degrader antibody conjugate (DAC), which delivers a CDK9 degrader directly to malignant cells, demonstrating significant disease-modifying potential that could improve patient outcomes.
- Market Outlook: With JAK2V617F mutations affecting approximately 95% of polycythemia vera patients, Prelude's research aims to transform treatment paradigms for MPN patients by selectively targeting mutant cells, enhancing its competitive position in the market.
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About PRLD
Prelude Therapeutics Incorporated is a clinical-stage fully integrated oncology company built on a foundation of drug discovery to deliver novel precision cancer medicines to underserved patients. It has developed a diverse pipeline consisting of multiple distinct programs: kinases, targeted protein degraders, and precision antibody drug conjugates. Its product candidates include PRT3789, PRT2527 and PRT7732. PRT3789 is a highly selective degrader of SMARCA2 protein, which, along with SMARCA4, controls gene regulation through chromatin remodeling. Its CDK9 program is an essential regulator of cancer-promoting transcriptional programs, including those driven by MCL1, MYC and MYB. PRT2527 is designed to be a potent and selective CDK9 inhibitor that has the potential to avoid off-target toxicities observed with other less selective CDK9 inhibitor. PRT7732 is a highly selective and orally bioavailable SMARCA2 degrader.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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