ORIC Pharmaceuticals Reports Enozertinib Phase 1b Trial Data with 67% Preliminary Systemic Activity
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Dec 07 2025
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ORIC Pharmaceuticals announced data from a Phase 1b trial of enozertinib, ORC-114, at the ESMO Asia Congress 2025. Data in treatment-naive and in previously treated NSCLC patients with EGFR exon 20 mutations were presented at an oral session. Key highlights: Highly differentiated 1L preliminary systemic activity of 67% ORR and 100% intracranial ORR , including in patients with active brain metastases; 45% ORR in 2L patients exceeds competitor benchmarks; Competitive safety profile, with no significant off-target toxicity and manageable on-target toxicity, resulting in low discontinuation rate; Enrollment and follow-up continue in 1L patients at selected dose of 80 mg once daily, with next update expected mid-2026 ahead of initiation of potential Phase 3 trial
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Analyst Views on ORIC
Wall Street analysts forecast ORIC stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for ORIC is 19.60 USD with a low forecast of 15.00 USD and a high forecast of 25.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.
12 Analyst Rating
11 Buy
1 Hold
0 Sell
Strong Buy
Current: 10.980
Low
15.00
Averages
19.60
High
25.00
Current: 10.980
Low
15.00
Averages
19.60
High
25.00
About ORIC
ORIC Pharmaceuticals, Inc. is a clinical-stage biopharmaceutical company focused on improving patients’ lives by Overcoming Resistance In Cancer. The Company is advancing a diverse pipeline of clinical and discovery stage therapies designed to counter resistance mechanisms in cancer by leveraging its expertise within three specific areas: hormone-dependent cancers, precision oncology and key tumor dependencies. The Company's clinical-stage product candidates include ORIC-944, an allosteric inhibitor of the polycomb repressive complex 2 (PRC2) via the EED subunit, being developed for prostate cancer, and ORIC-114, a brain penetrant inhibitor that selectively targets EGFR exon 20, HER2 exon 20 and EGFR atypical mutations, being developed across multiple genetically defined cancers. In addition, the Company is also developing multiple discovery stage precision medicines targeting other hallmark cancer resistance mechanisms. Its out-licensing candidates include ORIC-533 and ORIC-613.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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