ORIC Pharmaceuticals Reports 67% ORR in 1L Patients for Enozerinib at ESMO Asia 2025
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Dec 06 2025
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Source: Newsfilter
- Clinical Trial Results: At the ESMO Asia Congress 2025, ORIC Pharmaceuticals announced that the Phase 1b trial of enozertinib achieved a 67% objective response rate (ORR) in first-line patients with EGFR exon 20 mutations, indicating strong efficacy that may surpass competitor benchmarks in treating NSCLC.
- Safety Analysis: Enozerinib demonstrated good tolerability with mostly Grade 1 or 2 treatment-related adverse events (TRAEs) and no significant off-target toxicities, as only three patients discontinued treatment due to TRAEs, highlighting its safety profile in clinical applications.
- Performance in Brain Metastasis Patients: Among patients receiving the 80 mg dose, enozertinib achieved a 100% intracranial ORR and a 93% disease control rate (DCR), underscoring its effectiveness in patients with brain metastases and reinforcing its potential in treating complex cases.
- Future Development Plans: ORIC plans to update data in mid-2026 and advance enozertinib into Phase 3 trials, indicating the company's confidence in the drug and its potential competitiveness in the market.
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Analyst Views on ORIC
Wall Street analysts forecast ORIC stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for ORIC is 19.60 USD with a low forecast of 15.00 USD and a high forecast of 25.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.
12 Analyst Rating
11 Buy
1 Hold
0 Sell
Strong Buy
Current: 10.980
Low
15.00
Averages
19.60
High
25.00
Current: 10.980
Low
15.00
Averages
19.60
High
25.00
About ORIC
ORIC Pharmaceuticals, Inc. is a clinical-stage biopharmaceutical company focused on improving patients’ lives by Overcoming Resistance In Cancer. The Company is advancing a diverse pipeline of clinical and discovery stage therapies designed to counter resistance mechanisms in cancer by leveraging its expertise within three specific areas: hormone-dependent cancers, precision oncology and key tumor dependencies. The Company's clinical-stage product candidates include ORIC-944, an allosteric inhibitor of the polycomb repressive complex 2 (PRC2) via the EED subunit, being developed for prostate cancer, and ORIC-114, a brain penetrant inhibitor that selectively targets EGFR exon 20, HER2 exon 20 and EGFR atypical mutations, being developed across multiple genetically defined cancers. In addition, the Company is also developing multiple discovery stage precision medicines targeting other hallmark cancer resistance mechanisms. Its out-licensing candidates include ORIC-533 and ORIC-613.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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