ORIC Pharmaceuticals Reports 35% ORR in Enozertinib Phase 1b Trial for NSCLC
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Dec 05 2025
0mins
Source: Globenewswire
- Clinical Trial Results: In previously treated NSCLC patients with HER2 exon 20 mutations, enozertinib demonstrated a 35% overall response rate (ORR), with 26% confirmed responses, indicating its potential in treating resistant tumors.
- Patient Enrollment: As of August 29, 2025, 49 patients were dosed, with 47% presenting with brain metastases at baseline, highlighting the drug's applicability in complex cases.
- Safety Analysis: Enozertinib exhibited a manageable safety profile with mostly Grade 1 or 2 treatment-related adverse events, and only 2 patients discontinued treatment due to adverse events, demonstrating its acceptable safety and tolerability.
- Future Development Plans: Based on trial data, ORIC plans to select 80 mg QD as the potential Phase 3 trial dose, continuing enrollment in patients with EGFR mutations, with further updates expected in mid-2026.
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Analyst Views on ORIC
Wall Street analysts forecast ORIC stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for ORIC is 19.60 USD with a low forecast of 15.00 USD and a high forecast of 25.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.
12 Analyst Rating
11 Buy
1 Hold
0 Sell
Strong Buy
Current: 10.980
Low
15.00
Averages
19.60
High
25.00
Current: 10.980
Low
15.00
Averages
19.60
High
25.00
About ORIC
ORIC Pharmaceuticals, Inc. is a clinical-stage biopharmaceutical company focused on improving patients’ lives by Overcoming Resistance In Cancer. The Company is advancing a diverse pipeline of clinical and discovery stage therapies designed to counter resistance mechanisms in cancer by leveraging its expertise within three specific areas: hormone-dependent cancers, precision oncology and key tumor dependencies. The Company's clinical-stage product candidates include ORIC-944, an allosteric inhibitor of the polycomb repressive complex 2 (PRC2) via the EED subunit, being developed for prostate cancer, and ORIC-114, a brain penetrant inhibitor that selectively targets EGFR exon 20, HER2 exon 20 and EGFR atypical mutations, being developed across multiple genetically defined cancers. In addition, the Company is also developing multiple discovery stage precision medicines targeting other hallmark cancer resistance mechanisms. Its out-licensing candidates include ORIC-533 and ORIC-613.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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