NovaBridge Presents Ragistomig Data, Q6W Dosing Enhances Safety Profile
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Dec 10 2025
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Source: Globenewswire
- Clinical Trial Results: Ragistomig's presentation at ESMO-IO 2025 showcased a promising 58.8% disease control rate with the 3mg/kg Q6W dosing schedule, comparable to the 64.3% rate of the Q2W regimen, indicating that the new schedule effectively extends the therapeutic window while maintaining efficacy.
- Safety Improvement: Among 20 patients, only 5% experienced ≥Grade 3 liver function elevation, significantly lower than the 40% observed in the Q2W schedule, highlighting a notable enhancement in safety that supports future combination treatment studies.
- Immunological Data: The new dosing schedule demonstrated positive immunological data with increased CD8+ T cell proliferation and memory T cell activation, reinforcing Ragistomig's potential to provide more effective treatment options for patients with relapsed/refractory solid tumors.
- Strategic Collaboration Outlook: NovaBridge's partnership with ABL Bio will advance Ragistomig into combination studies, aligning with the company's strategy to promote breakthrough therapies globally, which is expected to further enhance its market position in cancer treatment.
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Analyst Views on NBP
Wall Street analysts forecast NBP stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for NBP is 8.00 USD with a low forecast of 7.00 USD and a high forecast of 9.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.
2 Analyst Rating
2 Buy
0 Hold
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Moderate Buy
Current: 3.870
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7.00
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8.00
High
9.00
Current: 3.870
Low
7.00
Averages
8.00
High
9.00
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About NBP
Novabridge Biosciences is a global biotechnology platform company. The Company combines deep business development expertise with agile translational clinical development to identify, accelerate, and advance breakthrough assets. Its differentiated pipeline includes givastomig, a bispecific antibody (Claudin 18.2 x 4-1BB), and VIS-101, a bifunctional biologic, targeting VEGF-A and ANG2. Givastomig conditionally activates T cells via the 4-1BB signaling pathway in the tumor microenvironment where Claudin 18.2 is expressed. Givastomig is being developed to treat Claudin 18.2-positive gastric cancer and other gastrointestinal malignancies. VIS-101 targets VEGF-A and ANG-2 to provide more potent and durable treatment benefits for patients with wet age-related macular degeneration (wet AMD) and diabetic macular edema (DME). VIS-101 is completing a large, randomized, dose-ranging Phase 2 study for wet AMD.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
NovaBridge Biosciences' Chairman Plans to Buy $5 Million in ADSs
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- Diverse Pipeline: The company's pipeline includes potential best-in-class therapies like givastomig and VIS-101, targeting gastric cancer and other malignancies, demonstrating its diversity and innovation in the biopharmaceutical sector.
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