NovaBridge Biosciences Reports 77% Response Rate in HER2-Negative Gastric Cancer Study
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Jan 06 2026
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Source: NASDAQ.COM
- Significant Efficacy: NovaBridge's Phase 1b combination study of givastomig with nivolumab and chemotherapy in HER2-negative metastatic gastric cancer demonstrated an overall response rate of 77% at 8 mg/kg, indicating the potential to transform first-line treatment options.
- Extended Survival: The median progression-free survival reached 16.9 months at the 8 mg/kg dose, with a six-month landmark progression-free survival rate of 73%, providing patients with a longer survival period and enhancing the clinical value of the therapy.
- Good Safety Profile: The combination therapy exhibited a safety profile comparable to current standard-of-care treatments, demonstrating good tolerability, which may position it as a viable option for future therapies and improve patient treatment experiences.
- Stock Price Surge: NovaBridge's shares rose over 11% in pre-market trading after closing at $4.37, up 2.34%, reflecting the market's positive reaction to the study results and potentially attracting more investor interest in its future developments.
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Analyst Views on NBP
Wall Street analysts forecast NBP stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for NBP is 8.00 USD with a low forecast of 7.00 USD and a high forecast of 9.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.
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Moderate Buy
Current: 3.870
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7.00
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9.00
Current: 3.870
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About NBP
Novabridge Biosciences is a global biotechnology platform company. The Company combines deep business development expertise with agile translational clinical development to identify, accelerate, and advance breakthrough assets. Its differentiated pipeline includes givastomig, a bispecific antibody (Claudin 18.2 x 4-1BB), and VIS-101, a bifunctional biologic, targeting VEGF-A and ANG2. Givastomig conditionally activates T cells via the 4-1BB signaling pathway in the tumor microenvironment where Claudin 18.2 is expressed. Givastomig is being developed to treat Claudin 18.2-positive gastric cancer and other gastrointestinal malignancies. VIS-101 targets VEGF-A and ANG-2 to provide more potent and durable treatment benefits for patients with wet age-related macular degeneration (wet AMD) and diabetic macular edema (DME). VIS-101 is completing a large, randomized, dose-ranging Phase 2 study for wet AMD.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
NovaBridge Biosciences' Chairman Plans to Buy $5 Million in ADSs
- Chairman's Purchase Plan: Fu Wei, Executive Chairman of NovaBridge Biosciences, intends to purchase up to $5 million in the company's ADSs through his controlled entity in open market transactions, reflecting confidence in the company's future growth.
- Positive Clinical Data: The recent positive dose expansion data for givastomig from the Phase 1b study reinforces NovaBridge's clinical development capabilities and market potential in treating gastric cancer.
- Global Platform Development: NovaBridge is committed to accelerating access to innovative medicines by combining deep business development expertise with agile clinical development, showcasing the strategic value of its global biotechnology platform.
- Diverse Pipeline: The company's pipeline includes potential best-in-class therapies like givastomig and VIS-101, targeting gastric cancer and other malignancies, demonstrating its diversity and innovation in the biopharmaceutical sector.
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