Molecular Partners Updates 2026 Milestones and Development Plans
Molecular Partners provided an update on its latest progress, developments plans and expected 2026 milestones, which it will present at the 44th Annual J.P. Morgan Healthcare Conference in San Francisco, California. MP0712 & Radio-DARPin pipeline: The Investigational New Drug application has been cleared and a Phase 1/2a trial has now started. A first site is open and dosing of the first patient is expected in Q1 2026. The Phase 1/2a study is a multi-center study in the US, with the objectives to assess safety and determine a recommended phase 2 dose for MP0712. The study contains an imaging and dosimetry step with 203Pb-labeled MP0712. The Company expects initial clinical data from the study in 2026. MP0317: The Company completed a Phase 1 dose escalation study of MP0317 in patients with advanced solid tumors with 46 patients treated across 9 dose levels, and has presented comprehensive biomarker analyses from the trial at SITC 2024 showing tumor-localized CD40 activation and tumor microenvironment remodeling. MP0533: Molecular Partners plans to support the exploration of MP0533 in combination, both in patients with relapsed/refractory disease as well as in front-line, and has been approached by several consortia expressing interest in conducting such studies. The Company is actively engaging with key opinion leaders and regulators to shape the next phase of development, and anticipates updating the clinical plan for MP0533 in H1 2026. Switch-DARPin: Based on the encouraging pre-clinical data presented in 2025 at AACR and SITC, the Company intends to nominate a lead Switch-DARPin candidate for development in H1 2026 and will provide an update on the program at AACR 2026.
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Wall Street Analysts Adjust Ratings on Key Stocks
- Visa Rating Upgrade: Cantor Fitzgerald analyst Ramsey El-Assal initiated coverage on Visa Inc (NYSE:V) with an Overweight rating and a price target of $400, indicating significant upside from Monday's closing price of $328.49, reflecting confidence in its future growth.
- Intuitive Surgical New Rating: TD Cowen analyst Mathew Blackman initiated coverage on Intuitive Surgical Inc (NASDAQ:ISRG) with a Buy rating and a price target of $660, which, compared to its Monday closing price of $528.81, highlights market recognition of its innovative technologies.
- Molecular Partners Buy Rating: HC Wainwright & Co. analyst Robert Burns initiated coverage on Molecular Partners AG (NASDAQ:MOLN) with a Buy rating and a price target of $13, representing significant upside from its Monday closing price of $4.00, indicating optimistic market expectations regarding its R&D progress.
- Mastercard Rating Upgrade: Cantor Fitzgerald analyst Ramsey El-Assal initiated coverage on Mastercard Inc (NYSE:MA) with an Overweight rating and a price target of $650, showing a positive outlook based on its Monday closing price of $527.36, reflecting confidence in its market performance.
Molecular Partners Initiates MP0712 Clinical Trial, First Patient Dosing Expected Q1 2026
- Clinical Trial Launch: Molecular Partners has initiated a Phase 1/2a clinical trial for MP0712 in the US, with first patient dosing expected in Q1 2026, aiming to assess safety and determine the recommended dose, thereby enhancing the company's leadership in targeted radiotherapy.
- Strong Cash Position: As of December 31, 2025, the company reported cash and cash equivalents of CHF 93.1 million, which is projected to fund operating expenses and capital expenditures until 2028, ensuring the company's capacity for R&D and market expansion in the coming years.
- New Drug Development Progress: The Phase 2 trial for MP0317 is now open, targeting 75 patients to evaluate the clinical benefits of its combination with standard care, thereby strengthening the company's competitive position in cholangiocarcinoma treatment.
- Multi-Target Therapy: The Phase 1/2a trial for MP0533 is ongoing, with preliminary data indicating good tolerability and antitumor activity in acute myeloid leukemia patients, with an update on the clinical development path expected in H1 2026, further solidifying the company's product pipeline.
