Ionis' Tryngolza Set to Become First Blockbuster Drug with Peak Revenue Potential of $2 Billion
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Jan 14 2026
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Source: Yahoo Finance
- Drug Approval Outlook: Ionis' Tryngolza has received approval for familial chylomicronemia syndrome and submitted a New Drug Application to the FDA for severe hypertriglyceridemia in 2025, which is expected to significantly enhance its market competitiveness.
- Clinical Trial Results: In the CORE-1 and CORE-2 trials, Tryngolza achieved a 72% significant reduction in triglyceride levels at six months, with an 85% reduction in acute pancreatitis event rates, demonstrating its groundbreaking efficacy in treatment.
- Revenue Forecast Increase: Following its success in severe hypertriglyceridemia, Ionis raised the annual peak revenue forecast for Tryngolza from $1 billion to $2 billion, reflecting a substantial growth in its market potential.
- Future R&D Plans: Ionis anticipates five Phase III trial readouts in 2026, including the GSK-partnered drug bepirovirsen, further strengthening its research capabilities in chronic disease treatment.
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Analyst Views on IONS
Wall Street analysts forecast IONS stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for IONS is 92.67 USD with a low forecast of 65.00 USD and a high forecast of 110.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.
14 Analyst Rating
13 Buy
1 Hold
0 Sell
Strong Buy
Current: 81.920
Low
65.00
Averages
92.67
High
110.00
Current: 81.920
Low
65.00
Averages
92.67
High
110.00
About IONS
Ionis Pharmaceuticals, Inc. develops six marketed medicines for serious diseases, including medicines for neurologic and cardiovascular diseases. Its marketed medicines consist of TRYNGOLZA, WAINUA (eplontersen), SPINRAZA (nusinersen), QALSODY (tofersen), TEGSEDI (inotersen) and WAYLIVRA (volanesorsen). TRYNGOLZA reduces triglyceride levels in adults with familial chylomicronemia syndrome (FCS). WAINUA is approved for the treatment of the polyneuropathy of hereditary transthyretin-medicated amyloidosis (ATTRv-PN) in adults. SPINRAZA is used for the treatment of pediatric and adult patients with spinal muscular atrophy. QALSODY is approved for the treatment of Amyotrophic Lateral Sclerosis in adults who have a mutation in the superoxide dismutase 1 (SOD1) gene, or SOD1-ALS. TEGSEDI is approved for the treatment of ATTRv-PN in adults. WAYLIVRA is approved as an adjunct to diet in adult patients with genetically confirmed FCS and at high risk of acute, potentially fatal pancreatitis.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
Ionis Pharmaceuticals Insider Sold Shares Worth $323,490, According to a Recent SEC Filing
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