ImmunityBio Updates Phase 2 Clinical Results from QUILT 3.078
Written by Emily J. Thompson, Senior Investment Analyst
Updated: 6d ago
0mins
ImmunityBio announced updated Phase 2 clinical results from QUILT 3.078, evaluating a chemotherapy-free combination immunotherapy regimen in patients with second-line recurrent or progressive glioblastoma, as well as patients treated under single-patient INDs across first- to third-line disease. Primary endpoint of QUILT-3.078 is overall survival; median overall survival has not yet been reached, with 19 of 23 enrolled patients alive as of January 22. Fourteen patients have evaluable data, with the longest survival from time of disease recurrence reaching 12 months to date and ongoing. Baseline mean absolute lymphocyte count among these 14 patients was 0.9 x 103/uL, confirming severe lymphopenia at enrollment. ALC increased within one treatment cycle, with mean ALC rising to greater than or equal to 1.4 x 103/uL. Immune competence was maintained, with statistically significant increases from baseline observed at all assessments through 20 weeks with Anktiva + CAR-NK ANKTIVA + CAR-NK demonstrated a manageable safety profile following a total of 219 doses administered to date, with three treatment-related serious adverse events reported among 41 GBM patients enrolled across QUILT-3.078 and single-patient INDs. Randomized controlled trials in both first line and second line glioblastoma are in development.
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Analyst Views on IBRX
Wall Street analysts forecast IBRX stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for IBRX is 7.33 USD with a low forecast of 5.00 USD and a high forecast of 9.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.
3 Analyst Rating
3 Buy
0 Hold
0 Sell
Strong Buy
Current: 6.150
Low
5.00
Averages
7.33
High
9.00
Current: 6.150
Low
5.00
Averages
7.33
High
9.00
About IBRX
Immunitybio, Inc. is a vertically integrated, clinical-stage biotechnology company developing therapies and vaccines that bolster the natural immune system to defeat cancers and infectious diseases. Using its applied science and platforms to treat cancers, including the development of potential cancer vaccines, as well as developing immunotherapies and cell therapies to reduce or eliminate the need for standard high-dose chemotherapy. Its platforms and their associated product candidates are designed to attack cancer and infectious pathogens by activating both the innate immune system, including NK cells, dendritic cells, and macrophages, as well as the adaptive immune system comprising B and T cells, in an orchestrated manner. Its platforms for the development of biologic product candidates include antibody-cytokine fusion proteins, vaccine vectors, and cell therapies. Its biologic commercial product candidate, Anktiva, is an IL-15 superagonist antibody-cytokine fusion protein.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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Continue Reading