Context Therapeutics Showcases CT-95 and CT-202 Initiatives at the 2025 SITC Annual Meeting
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Nov 07 2025
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Source: Newsfilter
Context Therapeutics Overview: Context Therapeutics Inc. is a clinical-stage biopharmaceutical company focused on developing T cell engaging bispecific antibodies for solid tumors, with two key programs, CT-95 and CT-202, presented at the SITC 40th Annual Meeting.
CT-95 Program Details: CT-95 is a bispecific T cell engager targeting mesothelin, currently in a Phase 1 trial with promising safety data, and initial results are expected in mid-2026.
CT-202 Program Insights: CT-202 targets Nectin-4 and shows strong preclinical activity, with plans to initiate a first-in-human trial by the second quarter of 2026 following necessary regulatory filings.
Forward-Looking Statements: The company’s press release includes forward-looking statements regarding future operations and expectations, which involve risks and uncertainties that could affect actual outcomes.
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Analyst Views on CNTX
Wall Street analysts forecast CNTX stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for CNTX is 5.25 USD with a low forecast of 4.00 USD and a high forecast of 7.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.
5 Analyst Rating
5 Buy
0 Hold
0 Sell
Strong Buy
Current: 2.400
Low
4.00
Averages
5.25
High
7.00
Current: 2.400
Low
4.00
Averages
5.25
High
7.00
About CNTX
Context Therapeutics Inc. is a clinical-stage biopharmaceutical company, which is engaged in advancing T cell engaging (TCE) bispecific antibodies (bsAb) for solid tumors. It is building a portfolio of TCE bispecific therapeutics, including CTIM-76, a Claudin 6 (CLDN6) x CD3 TCE, CT-95, a Mesothelin (MSLN) x CD3 TCE, and CT-202, a Nectin cell adhesion protein 4 (Nectin-4) x CD3 TCE. CLDN6 is a tight junction membrane protein target expressed in multiple solid tumors and absent from or expressed at low levels in healthy adult tissues. CT-95 is intended to redirect T-cell-mediated lysis toward malignant cells expressing MSLN. MSLN is a membrane protein overexpressed in approximately 30% of cancers. Nectin-4 is a target for cancer therapy using a traditional antibody-drug conjugate, but it is also associated with certain adverse events, including neuropathy and rash. CT-202 is a pH-dependent TCE that is designed to be preferentially active within the acidic tumor microenvironment.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
Context Therapeutics Grants 120,000 Stock Options to Attract New Employees
- Employee Incentive Program: Context Therapeutics has granted a total of 120,000 non-qualified stock options to two new employees as an inducement for accepting employment, demonstrating the company's proactive strategy in talent acquisition.
- Option Grant Details: The stock options were granted at exercise prices of $1.47 and $1.49 per share, based on the closing prices on the grant dates, reflecting the company's confidence in its stock value.
- Long-Term Incentive Mechanism: The stock options have a 10-year term and vest over four years, with 25% vesting on the first anniversary and the remainder vesting in monthly installments, aimed at enhancing employee commitment and stability.
- Company Strategic Direction: Context Therapeutics focuses on developing T cell engaging bispecific antibodies for solid tumors, aiming to accelerate its innovative drug development process by attracting top talent, thereby enhancing its market competitiveness.
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