Coherus Oncology Showcases Multiomic Biomarker Data for CHS-114, a Selective Anti-CCR8 Cytolytic Antibody, at SITC Conference
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Nov 07 2025
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Source: Newsfilter
CHS-114 Clinical Trial Results: Coherus Oncology's CHS-114, an anti-CCR8 antibody, showed effective depletion of CCR8+ Tregs and increased CD8 T cells in head and neck squamous cell carcinoma (HNSCC) patients, indicating promising immune remodeling and antitumor activity.
Combination Therapy with Toripalimab: The combination of CHS-114 with toripalimab resulted in enhanced immune activation and a significant increase in CD8+ T cell proliferation, supporting further development of this treatment strategy in advanced solid tumors.
Safety Profile and Efficacy: The ongoing Phase 1b trial demonstrated a manageable safety profile for CHS-114, with early signs of antitumor activity, including a partial response in a refractory HNSCC patient.
Future Development Plans: Coherus aims to optimize dosing for CHS-114 in combination with toripalimab, addressing FDA's Project Optimus and advancing to Phase 2 trials based on the promising results from the current study.
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Analyst Views on CHRS
Wall Street analysts forecast CHRS stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for CHRS is 5.50 USD with a low forecast of 4.00 USD and a high forecast of 7.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.
3 Analyst Rating
3 Buy
0 Hold
0 Sell
Strong Buy
Current: 2.215
Low
4.00
Averages
5.50
High
7.00
Current: 2.215
Low
4.00
Averages
5.50
High
7.00
About CHRS
Coherus Oncology, Inc., formerly Coherus BioSciences, Inc., is a fully integrated commercial-stage oncology company with an approved PD-1 inhibitor, LOQTORZI, and a pipeline that includes two mid-stage clinical candidates targeting liver, lung, head & neck, and other cancers. LOQTORZI (toripalimab-tpzi) is its immuno-oncology franchise. LOQTORZI is the FDA-approved treatment indicated in combination with chemotherapy for recurrent or metastatic nasopharyngeal carcinoma (NPC) and is also in development for the treatment of additional tumor types. Its CHS-114 pipeline is a highly selective cytolytic CCR8 antibody that specifically binds and preferentially depletes CCR8+ tumor regulatory T cells (Tregs) with no off-target binding. Its Casdozokitug pipeline is a first-in-class, clinical-stage IL-27 antagonist, with demonstrated monotherapy activity in treatment-refractory NSCLC and clear cell renal cell carcinoma (ccRCC) and combination activity in hepatocellular carcinoma (HCC).
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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