Bright Minds' BMB-101 Shows Significant Seizure Reduction in Phase 2 Trial
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Jan 06 2026
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Source: Globenewswire
- Clinical Trial Results: Bright Minds' BMB-101 demonstrated a 73.1% median reduction in absence seizures among 24 drug-resistant epilepsy patients in the Phase 2 BREAKTHROUGH trial, indicating significant efficacy and a favorable safety profile.
- Patient Background: Among participants, the Absence Seizures cohort had an average of 3 concomitant anti-seizure treatments, while the DEE cohort had 5, with many patients having previously failed up to 16 treatments, highlighting the critical need for BMB-101.
- Safety Analysis: The majority of treatment-emergent adverse events were mild (79.6%), with no serious treatment-related adverse events reported, suggesting strong tolerability that may facilitate future market adoption.
- Next Steps: The company has initiated preparations for global registrational trials in 2026 for Absence Seizures and DEE, indicating a proactive approach to capturing future market opportunities.
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Analyst Views on DRUG
Wall Street analysts forecast DRUG stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for DRUG is 121.00 USD with a low forecast of 80.00 USD and a high forecast of 147.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.
5 Analyst Rating
5 Buy
0 Hold
0 Sell
Strong Buy
Current: 80.240
Low
80.00
Averages
121.00
High
147.00
Current: 80.240
Low
80.00
Averages
121.00
High
147.00
About DRUG
Bright Minds Biosciences Inc. is a biotechnology company, which is engaged in developing treatments for patients with neurological and psychiatric disorders. The Company is focused on developing highly selective 5-HT2 agonists for the treatment of drug-resistant epilepsy, depression, and other central nervous system (CNS) disorders. Its Serotonin (5-HT) is a neurotransmitter in the brain and modulates many biological functions. Dysfunction of serotonin receptors, transporters, and associated neurocircuits is fundamental to many diseases including epilepsies and neuro psychiatric. Its pipeline includes BMB-101, BMB-xxx, BMB-201, and BMB-202. The Company has a portfolio of patented, selective serotonin (5-HT2C, 5-HT2A and 5-HT2C/A-receptor subtypes) agonists that were identified by using high-throughput screening methods in combination with advanced molecular modeling techniques to interrogate the interaction between the drug and its targeted receptors to increase downstream signaling.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
Bright Minds Biosciences Prices 1.945M Shares at $90 for $175.05M Offering
- Offering Size: Bright Minds Biosciences announces the pricing of 1,945,000 common shares at $90 each, anticipating gross proceeds of $175.05 million, which will provide crucial funding for the company's future clinical trials.
- Funding for Trials: The proceeds will be used to finance clinical trials for absence seizures, DEE, and Prader-Willi Syndrome, while also initiating phase 1 clinical trials for BMB-105, thereby advancing the company's drug development pipeline.
- Underwriter Support: Jefferies, TD Cowen, Piper Sandler & Co., and Cantor are acting as joint book-running managers for the offering, ensuring professionalism and efficiency in the fundraising process, which enhances market confidence in the company's future growth.
- Termination of ATM Program: Concurrently with the pricing of this offering, the company announced the termination of its equity distribution agreement, which allowed for up to $100 million in market offerings, indicating a strategic focus on the current fundraising efforts.
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