Analyst Predicts $5 Billion Peak Sales for Evommune's Skin Disorder Treatment, Calling It a 'Blockbuster Commercial Opportunity'
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Dec 01 2025
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Source: Benzinga
Evommune's New Drug Potential: William Blair initiated coverage on Evommune, Inc., emphasizing the promise of its MRGPRX2 inhibitor EVO756 for chronic urticaria, supported by strong early data and a significant market opportunity for an effective oral therapy.
Clinical Trial Results: The Phase 2 data revealed a 30% complete response rate in chronic inducible urticaria after four weeks, with 41% of participants achieving a meaningful reduction in itch scores, and the company is advancing EVO756 into atopic dermatitis with results expected in 2026.
Market Outlook: Analyst Matt Phipps projected peak sales of EVO756 could reach $5 billion, highlighting a strong unmet need for effective oral treatments in chronic spontaneous urticaria, especially as recent drug approvals leave room for alternatives.
Stock Performance: Following the coverage initiation, EVMN stock saw a 2.9% increase, trading at $21.31, reflecting investor interest in the company's potential and the attractiveness of oral autoimmune therapies.
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Analyst Views on EVMN
Wall Street analysts forecast EVMN stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for EVMN is 38.60 USD with a low forecast of 35.00 USD and a high forecast of 42.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.
7 Analyst Rating
7 Buy
0 Hold
0 Sell
Strong Buy
Current: 20.490
Low
35.00
Averages
38.60
High
42.00
Current: 20.490
Low
35.00
Averages
38.60
High
42.00
About EVMN
Evommune, Inc. is a clinical-stage biotechnology company developing therapies that target key drivers of chronic inflammatory diseases. Its initial clinical development programs are focusing on chronic spontaneous urticaria (CSU), atopic dermatitis (AD) and ulcerative colitis (UC). Its product candidates include EVO756 and EVO301. The Company's advanced clinical-stage product candidate, EVO756, is a potent and highly selective oral small molecule antagonist of MRGPRX2, a receptor predominantly found on mast cells and peripheral sensory neurons, which is initially being evaluated in Phase II trials for the treatment of CSU and AD. The Company's second clinical-stage product candidate, EVO301, is a long-acting fusion protein consisting of an IL-18 binding protein (BP) and an anti-serum albumin Fab-associated (SAFA) domain, which is being evaluated in Phase II trials for the treatment of AD and UC.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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