Cogent Biosciences Announces Q3 Net Loss of $80.9 Million, Up from $70.6 Million Last Year
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Nov 03 2025
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Third Quarter Progress: Cogent has had a productive third quarter, preparing to report results from the Phase 3 PEAK trial for bezuclastinib in Gastrointestinal Stromal Tumor patients and the APEX trial in Advanced Systemic Mastocytosis patients.
ASH 2025 Presentations: The company will present three bezuclastinib studies at ASH 2025, including two oral presentations on the SUMMIT trial results for NonAdvanced Systemic Mastocytosis patients.
Research Pipeline Updates: Cogent has shared updated preclinical data showcasing the potential of its pan-KRAS inhibitor and plans to introduce a selective JAK2 V617F mutant inhibitor at ASH 2025, with both programs on track for IND in 2026.
Financial Discipline and NDA Filing: The company emphasizes its financial discipline and business execution as it approaches pivotal data readouts and prepares for its first NDA filing for NonAdvSM later this year.
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Analyst Views on COGT
Wall Street analysts forecast COGT stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for COGT is 48.70 USD with a low forecast of 34.00 USD and a high forecast of 67.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.
11 Analyst Rating
9 Buy
2 Hold
0 Sell
Strong Buy
Current: 38.360
Low
34.00
Averages
48.70
High
67.00
Current: 38.360
Low
34.00
Averages
48.70
High
67.00
About COGT
Cogent Biosciences, Inc. is a biotechnology company. The Company is focused on developing precision therapies for genetically defined diseases. The Company’s clinical program, bezuclastinib, is a selective tyrosine kinase inhibitor that is designed to potently inhibit the KIT D816V mutation as well as other mutations in KIT exon 17. KIT D816V is responsible for driving systemic mastocytosis, a serious disease caused by unchecked proliferation of mast cells. In addition to bezuclastinib, the Company is developing a portfolio of novel targeted therapies to help patients fighting serious, genetically driven diseases initially targeting mutations in FGFR2, ErbB2 and PI3Kα. SUMMIT is its randomized, global, multicenter, double-blind, placebo-controlled, multi-part Phase II clinical trial for patients with Non-AdvSM. APEX is an open-label, global, multicenter study evaluating the safety, efficacy, pharmacokinetic, and pharmacodynamic profiles of bezuclastinib.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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