Acrivon Reports 52% cORR for ACR-368 in Phase 2b Endometrial Cancer Trial
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Jan 08 2026
0mins
Source: NASDAQ.COM
- Clinical Trial Results: Acrivon Therapeutics has unveiled promising Phase 2b data for its lead candidate ACR-368, achieving a confirmed overall response rate of 52% in patients with serous endometrial cancer who have received two or fewer prior treatments, showcasing the drug's potential in precision medicine.
- Biomarker Impact: The response rate climbs to 67% in biomarker-positive patients, not only highlighting ACR-368's effectiveness in targeting specific patient populations but also underscoring its strategic significance in addressing the unmet needs of difficult-to-treat endometrial cancer.
- Global Expansion Plans: To accelerate enrollment and broaden patient access, Acrivon is expanding the trial into the European Union, a strategic move that reflects the company's confidence in advancing treatment options globally and is expected to enhance its market competitiveness.
- Pipeline Development Outlook: Beyond ACR-368, Acrivon is advancing other candidates like ACR-2316, which has shown early signs of tumor shrinkage, and ACR-6840 targeting CDK11, further solidifying the company's position in biomarker-driven oncology innovation.
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Analyst Views on ACRV
Wall Street analysts forecast ACRV stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for ACRV is 10.50 USD with a low forecast of 7.00 USD and a high forecast of 19.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.
6 Analyst Rating
5 Buy
1 Hold
0 Sell
Strong Buy
Current: 1.890
Low
7.00
Averages
10.50
High
19.00
Current: 1.890
Low
7.00
Averages
10.50
High
19.00
About ACRV
Acrivon Therapeutics, Inc. is a clinical-stage biopharmaceutical company developing precision oncology medicines. It uses its precision Generative Phosphoproteomics platform, Acrivon Predictive Precision Proteomics (AP3), to develop its pipeline of oncology drug candidates. Its lead candidate, ACR-368, is a selective small molecule inhibitor which targets CHK1 and CHK2 at sub single-digit nM and single-digit nM potency in intact cells, respectively, in a registrational Phase II trial across multiple solid tumor types. Using its AP3 platform, it has developed a predictive OncoSignature test for ACR-368, called ACR-368 OncoSignature, that can predict patient response to ACR-368 monotherapy and therefore improve the clinical overall response rate (ORR) and has the potential to enable drug development. Its preclinical program, ACR-2316, is advancing in investigational new drug-enabling studies. It is a novel, dual WEE1 and PKMYT1 inhibitor small molecule development candidate.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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