Goldman Sachs Initiates Coverage On Silence Therapeutics with Sell Rating, Announces Price Target of $6

Lombard Odier's Stake Reduction: Lombard Odier Asset Management (USA) Corp sold 3,334,000 shares of Bausch Health Companies, reducing its position by approximately $22.56 million, which now represents 0.74% of the fund's assets.

Bausch Health's Financial Struggles: Bausch Health Companies has faced a decline in share price, down 24.6% over the past year, raising concerns about its ability to manage heavy debt and ongoing legal liabilities.

Investor Sentiment: The reduction in Lombard Odier's stake suggests a shift in investor confidence, indicating that while there may still be potential upside, the fund no longer holds the same level of conviction in Bausch Health's recovery.

Future Outlook: The company's ability to improve its cash generation and manage its capital structure will be crucial for its long-term potential, as it seeks to avoid asset sales that could undermine its equity case.

Biotechnology Sector Performance: Biotechnology shares are down approximately 2.1% on Monday, with notable declines from Emergent BioSolutions and Silence Therapeutics, which fell by 15.4% and 8.1%, respectively.

Market Context: The decline in biotechnology stocks is part of a broader market trend, with auto dealerships also lagging behind on the same day.

Source Disclaimer: The views expressed in the article are those of the author and do not necessarily represent the opinions of Nasdaq, Inc.

Video Content: A video segment highlights the sector laggards, specifically focusing on auto dealerships and biotechnology stocks.

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Divesiran Development: Silence Therapeutics presented promising data on divesiran as a first-in-class siRNA for Polycythemia Vera (PV) at the EHA 2025, showing effective hematocrit control and minimal need for phlebotomies, with Phase 2 trial enrollment expected to complete by year-end 2025.

Financial Overview: The company reported a net loss of $27.4 million for Q2 2025, with cash reserves of approximately $114.2 million projected to fund operations through 2028, while R&D expenses increased due to advancing clinical trials.

Divesiran Phase 1 Study Results: Updated data from the SANRECO Phase 1 study presented at the EHA 2025 Annual Meeting shows that divesiran effectively maintains hematocrit levels in patients with polycythemia vera, significantly reducing the need for phlebotomies while demonstrating a favorable safety profile.

SANRECO Phase 2 Study Progress: Silence Therapeutics announced that the SANRECO Phase 2 study of divesiran has surpassed 50% enrollment and is on track for full enrollment by the end of 2025, indicating strong support from the medical community for this first-in-class siRNA therapy.

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