BriaCell Therapeutics (BCTX) Shares Surge 39% on Positive Clinical Results for Bria-OTS Immunotherapy
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Jan 13 2026
0mins
Should l Buy BCTX?
Source: NASDAQ.COM
- Clinical Trial Success: BriaCell's Bria-OTS personalized immunotherapy achieved complete resolution of lung metastasis in a metastatic breast cancer patient, confirmed at multiple timepoints over 11 months, demonstrating the therapy's potential without treatment-limiting toxicities.
- Strong Stock Reaction: Following the announcement, BCTX shares surged 39.06% to $10.61, reflecting strong investor interest in this clinical milestone, with trading volume significantly increasing as a result.
- Market Volatility: BCTX's 52-week price range of $3.00 to $98.20 illustrates substantial volatility tied to clinical progress and sentiment in the biotech sector, indicating potential risks for investors.
- Increased Investor Confidence: The positive clinical results not only bolster confidence in the Bria-OTS platform but may also attract more investor attention towards BriaCell's future developments, potentially driving further stock price increases.
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Analyst Views on BCTX
About BCTX
BriaCell Therapeutics Corp. is a clinical-stage biotechnology company that develops novel immunotherapies to transform cancer care. Bria-IMT, its Phase 3 lead candidate, is a patented, off-the-shelf, cell-based, targeted immunotherapy that activates the patient’s immune system to specifically kill cancer cells without harming other cells. The Company is advancing its Bria-IMT targeted immunotherapy in combination with an immune check point inhibitor (Retifanlimab) in a pivotal Phase 3 study in metastatic breast cancer. It is also developing personalized off-the-shelf immunotherapies, Bria-OTS and Bria-OTS+, which provides a platform technology to develop personalized off-the-shelf immunotherapies for numerous types of cancer, and a soluble CD80 protein therapeutic which act both as a stimulator of the immune system, as well as an immune checkpoint inhibitor. Its pipeline also includes Bria-IMT + CPI, Bria-BRES/BRES+, Bria-PROS+, Bria-LUNG+ and Bria-MEL+.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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- Significant Clinical Efficacy: The Bria-IMT treatment achieved complete resolution of right temporal lobe metastasis in a 66-year-old female patient, who survived 27 months post-enrollment, demonstrating the therapy's potential in heavily pre-treated patients.
- Evidence of Immune Activation: CD8 ImmunoPET imaging revealed a significant increase in CD8+ T cells in the cervical lymph nodes post-Bria-IMT treatment, indicating immune system activation that may contribute to long-term survival.
- Study Scale and Results: Among 54 heavily pre-treated metastatic breast cancer patients, 37 received the Bria-IMT regimen, with no reported treatment discontinuations related to Bria-IMT to date, indicating good safety and tolerability of the therapy.
- Future Research Prospects: The ongoing Phase 3 clinical trial (NCT06072612) by BriaCell will further validate the efficacy of Bria-IMT, potentially bringing new hope to cancer treatment.
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- Strong Treatment Continuity: No Bria-IMT-related discontinuations have been reported to date, suggesting good tolerability of the regimen among patients, which may provide new treatment options for heavily pre-treated individuals.
- Clinical Trial Progress: The Bria-IMT regimen continues under Fast Track Designation from the US FDA, expected to offer more effective treatment options for late-stage breast cancer patients, addressing the urgent market need for new therapies.
- Future Research Directions: BriaCell's ongoing pivotal Phase 3 study will focus on overall survival as its primary endpoint, aiming to further validate the efficacy of Bria-IMT and promote its broader acceptance in clinical applications.
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- Warrant Information: Each unit consists of one common share and one warrant, the latter allowing purchase of common shares at an exercise price of $6.93, expiring five years post-issuance, enhancing potential returns for investors.
- Stock Price Impact: Following the announcement, BCTX's stock plummeted 54.12% to $5.01, reflecting a highly negative market reaction despite a previous surge to $12.10 due to positive results in treating breast cancer patients.
- Future Trading Arrangements: The warrants have been approved for listing on the Nasdaq Capital Market, expected to begin trading under the symbol
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- Significant Clinical Efficacy: The Bria-IMT treatment achieved complete resolution of right temporal lobe metastasis in a 66-year-old female patient, who survived 27 months post-enrollment, demonstrating the therapy's potential in heavily pre-treated patients.
- Evidence of Immune Activation: CD8 ImmunoPET imaging revealed a significant increase in CD8+ T cells in the cervical lymph nodes post-Bria-IMT treatment, indicating immune system activation that may contribute to long-term survival.
- Study Scale and Results: Among 54 heavily pre-treated metastatic breast cancer patients, 37 received the Bria-IMT regimen, with no reported treatment discontinuations related to Bria-IMT to date, indicating good safety and tolerability of the therapy.
- Future Research Prospects: The ongoing Phase 3 clinical trial (NCT06072612) by BriaCell will further validate the efficacy of Bria-IMT, potentially bringing new hope to cancer treatment.
See More
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- Impressive Survival Data: As of the latest assessment, nine patients treated with Bria-IMT since 2022 have survived over 18 months, significantly exceeding benchmarks for standard therapies, indicating the potential efficacy of this treatment.
- Strong Treatment Continuity: No Bria-IMT-related discontinuations have been reported to date, suggesting good tolerability of the regimen among patients, which may provide new treatment options for heavily pre-treated individuals.
- Clinical Trial Progress: The Bria-IMT regimen continues under Fast Track Designation from the US FDA, expected to offer more effective treatment options for late-stage breast cancer patients, addressing the urgent market need for new therapies.
- Future Research Directions: BriaCell's ongoing pivotal Phase 3 study will focus on overall survival as its primary endpoint, aiming to further validate the efficacy of Bria-IMT and promote its broader acceptance in clinical applications.
See More
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- Retail Sales Surge: U.S. retail sales increased by 0.6% month-over-month in November, marking the largest surge since July, indicating a potential rebound in consumer spending that could positively impact economic recovery.
- Tech Stock Decline: Information technology stocks fell by 1.3% on Wednesday, reflecting market concerns over the tech sector, which may affect investor confidence and lead to capital outflows.
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See More
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- Revenue Growth: The bank's revenue net of interest expense increased by 7% year-over-year to $28.532 billion, exceeding the analyst consensus estimate of $27.944 billion, reflecting strong performance and effective cost management in a competitive landscape.
- Market Dynamics: While U.S. stocks traded lower overall, with the Nasdaq Composite falling over 100 points, energy stocks rose by 0.9%, indicating a divergence in market performance that may present investors with opportunities to reassess their portfolios.
- Economic Indicators: U.S. retail sales increased by 0.6% month-over-month in November, marking the largest surge since July, suggesting a rebound in consumer spending that could positively impact future economic growth.
See More
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- Glaukos Sales Projection: Glaukos Corp anticipates FY25 sales of $507 million, yet its shares fell 12.1% in pre-market trading, indicating market concerns about its growth outlook despite the positive sales forecast.
- Briacell's Sharp Decline: Briacell Therapeutics' announcement of a $30 million public offering led to a staggering 53.1% drop in its stock price during pre-market trading, reflecting investor apprehension regarding the financing strategy.
- Trip.com Investigation Impact: Trip.com Group confirmed it is under investigation by China's SAMR for potential anti-monopoly violations, resulting in a 9.3% decline in its pre-market stock price, which may adversely affect its market performance and investor confidence.
- Pearson Trading Update: Pearson PLC's trading update for 2025 caused its shares to drop 7.2% in pre-market trading, indicating a cautious market sentiment regarding its future performance.
See More
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- Public Offering Details: BriaCell Therapeutics announced a public offering of 5.367 million units priced at $5.59 each, aiming for gross proceeds of approximately $30 million, which will fund working capital and general corporate purposes.
- Warrant Information: Each unit consists of one common share and one warrant, the latter allowing purchase of common shares at an exercise price of $6.93, expiring five years post-issuance, enhancing potential returns for investors.
- Stock Price Impact: Following the announcement, BCTX's stock plummeted 54.12% to $5.01, reflecting a highly negative market reaction despite a previous surge to $12.10 due to positive results in treating breast cancer patients.
- Future Trading Arrangements: The warrants have been approved for listing on the Nasdaq Capital Market, expected to begin trading under the symbol
See More
