Adial Pharmaceuticals Welcomes U.S. Senate Backing for Broader Clinical Trial Endpoints in Alcohol and Substance Use Disorder Treatments
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Aug 20 2025
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Should l Buy ADIL?
Source: Newsfilter
Legislative Support for Clinical Trials: The U.S. Senate has shown support for expanding clinical trial endpoints beyond abstinence in substance use disorder treatments, particularly for Alcohol Use Disorder (AUD), encouraging the FDA to consider measures like reduced cravings.
Adial Pharmaceuticals' Response: Adial Pharmaceuticals applauds this legislative move as it aligns with their patient-centric approach and supports the development of their lead drug candidate, AD04, aimed at reducing alcohol intake and cravings.
AD04's Development and Potential: AD04 is a serotonin-3 receptor antagonist currently in Phase 3 trials, showing promise in reducing drinking among patients with AUD and potentially applicable to other addictive disorders such as opioid use disorder and gambling.
Forward-Looking Statements and Risks: The company acknowledges that its future success depends on various factors including regulatory approvals, funding, and market acceptance, while also emphasizing the need for ongoing updates regarding their progress and risks involved.
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Analyst Views on ADIL
Wall Street analysts forecast ADIL stock price to fall
1 Analyst Rating
1 Buy
0 Hold
0 Sell
Moderate Buy
Current: 2.850
Low
1.50
Averages
1.50
High
1.50
Current: 2.850
Low
1.50
Averages
1.50
High
1.50
About ADIL
Adial Pharmaceuticals, Inc. is a clinical-stage biopharmaceutical company. The Company is focused on the development of therapies for the treatment and prevention of addiction and related disorders. The Company’s lead investigational new drug product, AD04, is a genetically targeted, serotonin-3 receptor antagonist, therapeutic agent for the treatment of Alcohol Use Disorder (AUD) in heavy drinking patients and was recently investigated in the Company’s ONWARD pivotal Phase III clinical trial for the potential treatment of AUD in subjects with certain target genotypes identified using the Company’s proprietary companion diagnostic genetic test. AD04 is also used for the treatment of other addictive disorders, such as Opioid Use Disorder, obesity, smoking, and other drug addictions. The Company’s wholly owned subsidiary is Purnovate, Inc.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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- Sector Dynamics: Consumer staples stocks gained 0.3%, while consumer discretionary stocks fell by 2.2%, reflecting a divergence in market confidence across different consumer sectors, which could impact short-term performance of related companies.
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- Precision Medicine Strategy: Adial's investigational therapy AD04 is designed to treat Alcohol Use Disorder (AUD) using a precision medicine approach, aligning with the new legislation's focus on non-abstinence recovery goals, potentially accelerating clinical trial timelines and broadening clinical relevance.
- Public Health Challenge: AUD remains a significant public health issue affecting millions, and the passage of the new bill may provide Adial with clearer regulatory frameworks to address this substantial unmet treatment need.
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See More
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See More
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- FDA Regulatory Discussions: Adial has completed End-of-Phase-2 discussions with the FDA, receiving input on the Phase 3 adaptive trial design and broader clinical program, covering key elements such as patient population and endpoints, ensuring focus on biomarker-positive and negative groups.
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