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PALI Overview

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$
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0.000(0.000%)Aft-market
ET
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0.000
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ET
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Intellectia

Loading chart...

High
2.000
Open
1.940
VWAP
1.98
Vol
3.53M
Mkt Cap
331.77M
Low
1.925
Amount
6.96M
EV/EBITDA(TTM)
--
Total Shares
165.88M
EV
198.46M
EV/OCF(TTM)
--
P/S(TTM)
--
Palisade Bio, Inc. is a clinical-stage biopharmaceutical company. The Company is focused on developing and advancing therapeutics for patients living with autoimmune, inflammatory, and fibrotic diseases. The Company’s lead product candidate, PALI-2108, is being developed as a treatment for patients living with inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Fibrostenotic Crohn’s disease (FSCD). The Company is conducting a Phase I human clinical trial of its lead product candidate, PALI-2108, for the treatment of UC. In UC mouse models, the Company has demonstrated the dose-dependent efficacy of PALI-2108. It utilizes dextran sodium sulfate (DSS)-induced UC mouse models and targets engagement in oxazolone-induced colitis. PALI-2108 targets the key phosphodiesterase-4 (PDE4) in colon tissues and prevents it from breaking down cyclic Adenosine Monophosphate (cAMP) molecules which regulate inflammation in the body.
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Events Timeline

(ET)
2026-02-23
08:50:00
Palisade Bio Presents New Data for PALI-2108 at ECCO Congress
select
2026-02-17 (ET)
2026-02-17
09:10:00
Palisade Bio Appoints Bram Verstockt to Clinical Advisory Board
select
2026-01-29 (ET)
2026-01-29
08:50:00
Palisade Bio Appoints Two IBD Experts to Advisory Board
select
2026-01-07 (ET)
2026-01-07
08:31:00
Palisade Bio Secures $500,000 Investment from Crohn's & Colitis Foundation
select
2025-12-30 (ET)
2025-12-30
08:50:00
Palisade Bio Secures Japan Patent for PALI-2108
select
2025-12-29 (ET)
2025-12-29
16:40:00
Major Averages Finish Broadly Lower as S&P 500 and Dow Hit Record Highs
select

News

Benzinga
6.0
02-25Benzinga
Wall Street Analysts Adjust Ratings
  • Analyst Rating Changes: Top Wall Street analysts have adjusted their ratings on several stocks, including upgrades, downgrades, and initiations, reflecting varying market perspectives that could influence investor decisions.
  • Market Dynamics Overview: While specific stock names are not mentioned, such rating changes typically have a direct impact on the stock prices of the affected companies, prompting investors to closely monitor these shifts to optimize their portfolios.
  • Investor Focus: For those considering buying ALMS stock, analysts' opinions will serve as a crucial reference point, potentially affecting their buying decisions and overall market sentiment.
  • Data Source Note: This information is provided by Benzinga, highlighting the significance of analyst ratings in investment decisions while reminding investors to approach market analyses and recommendations with caution.
Newsfilter
8.5
02-09Newsfilter
Palisade Bio to Participate in Immunology Symposium
  • Virtual Fireside Chat: Palisade Bio will participate in the Piper Sandler Virtual Immunology Symposium on February 12, 2026, from 1:30 PM to 1:55 PM ET, featuring CEO JD Finley and CMO Dr. Mitchell Jones discussing the company's innovations in immunology.
  • PALI-2108 Drug Development: PALI-2108 is a once-daily oral PDE4 inhibitor prodrug designed for targeted activation in the terminal ileum and colon, aimed at improving pharmacology and tolerability for patients with inflammatory and fibrotic diseases.
  • Clinical Trial Results: In a recent Phase 1b trial, PALI-2108 achieved a 100% clinical response in ulcerative colitis patients with no serious adverse events, demonstrating favorable tolerability and pharmacokinetics consistent with localized activation.
  • Future Research Plans: The company is advancing towards a Phase 2 clinical study for PALI-2108, designed to evaluate clinical remission, response, and pharmacodynamic biomarkers over 12 weeks, with an extension phase to assess maintenance of remission.
Globenewswire
8.5
01-16Globenewswire
Palisade Bio's PALI-2108 Clinical Data Selected for Two International IBD Meetings
  • Clinical Data Presentation: Palisade Bio's PALI-2108 has been selected for poster presentations at two international inflammatory bowel disease meetings in January and February 2026, showcasing the drug's potential in ulcerative colitis treatment and enhancing the company's reputation in the biopharmaceutical sector.
  • Immune Balance Restoration: PALI-2108 rapidly restores immune-epithelial balance in ulcerative colitis patients through gut-targeted PDE4B inhibition, indicating its clinical efficacy and potentially providing new treatment options for patients.
  • Successful Clinical Trials: In a recent Phase 1b trial, PALI-2108 achieved a 100% clinical response in ulcerative colitis patients with no serious adverse events, demonstrating favorable tolerability and pharmacokinetics, which strengthens its market competitiveness.
  • Future Research Plans: Palisade Bio plans to initiate a Phase 2 clinical study for PALI-2108 in 2026 to evaluate clinical remission and pharmacodynamic biomarkers in ulcerative colitis, further validating its therapeutic effects and expanding its indications.
Globenewswire
7.5
01-07Globenewswire
Palisade Bio Secures $500K Investment to Advance PALI-2108
  • Strategic Investment: The Crohn’s & Colitis Foundation has approved a strategic equity investment of up to $500,000 in Palisade Bio through its IBD Ventures program, aimed at supporting the clinical and mechanistic development of PALI-2108, reflecting strong endorsement of the drug's potential.
  • Clinical Progress: PALI-2108 achieved a 100% clinical response in the UC cohort with no serious adverse events, indicating favorable tolerability and pharmacokinetics in treating moderate to severe ulcerative colitis and fibrostenotic Crohn’s disease.
  • R&D Plans: Palisade Bio is preparing to submit a Phase 2 Investigational New Drug application to the FDA in 2026 for PALI-2108, further advancing its clinical development to meet the urgent need for non-immunosuppressive therapies for patients.
  • Market Potential: The targeted delivery design of PALI-2108 aims to minimize systemic side effects while maximizing anti-inflammatory and anti-fibrotic effects, which is expected to significantly enhance treatment options for IBD patients and strengthen the company's competitive position in the biopharmaceutical sector.
Benzinga
2.0
01-05Benzinga
Momentus Inc. Shares Surge 57% Following Fuel Tank Development Announcement
  • Stock Surge: Momentus Inc. shares soared 57% to $8.98 following the announcement of an additive-manufactured fuel tank, indicating strong market confidence in its aerospace service potential.
  • Flight Testing Plans: The fuel tank is scheduled for flight testing aboard the Vigoride-7 orbital service vehicle, which not only enhances the company's technological capabilities but also opens new revenue streams for future commercial launches.
  • FDA Clearance: GH Research PLC shares rose 17% to $15.43 after the FDA lifted the clinical hold on its Investigational New Drug Application, marking a significant breakthrough in the company's development process that could accelerate product commercialization.
  • Market Volatility: Despite a generally positive market, Zenas Biopharma Inc. shares plummeted 57% due to results from the INDIGO trial, reflecting the high-risk nature of the biopharmaceutical sector, necessitating cautious investment evaluations.
Globenewswire
3.5
2025-12-30Globenewswire
Palisade Bio Secures Japanese Patent for PALI-2108, Phase 2 Trials Planned for 2026
  • Patent Protection: Palisade Bio has secured a Japanese patent for PALI-2108, which extends until 2041, ensuring a unique competitive advantage in the Japanese market to meet the urgent needs of ulcerative colitis and Crohn's disease patients.
  • Clinical Progress: PALI-2108 demonstrated a 100% clinical response rate in Phase 1 trials with no serious adverse events, laying a solid foundation for the upcoming Phase 2 IND submission planned for the first half of 2026.
  • Market Potential: Japan represents one of the largest markets for inflammatory bowel disease globally, and the patent acquisition will enhance Palisade Bio's strategic position in this market, expected to significantly boost product acceptance and sales potential.
  • Innovative Drug Development: PALI-2108 is designed for local delivery to minimize systemic side effects, which is anticipated to provide safer treatment options for patients, thereby driving the company's long-term growth in chronic inflammatory and fibrotic diseases.
Wall Street analysts forecast PALI stock price to rise
4 Analyst Rating
Wall Street analysts forecast PALI stock price to rise
4 Buy
0 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
7.00
Averages
13.00
High
25.00
Current: 0.000
sliders
Low
7.00
Averages
13.00
High
25.00
H.C. Wainwright
Buy
initiated
$7
AI Analysis
2026-03-26
New
Reason
H.C. Wainwright
Price Target
$7
AI Analysis
2026-03-26
New
initiated
Buy
Reason
H.C. Wainwright initiated coverage of Palisade Bio with a Buy rating and $7 price target. The firm thinks investors are looking at PALI-2108 "through the lens of older-generation, systemic PDE4 inhibitor programs, rather than the differentiating features of Palisade's drug." The firm says the data and design suggest PALI-2108 may be better and safer in ulcerative colitis.
Stifel
NULL -> Buy
initiated
$5
2026-02-24
Reason
Stifel
Price Target
$5
2026-02-24
initiated
NULL -> Buy
Reason
Stifel initiated coverage of Palisade Bio with a Buy rating and $5 price target. The firm, which views inflammatory bowel disease as a large, validated commercial market where clinical efficacy has largely been stagnant since the approval of Entyvio more than a decade ago, sees Palisade as "well-positioned within this landscape" with PALI-2108, the analyst tells investors.
Unlock Full Analyst Thesis, Get the complete breakdown of rating reason for PALI
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Valuation Metrics

The current forward P/E ratio for Palisade Bio Inc (PALI.O) is -10.99, compared to its 5-year average forward P/E of -1.38. For a more detailed relative valuation and DCF analysis to assess Palisade Bio Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-1.38
Current PE
-10.99
Overvalued PE
0.50
Undervalued PE
-3.25

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
0.00
Current EV/EBITDA
0.00
Overvalued EV/EBITDA
0.00
Undervalued EV/EBITDA
0.00

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
8.47
Current PS
0.00
Overvalued PS
30.32
Undervalued PS
-13.37

Financials

AI Analysis
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Quarterly

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Whales Holding PALI

C
Commodore Capital LP
Holding
PALI
+12.63%
3M Return
V
Vivo Capital, LLC
Holding
PALI
+7.46%
3M Return
P
Perceptive Advisors LLC
Holding
PALI
-0.06%
3M Return
R
RA Capital Management, L.P.
Holding
PALI
-7.24%
3M Return
E
Eversept Partners, L.P.
Holding
PALI
-8.53%
3M Return

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Frequently Asked Questions

What is Palisade Bio Inc (PALI) stock price today?

The current price of PALI is 2 USD — it has increased 2.04

What is Palisade Bio Inc (PALI)'s business?

Palisade Bio, Inc. is a clinical-stage biopharmaceutical company. The Company is focused on developing and advancing therapeutics for patients living with autoimmune, inflammatory, and fibrotic diseases. The Company’s lead product candidate, PALI-2108, is being developed as a treatment for patients living with inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Fibrostenotic Crohn’s disease (FSCD). The Company is conducting a Phase I human clinical trial of its lead product candidate, PALI-2108, for the treatment of UC. In UC mouse models, the Company has demonstrated the dose-dependent efficacy of PALI-2108. It utilizes dextran sodium sulfate (DSS)-induced UC mouse models and targets engagement in oxazolone-induced colitis. PALI-2108 targets the key phosphodiesterase-4 (PDE4) in colon tissues and prevents it from breaking down cyclic Adenosine Monophosphate (cAMP) molecules which regulate inflammation in the body.

What is the price predicton of PALI Stock?

Wall Street analysts forecast PALI stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for PALI is13.00 USD with a low forecast of 7.00 USD and a high forecast of 25.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Palisade Bio Inc (PALI)'s revenue for the last quarter?

Palisade Bio Inc revenue for the last quarter amounts to 0.00 USD, decreased

What is Palisade Bio Inc (PALI)'s earnings per share (EPS) for the last quarter?

Palisade Bio Inc. EPS for the last quarter amounts to -0.16 USD, decreased -89.68

How many employees does Palisade Bio Inc (PALI). have?

Palisade Bio Inc (PALI) has 14 emplpoyees as of March 30 2026.

What is Palisade Bio Inc (PALI) market cap?

Today PALI has the market capitalization of 331.77M USD.