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PALI Overview

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$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
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Intellectia

Loading chart...

High
2.450
Open
2.350
VWAP
2.38
Vol
3.54M
Mkt Cap
402.29M
Low
2.275
Amount
8.40M
EV/EBITDA(TTM)
--
Total Shares
167.62M
EV
256.78M
EV/OCF(TTM)
--
P/S(TTM)
--
Palisade Bio, Inc. is a clinical-stage biopharmaceutical company. The Company is focused on developing and advancing therapeutics for patients living with autoimmune, inflammatory, and fibrotic diseases. The Company’s lead product candidate, PALI-2108, is being developed as a treatment for patients living with inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Fibrostenotic Crohn’s disease (FSCD). The Company is conducting a Phase I human clinical trial of its lead product candidate, PALI-2108, for the treatment of UC. In UC mouse models, the Company has demonstrated the dose-dependent efficacy of PALI-2108. It utilizes dextran sodium sulfate (DSS)-induced UC mouse models and targets engagement in oxazolone-induced colitis. PALI-2108 targets the key phosphodiesterase-4 (PDE4) in colon tissues and prevents it from breaking down cyclic Adenosine Monophosphate (cAMP) molecules which regulate inflammation in the body.
Show More

Events Timeline

(ET)
2026-03-30
16:20:00
Palisade Bio Announces PALI-2108 Clinical Data
select
2026-02-23 (ET)
2026-02-23
08:50:00
Palisade Bio Presents New Data for PALI-2108 at ECCO Congress
select
2026-02-17 (ET)
2026-02-17
09:10:00
Palisade Bio Appoints Bram Verstockt to Clinical Advisory Board
select
2026-01-29 (ET)
2026-01-29
08:50:00
Palisade Bio Appoints Two IBD Experts to Advisory Board
select
2026-01-07 (ET)
2026-01-07
08:31:00
Palisade Bio Secures $500,000 Investment from Crohn's & Colitis Foundation
select

News

Newsfilter
1.0
04-08Newsfilter
Palisade Bio Schedules Virtual Presentation at Needham Healthcare Conference
  • Virtual Presentation Scheduled: Palisade Bio will present virtually at the Needham & Co. 25th Annual Healthcare Conference on April 16, 2026, from 2:15 PM to 2:55 PM ET, showcasing its innovative drug development in inflammatory and fibrotic diseases.
  • Management Engagement: CEO JD Finley and CMO Dr. Mitchell Jones will participate in the conference, engaging in one-on-one meetings with registered investors post-presentation, enhancing transparency and interaction with the investment community.
  • Product Development Progress: The company's lead program, PALI-2108, is a once-daily oral PDE4 inhibitor prodrug designed for selective bioactivation in the ileum and colon, enabling targeted inhibition at disease sites while improving patient convenience and tolerability.
  • Clinical Study Plans: Palisade is advancing towards a Phase 2 clinical study in ulcerative colitis, aimed at evaluating clinical remission, response, and pharmacodynamic biomarkers over 12 weeks, with an extension phase to assess maintenance of remission, highlighting its potential in chronic disease treatment.
seekingalpha
9.0
03-31seekingalpha
Palisade Bio Reports Early Trial Data for PALI-2108 in Crohn’s Disease
  • Clinical Trial Progress: Palisade Bio reported two weeks of data from its early-stage trial of PALI-2108 for fibrostenotic Crohn’s disease, indicating endoscopic response rates comparable to AbbVie's Skyrizi and Rinvoq, highlighting its therapeutic potential.
  • Safety Profile: The therapy showed no serious adverse events among five patients, and the experimental treatment was well tolerated, demonstrating its safety for clinical application.
  • Follow-up Research Plans: Palisade Bio intends to launch a Phase 2 study to further evaluate PALI-2108's efficacy in moderate to severe Crohn’s disease patients, reflecting the company's confidence in the drug's future market potential.
  • Market Outlook: Palisade Bio is viewed as an undervalued biotech firm with blockbuster drug development potential, leading to optimistic market sentiment regarding its future performance.
Benzinga
6.0
02-25Benzinga
Wall Street Analysts Adjust Ratings
  • Analyst Rating Changes: Top Wall Street analysts have adjusted their ratings on several stocks, including upgrades, downgrades, and initiations, reflecting varying market perspectives that could influence investor decisions.
  • Market Dynamics Overview: While specific stock names are not mentioned, such rating changes typically have a direct impact on the stock prices of the affected companies, prompting investors to closely monitor these shifts to optimize their portfolios.
  • Investor Focus: For those considering buying ALMS stock, analysts' opinions will serve as a crucial reference point, potentially affecting their buying decisions and overall market sentiment.
  • Data Source Note: This information is provided by Benzinga, highlighting the significance of analyst ratings in investment decisions while reminding investors to approach market analyses and recommendations with caution.
Newsfilter
8.5
02-09Newsfilter
Palisade Bio to Participate in Immunology Symposium
  • Virtual Fireside Chat: Palisade Bio will participate in the Piper Sandler Virtual Immunology Symposium on February 12, 2026, from 1:30 PM to 1:55 PM ET, featuring CEO JD Finley and CMO Dr. Mitchell Jones discussing the company's innovations in immunology.
  • PALI-2108 Drug Development: PALI-2108 is a once-daily oral PDE4 inhibitor prodrug designed for targeted activation in the terminal ileum and colon, aimed at improving pharmacology and tolerability for patients with inflammatory and fibrotic diseases.
  • Clinical Trial Results: In a recent Phase 1b trial, PALI-2108 achieved a 100% clinical response in ulcerative colitis patients with no serious adverse events, demonstrating favorable tolerability and pharmacokinetics consistent with localized activation.
  • Future Research Plans: The company is advancing towards a Phase 2 clinical study for PALI-2108, designed to evaluate clinical remission, response, and pharmacodynamic biomarkers over 12 weeks, with an extension phase to assess maintenance of remission.
Globenewswire
8.5
01-16Globenewswire
Palisade Bio's PALI-2108 Clinical Data Selected for Two International IBD Meetings
  • Clinical Data Presentation: Palisade Bio's PALI-2108 has been selected for poster presentations at two international inflammatory bowel disease meetings in January and February 2026, showcasing the drug's potential in ulcerative colitis treatment and enhancing the company's reputation in the biopharmaceutical sector.
  • Immune Balance Restoration: PALI-2108 rapidly restores immune-epithelial balance in ulcerative colitis patients through gut-targeted PDE4B inhibition, indicating its clinical efficacy and potentially providing new treatment options for patients.
  • Successful Clinical Trials: In a recent Phase 1b trial, PALI-2108 achieved a 100% clinical response in ulcerative colitis patients with no serious adverse events, demonstrating favorable tolerability and pharmacokinetics, which strengthens its market competitiveness.
  • Future Research Plans: Palisade Bio plans to initiate a Phase 2 clinical study for PALI-2108 in 2026 to evaluate clinical remission and pharmacodynamic biomarkers in ulcerative colitis, further validating its therapeutic effects and expanding its indications.
Globenewswire
7.5
01-07Globenewswire
Palisade Bio Secures $500K Investment to Advance PALI-2108
  • Strategic Investment: The Crohn’s & Colitis Foundation has approved a strategic equity investment of up to $500,000 in Palisade Bio through its IBD Ventures program, aimed at supporting the clinical and mechanistic development of PALI-2108, reflecting strong endorsement of the drug's potential.
  • Clinical Progress: PALI-2108 achieved a 100% clinical response in the UC cohort with no serious adverse events, indicating favorable tolerability and pharmacokinetics in treating moderate to severe ulcerative colitis and fibrostenotic Crohn’s disease.
  • R&D Plans: Palisade Bio is preparing to submit a Phase 2 Investigational New Drug application to the FDA in 2026 for PALI-2108, further advancing its clinical development to meet the urgent need for non-immunosuppressive therapies for patients.
  • Market Potential: The targeted delivery design of PALI-2108 aims to minimize systemic side effects while maximizing anti-inflammatory and anti-fibrotic effects, which is expected to significantly enhance treatment options for IBD patients and strengthen the company's competitive position in the biopharmaceutical sector.
Wall Street analysts forecast PALI stock price to rise
4 Analyst Rating
Wall Street analysts forecast PALI stock price to rise
4 Buy
0 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
7.00
Averages
13.00
High
25.00
Current: 0.000
sliders
Low
7.00
Averages
13.00
High
25.00
Wolfe Research
Andy Chen
Outperform
initiated
$7
AI Analysis
2026-04-08
Reason
Wolfe Research
Andy Chen
Price Target
$7
AI Analysis
2026-04-08
initiated
Outperform
Reason
Wolfe Research analyst Andy Chen initiated coverage of Palisade Bio with an Outperform rating and $7 price target. The firm sees a "quiet 2026," but is bullish into ulcerative colitis data due in the second half of 2027 with the mechanism and the firm's analyses supporting a favorable outcome despite mixed drug class data in the same indication, the analyst tells investors.
Clear Street
Buy
maintain
$12
2026-03-31
Reason
Clear Street
Price Target
$12
2026-03-31
maintain
Buy
Reason
Clear Street keeps a Buy rating and $12 price target on Palisade Bio, saying the decline in the stock price after the Phase 1B Clinical Study of PALI-2108 in Fibrostenotic Crohn's Disease looks misaligned with fundamentals. Together with previously disclosed UC data, the findings provide compelling validation and a strong foundation for PALI-2108's success, and the stock price decline is more timing-driven than data-driven, the analyst tells investors in a research note.
Unlock Full Analyst Thesis, Get the complete breakdown of rating reason for PALI
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Valuation Metrics

The current forward P/E ratio for Palisade Bio Inc (PALI.O) is 0.00, compared to its 5-year average forward P/E of -1.37. For a more detailed relative valuation and DCF analysis to assess Palisade Bio Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-1.37
Current PE
0.00
Overvalued PE
0.48
Undervalued PE
-3.22

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
0.00
Current EV/EBITDA
0.00
Overvalued EV/EBITDA
0.00
Undervalued EV/EBITDA
0.00

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
8.48
Current PS
0.00
Overvalued PS
30.33
Undervalued PS
-13.37

Financials

AI Analysis
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Whales Holding PALI

C
Commodore Capital LP
Holding
PALI
+32.74%
3M Return
V
Vivo Capital, LLC
Holding
PALI
+19.07%
3M Return
P
Perceptive Advisors LLC
Holding
PALI
+15.99%
3M Return
R
RA Capital Management, L.P.
Holding
PALI
+7.21%
3M Return
E
Eversept Partners, L.P.
Holding
PALI
+2.78%
3M Return

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Frequently Asked Questions

What is Palisade Bio Inc (PALI) stock price today?

The current price of PALI is 2.4 USD — it has increased 3

What is Palisade Bio Inc (PALI)'s business?

Palisade Bio, Inc. is a clinical-stage biopharmaceutical company. The Company is focused on developing and advancing therapeutics for patients living with autoimmune, inflammatory, and fibrotic diseases. The Company’s lead product candidate, PALI-2108, is being developed as a treatment for patients living with inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Fibrostenotic Crohn’s disease (FSCD). The Company is conducting a Phase I human clinical trial of its lead product candidate, PALI-2108, for the treatment of UC. In UC mouse models, the Company has demonstrated the dose-dependent efficacy of PALI-2108. It utilizes dextran sodium sulfate (DSS)-induced UC mouse models and targets engagement in oxazolone-induced colitis. PALI-2108 targets the key phosphodiesterase-4 (PDE4) in colon tissues and prevents it from breaking down cyclic Adenosine Monophosphate (cAMP) molecules which regulate inflammation in the body.

What is the price predicton of PALI Stock?

Wall Street analysts forecast PALI stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for PALI is13.00 USD with a low forecast of 7.00 USD and a high forecast of 25.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Palisade Bio Inc (PALI)'s revenue for the last quarter?

Palisade Bio Inc revenue for the last quarter amounts to 0.00 USD, decreased

What is Palisade Bio Inc (PALI)'s earnings per share (EPS) for the last quarter?

Palisade Bio Inc. EPS for the last quarter amounts to -0.16 USD, decreased -89.68

How many employees does Palisade Bio Inc (PALI). have?

Palisade Bio Inc (PALI) has 14 emplpoyees as of April 20 2026.

What is Palisade Bio Inc (PALI) market cap?

Today PALI has the market capitalization of 402.29M USD.