The earnings call reveals several negative factors: declining revenue guidance, margin compression, and a net loss in Q4 2025. Despite growth in biosimilars and cost savings, these are overshadowed by underperformance in key areas like women's health and respiratory portfolio. Additionally, management's vague responses in the Q&A section, especially regarding the Audit Committee investigation, add uncertainty. The slight positive from biosimilars and cost savings isn't enough to outweigh these negatives, leading to an overall negative sentiment, likely resulting in a -2% to -8% stock price decline.