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DNLI Overview

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ET
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Intellectia

Loading chart...

High
19.720
Open
19.440
VWAP
19.55
Vol
352.46K
Mkt Cap
3.11B
Low
19.260
Amount
6.89M
EV/EBITDA(TTM)
--
Total Shares
158.59M
EV
2.25B
EV/OCF(TTM)
--
P/S(TTM)
--
Denali Therapeutics Inc. is a biopharmaceutical company. The Company is focused on developing a broad portfolio of product candidates engineered to cross the blood-brain barrier (BBB) for the treatment of neurodegenerative diseases and lysosomal storage diseases. It has developed a technology, called the TransportVehicle (TV), to address the BBB challenge. Its advanced TV-enabled program is tividenofusp alfa (DNL310, ETV:IDS) for the potential treatment of mucopolysaccharidosis II (MPS II or Hunter syndrome). Its TV-enabled clinical development portfolio also includes DNL126 (ETV:SGSH) for MPS IIIA (Sanfilippo syndrome) and DNL593 (PTV:PGRN) for frontotemporal dementia-granulin (FTD-GRN). Its small-molecule clinical development portfolio includes BIIB122/DNL151 (small molecule LRRK2 inhibitor) for Parkinson’s disease; and DNL343 (small molecule eIF2B activator) for amyotrophic lateral sclerosis (ALS). It is also exploring programs in oncology, inflammation, and other diseases.
Show More

Events Timeline

(ET)
2026-04-05
21:20:00
Denali Therapeutics Regains Full Control of DNL593
select

News

NASDAQ.COM
8.5
04-06NASDAQ.COM
Denali Regains Full Rights to DNL593 Therapy
  • Strategic Restructuring: Denali Therapeutics has regained full rights to DNL593 after Takeda terminated their co-development agreement for strategic reasons, enabling Denali to independently advance the therapy's development.
  • Clinical Progress: DNL593 targets GRN-related Frontotemporal Dementia, with Phase 1/2 trials expected to complete enrollment of 40 patients by the end of 2026; preliminary data shows a dose-dependent increase in cerebrospinal fluid progranulin, indicating robust brain delivery.
  • Technological Advantage: Denali's TransportVehicle platform is described as the first FDA-approved technology for crossing the blood-brain barrier, significantly enhancing brain exposure for large molecules, with preclinical models showing 10-30x higher exposure for antibodies and enzymes, and over 1,000x for oligonucleotides.
  • Future Milestones: With Takeda stepping aside, Denali now fully controls DNL593's intellectual property and development path, with the next major milestone being the patient data readout at the end of 2026, including biomarker results that could validate the FTD-GRN strategy.
Newsfilter
9.0
04-03Newsfilter
Denali Continues Clinical Development of DNL593 After Takeda Collaboration Termination
  • Collaboration Termination: Denali Therapeutics announced the termination of its collaboration agreement with Takeda, a decision unrelated to efficacy or safety, allowing Denali to regain full control of DNL593, thereby enhancing its market position in treating frontotemporal dementia.
  • Clinical Trial Progress: The Phase 1/2 clinical trial for DNL593 has completed enrollment of 40 FTD-GRN patients, with results expected by the end of 2026, which will provide critical data for further development and potentially drive its application in neurodegenerative diseases.
  • Platform Advantage: Denali's TransportVehicle™ technology, which has received FDA approval, effectively crosses the blood-brain barrier, significantly increasing brain exposure for large therapeutic molecules, which is expected to enhance the therapeutic efficacy of DNL593, particularly in the underserved frontotemporal dementia market.
  • Market Potential: Frontotemporal dementia is the most common form of dementia in individuals under 60, and with an aging population, the demand for effective treatments is increasing, positioning Denali's technology platform and product portfolio to capture significant opportunities in this rapidly growing market.
moomoo
7.5
04-03moomoo
Takeda Ends Collaboration Agreement with Denali Therapeutics on DNL593
  • Collaboration Agreement: Denali Therapeutics has entered into a collaboration agreement with DNL593, focusing on the development of therapeutic solutions.

  • Research Focus: The partnership aims to advance research and development in the field of neuroscience, leveraging Denali's expertise and resources.

Newsfilter
8.5
04-01Newsfilter
Avaí Bio Initiates Master Cell Bank Manufacturing
  • Market Potential: The regenerative medicine market is projected to reach $578 billion by 2033, with cell therapy alone surpassing $8.2 billion this year, indicating significant growth potential that attracts investor interest.
  • Manufacturing Challenge Solution: Avaí Bio has initiated the manufacturing of a Master Cell Bank for genetically modified cells overexpressing α-Klotho in collaboration with Austrianova, aiming to address the production bottlenecks in cell therapy and lay the groundwork for future commercialization.
  • Innovative Delivery Mechanism: Austrianova's Cell-in-a-Box® technology protects therapeutic cells within a biocompatible shell, allowing continuous secretion of α-Klotho, which eliminates the manufacturing and logistical burdens of patient-specific autologous therapies, transforming it into a scalable product.
  • Dual-Program Strategy: Avaí Bio's dual-program approach targets both the Klothonova α-Klotho anti-aging platform and the Insulinova diabetes program, expected to tap into multi-billion dollar markets, showcasing the company's strategic positioning in the regenerative medicine sector.
PRnewswire
8.5
04-01PRnewswire
Avaí Bio Initiates Master Cell Bank Manufacturing
  • Market Potential: The regenerative medicine market is projected to reach $578 billion by 2033, with cell therapy alone surpassing $8.2 billion this year, indicating strong growth potential that attracts investor interest.
  • Manufacturing Challenges: The primary bottleneck for cell therapy companies is how to manufacture living therapeutics reliably and affordably at scale, and those who solve this issue will dominate the market.
  • Innovative Technology: Avaí Bio has initiated the manufacturing of a Master Cell Bank of genetically modified cells overexpressing the α-Klotho protein in collaboration with Austrianova, utilizing Cell-in-a-Box® technology to ensure continuous secretion of the protein without immune rejection.
  • Broad Market Demand: α-Klotho is linked to various diseases such as Alzheimer's, cardiovascular disease, and kidney disease, presenting significant market opportunities, and Avaí Bio's dual-program approach aims to effectively address treatment needs in these areas.
NASDAQ.COM
8.5
03-27NASDAQ.COM
Biotech Landscape Update: Regulatory Approvals and Mergers
  • Anavex Drug Withdrawal: Anavex Life Sciences Corp. (AVXL) withdrew its EU marketing application for Alzheimer's drug Blarcamesine after the EMA's CHMP indicated it could not issue a positive opinion, marking a significant setback for the company's lead candidate despite continued support from patient groups.
  • Quoin FDA Alignment: Quoin Pharmaceuticals Ltd. (QNRX) received positive feedback from the FDA confirming that a single Phase 3 trial may suffice for U.S. approval of QRX003 for Netherton Syndrome, with plans to initiate Phase 3 in 2026 and potentially file an NDA in 2027.
  • Corcept Drug Approval: Corcept Therapeutics Inc. (CORT) secured FDA approval for Lifyorli combined with nab-paclitaxel to treat platinum-resistant ovarian cancer, based on Phase 3 ROSELLA trial results involving 381 patients, marking the first FDA-approved selective glucocorticoid receptor antagonist.
  • Merck Acquires Terns: Merck (MRK) announced a definitive agreement to acquire Terns Pharmaceuticals for $53.00 per share, totaling approximately $6.7 billion, which is expected to enhance Merck's presence in hematology, with the transaction anticipated to close in Q2 2026.
Wall Street analysts forecast DNLI stock price to rise
10 Analyst Rating
Wall Street analysts forecast DNLI stock price to rise
10 Buy
0 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
25.00
Averages
32.78
High
40.00
Current: 0.000
sliders
Low
25.00
Averages
32.78
High
40.00
Baird
Outperform
maintain
$32 -> $34
AI Analysis
2026-04-07
New
Reason
Baird
Price Target
$32 -> $34
AI Analysis
2026-04-07
New
maintain
Outperform
Reason
Baird raised the firm's price target on Denali Therapeutics to $34 from $32 and keeps an Outperform rating on the shares. The firm updated its model following the return of DNL-593 from Takeda Pharmaceuticals giving them full control of the FTD-GRN program.
BTIG
Buy
maintain
$38 -> $39
2026-04-06
New
Reason
BTIG
Price Target
$38 -> $39
2026-04-06
New
maintain
Buy
Reason
BTIG raised the firm's price target on Denali Therapeutics to $39 from $38 and keeps a Buy rating on the shares as the company regains full rights to investigational therapy DNL593 for GRN-related Frontotemporal Dementia. Noting a "promising" program is back, the firm says it is "curious as prior failure very modestly related," but notes some caution seems appropriate. With that said, BTIG believes the bigger total addressable market supports raising the price target despite the added risk.
Unlock Full Analyst Thesis, Get the complete breakdown of rating reason for DNLI
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Valuation Metrics

The current forward P/E ratio for Denali Therapeutics Inc (DNLI.O) is 0.00, compared to its 5-year average forward P/E of -12.02. For a more detailed relative valuation and DCF analysis to assess Denali Therapeutics Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-12.02
Current PE
0.00
Overvalued PE
-3.64
Undervalued PE
-20.40

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-9.05
Current EV/EBITDA
0.00
Overvalued EV/EBITDA
-1.53
Undervalued EV/EBITDA
-16.58

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
5Y Average PS
68.93
Current PS
25.81
Overvalued PS
118.52
Undervalued PS
19.33

Financials

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Whales Holding DNLI

A
Artal Group S.A.
Holding
DNLI
+15.49%
3M Return
C
Crestline Investors Inc.
Holding
DNLI
+13.01%
3M Return
B
Bluebox Asset Management Uk Ltd.
Holding
DNLI
+2.36%
3M Return
C
Cercano Management LLC
Holding
DNLI
-0.61%
3M Return
B
Baker Bros. Advisors LP
Holding
DNLI
-2.03%
3M Return

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Frequently Asked Questions

What is Denali Therapeutics Inc (DNLI) stock price today?

The current price of DNLI is 19.67 USD — it has increased 0.25

What is Denali Therapeutics Inc (DNLI)'s business?

Denali Therapeutics Inc. is a biopharmaceutical company. The Company is focused on developing a broad portfolio of product candidates engineered to cross the blood-brain barrier (BBB) for the treatment of neurodegenerative diseases and lysosomal storage diseases. It has developed a technology, called the TransportVehicle (TV), to address the BBB challenge. Its advanced TV-enabled program is tividenofusp alfa (DNL310, ETV:IDS) for the potential treatment of mucopolysaccharidosis II (MPS II or Hunter syndrome). Its TV-enabled clinical development portfolio also includes DNL126 (ETV:SGSH) for MPS IIIA (Sanfilippo syndrome) and DNL593 (PTV:PGRN) for frontotemporal dementia-granulin (FTD-GRN). Its small-molecule clinical development portfolio includes BIIB122/DNL151 (small molecule LRRK2 inhibitor) for Parkinson’s disease; and DNL343 (small molecule eIF2B activator) for amyotrophic lateral sclerosis (ALS). It is also exploring programs in oncology, inflammation, and other diseases.

What is the price predicton of DNLI Stock?

Wall Street analysts forecast DNLI stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for DNLI is32.78 USD with a low forecast of 25.00 USD and a high forecast of 40.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Denali Therapeutics Inc (DNLI)'s revenue for the last quarter?

Denali Therapeutics Inc revenue for the last quarter amounts to 0.00 USD, decreased

What is Denali Therapeutics Inc (DNLI)'s earnings per share (EPS) for the last quarter?

Denali Therapeutics Inc. EPS for the last quarter amounts to -0.73 USD, increased 8.96

How many employees does Denali Therapeutics Inc (DNLI). have?

Denali Therapeutics Inc (DNLI) has 503 emplpoyees as of April 09 2026.

What is Denali Therapeutics Inc (DNLI) market cap?

Today DNLI has the market capitalization of 3.11B USD.