DNLI Stock: Price, Forecast, Financials & AI Analysis

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High

21.710

Open

20.610

VWAP

20.83

Vol

2.48M

Mkt Cap

3.27B

Low

20.157

Amount

51.73M

EV/EBITDA(TTM)

Total Shares

158.71M

2.32B

EV/OCF(TTM)

P/S(TTM)

Denali Therapeutics Inc. is a biopharmaceutical company establishing a new class of biotherapeutics designed to cross the blood-brain barrier using its TransportVehicle platform. It is focused on building a portfolio of therapeutic candidates by investing in its TV franchises, i.e., Enzyme TV (ETV), Oligonucleotide TV (OTV), and Antibody TV (ATV), to advance programs for rare diseases, such as lysosomal storage diseases, and common diseases, such as Alzheimer's disease and Parkinson's disease. Its most advanced TV-enabled program is tividenofusp alfa (DNL310, ETV:IDS) for the potential treatment of mucopolysaccharidosis II (Hunter syndrome). TV-enabled clinical development portfolio also includes DNL126 (ETV:SGSH) for mucopolysaccharidosis IIIA (Sanfilippo syndrome type A), DNL593 (PTV:PGRN) for frontotemporal dementia-granulin, DNL628 (OTV:MAPT) for Alzheimer’s disease, and DNL952 (ETV:GAA) for Pompe disease. It is also pursuing opportunities in other disease areas including oncology.

Events Timeline

(ET)

2026-05-21

18:10:00

Biogen and Denali Discontinue BIIB122 Development

News

4.5

05-22NASDAQ.COM

US Stocks Close Higher as Market Sentiment Improves

4.5

05-22NASDAQ.COM

US Stocks Rise, Nasdaq Hits Weekly High

4.5

05-22NASDAQ.COM

US Stocks Rise as Market Optimism Grows

9.0

05-22seekingalpha

Biogen and Denali Halt Development of Parkinson's Drug BIIB122

9.0

05-22NASDAQ.COM

Biogen and Denali Halt Development of Parkinson's Drug BIIB122

9.0

05-21stocktwits

Biogen and Denali Halt Parkinson's Drug Development

10 Analyst Rating

Wall Street analysts forecast DNLI stock price to rise

10 Buy

0 Hold

0 Sell

Strong Buy

Current: 0.000

Low

25.00

Averages

32.78

High

40.00

Current: 0.000

Low

25.00

Averages

32.78

High

40.00

Morgan Stanley

Sean Laaman

Overweight

downgrade

$42 -> $40

AI Analysis

2026-05-14

Reason

Morgan Stanley

Sean Laaman

Price Target

$42 -> $40

AI Analysis

2026-05-14

downgrade

Overweight

Reason

Morgan Stanley analyst Sean Laaman lowered the firm's price target on Denali Therapeutics to $40 from $42 and keeps an Overweight rating on the shares.

Wedbush

Laura Chico

Outperform

downgrade

$25 -> $23

2026-05-08

Reason

Wedbush

Laura Chico

Price Target

$25 -> $23

2026-05-08

downgrade

Outperform

Reason

Wedbush analyst Laura Chico lowered the firm's price target on Denali Therapeutics to $23 from $25 and keeps an Outperform rating on the shares. The firm notes the Avlayah launch is now underway with initial patients receiving treatment. There is no change to Wedbush's below consensus revenue estimates as the initial quarters lay the groundwork.

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Valuation Metrics

The current forward P/E ratio for Denali Therapeutics Inc (DNLI.O) is 0.00, compared to its 5-year average forward P/E of -11.21. For a more detailed relative valuation and DCF analysis to assess Denali Therapeutics Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.

N/A

5Y Average PE

-11.21

Current PE

0.00

Overvalued PE

-3.83

Undervalued PE

-18.59

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.

N/A

5Y Average EV/EBITDA

-8.42

Current EV/EBITDA

0.00

Overvalued EV/EBITDA

-1.54

Undervalued EV/EBITDA

-15.30

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.

5Y Average PS

67.81

Current PS

29.15

Overvalued PS

117.96

Undervalued PS

17.67

Financials

AI Analysis

Annual

Quarterly

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Frequently Asked Questions

What is Denali Therapeutics Inc (DNLI) stock price today?

The current price of DNLI is 20.61 USD — it has decreased -0.87

What is Denali Therapeutics Inc (DNLI)'s business?

What is the price predicton of DNLI Stock?

Wall Street analysts forecast DNLI stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for DNLI is32.78 USD with a low forecast of 25.00 USD and a high forecast of 40.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Denali Therapeutics Inc (DNLI)'s revenue for the last quarter?

Denali Therapeutics Inc revenue for the last quarter amounts to 0.00 USD, decreased

What is Denali Therapeutics Inc (DNLI)'s earnings per share (EPS) for the last quarter?

Denali Therapeutics Inc. EPS for the last quarter amounts to -0.69 USD, decreased -11.54

How many employees does Denali Therapeutics Inc (DNLI). have?

Denali Therapeutics Inc (DNLI) has 503 emplpoyees as of June 11 2026.

What is Denali Therapeutics Inc (DNLI) market cap?

Today DNLI has the market capitalization of 3.27B USD.

DNLI Overview

DNLI Overview

Events Timeline

News

Valuation Metrics

Forward PE

Forward EV/EBITDA

Forward PS

Financials

Related Community Screener

Whales Holding DNLI

Trading Trends

People Also Watch

Frequently Asked Questions

What is Denali Therapeutics Inc (DNLI) stock price today?

What is Denali Therapeutics Inc (DNLI)'s business?

What is the price predicton of DNLI Stock?

What is Denali Therapeutics Inc (DNLI)'s revenue for the last quarter?

What is Denali Therapeutics Inc (DNLI)'s earnings per share (EPS) for the last quarter?

How many employees does Denali Therapeutics Inc (DNLI). have?

What is Denali Therapeutics Inc (DNLI) market cap?