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DNLI Overview

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ET
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ET
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Intellectia

Loading chart...

High
20.170
Open
19.600
VWAP
19.00
Vol
3.00M
Mkt Cap
2.95B
Low
18.230
Amount
57.00M
EV/EBITDA(TTM)
--
Total Shares
158.68M
EV
2.32B
EV/OCF(TTM)
--
P/S(TTM)
--
Denali Therapeutics Inc. is a biopharmaceutical company establishing a new class of biotherapeutics designed to cross the blood-brain barrier using its TransportVehicle platform. It is focused on building a portfolio of therapeutic candidates by investing in its TV franchises, i.e., Enzyme TV (ETV), Oligonucleotide TV (OTV), and Antibody TV (ATV), to advance programs for rare diseases, such as lysosomal storage diseases, and common diseases, such as Alzheimer's disease and Parkinson's disease. Its most advanced TV-enabled program is tividenofusp alfa (DNL310, ETV:IDS) for the potential treatment of mucopolysaccharidosis II (Hunter syndrome). TV-enabled clinical development portfolio also includes DNL126 (ETV:SGSH) for mucopolysaccharidosis IIIA (Sanfilippo syndrome type A), DNL593 (PTV:PGRN) for frontotemporal dementia-granulin, DNL628 (OTV:MAPT) for Alzheimer’s disease, and DNL952 (ETV:GAA) for Pompe disease. It is also pursuing opportunities in other disease areas including oncology.
Show More

Events Timeline

(ET)
2026-04-05
21:20:00
Denali Therapeutics Regains Full Control of DNL593
select

News

Globenewswire
8.5
04-20Globenewswire
Transformation of Value in Biotechnology Sector
  • Value Shift: The biotechnology sector is undergoing a profound transformation where scientific progress is increasingly viewed as a measurable financial asset rather than just research expenditure, reinforced by fair-value accounting under U.S. GAAP that allows companies to reflect clinical advancements and commercialization timing on their balance sheets.
  • Investment Opportunities in Clinical Assets: Institutional investors are increasingly recognizing the investment value of clinical-stage biotech assets, even in the absence of current revenue, as Oncotelic Therapeutics exemplifies how scientific progress can directly influence financial positioning, significantly enhancing enterprise valuation through its diversified pipeline and 45% stake in GMP Bio.
  • Clinical Development Drives Valuation: As drug candidates advance through clinical development, their value significantly increases due to rising probabilities of success and proximity to commercialization, particularly for late-stage assets nearing regulatory approval, which tend to command a disproportionate share of enterprise value, reflecting investors' focus on pipeline asset maturity.
  • AI and Manufacturing Convergence: AI-driven drug development and GMP-compliant manufacturing platforms are accelerating timelines and improving scalability across the biotech industry, with Oncotelic Therapeutics demonstrating how to integrate oncology drug development with AI platforms, thereby linking scientific advancement with financial valuation and positioning the company favorably in the rapidly evolving biotech landscape.
Newsfilter
8.5
04-20Newsfilter
Biotechnology Sector Undergoes Value Transformation
  • Value Transformation Trend: The biotechnology sector is undergoing a profound transformation where scientific progress is increasingly viewed as a measurable financial asset, particularly as drug candidates approach commercialization, significantly enhancing companies' balance sheet values.
  • Fair Value Accounting Implementation: The adoption of fair-value accounting under U.S. GAAP allows life sciences companies to incorporate clinical progress, probability of success, and commercialization timing into financial reporting, thereby increasing transparency and attracting institutional investors to clinical-stage biotech assets.
  • Clinical Progress Drives Valuation: As drug candidates advance through clinical development, their value increases significantly due to rising probabilities of success and proximity to commercialization, with late-stage assets commanding a disproportionate share of enterprise value, reflecting investors' focus on pipeline asset maturity.
  • AI and GMP Manufacturing Convergence: The integration of AI-driven drug development and GMP-compliant manufacturing accelerates timelines and enhances scalability across the biotech industry, improving clinical development efficiency and market readiness, further driving the alignment of scientific progress with financial valuation.
NASDAQ.COM
8.5
04-06NASDAQ.COM
Denali Regains Full Rights to DNL593 Therapy
  • Strategic Restructuring: Denali Therapeutics has regained full rights to DNL593 after Takeda terminated their co-development agreement for strategic reasons, enabling Denali to independently advance the therapy's development.
  • Clinical Progress: DNL593 targets GRN-related Frontotemporal Dementia, with Phase 1/2 trials expected to complete enrollment of 40 patients by the end of 2026; preliminary data shows a dose-dependent increase in cerebrospinal fluid progranulin, indicating robust brain delivery.
  • Technological Advantage: Denali's TransportVehicle platform is described as the first FDA-approved technology for crossing the blood-brain barrier, significantly enhancing brain exposure for large molecules, with preclinical models showing 10-30x higher exposure for antibodies and enzymes, and over 1,000x for oligonucleotides.
  • Future Milestones: With Takeda stepping aside, Denali now fully controls DNL593's intellectual property and development path, with the next major milestone being the patient data readout at the end of 2026, including biomarker results that could validate the FTD-GRN strategy.
Newsfilter
9.0
04-03Newsfilter
Denali Continues Clinical Development of DNL593 After Takeda Collaboration Termination
  • Collaboration Termination: Denali Therapeutics announced the termination of its collaboration agreement with Takeda, a decision unrelated to efficacy or safety, allowing Denali to regain full control of DNL593, thereby enhancing its market position in treating frontotemporal dementia.
  • Clinical Trial Progress: The Phase 1/2 clinical trial for DNL593 has completed enrollment of 40 FTD-GRN patients, with results expected by the end of 2026, which will provide critical data for further development and potentially drive its application in neurodegenerative diseases.
  • Platform Advantage: Denali's TransportVehicle™ technology, which has received FDA approval, effectively crosses the blood-brain barrier, significantly increasing brain exposure for large therapeutic molecules, which is expected to enhance the therapeutic efficacy of DNL593, particularly in the underserved frontotemporal dementia market.
  • Market Potential: Frontotemporal dementia is the most common form of dementia in individuals under 60, and with an aging population, the demand for effective treatments is increasing, positioning Denali's technology platform and product portfolio to capture significant opportunities in this rapidly growing market.
moomoo
7.5
04-03moomoo
Takeda Ends Collaboration Agreement with Denali Therapeutics on DNL593
  • Collaboration Agreement: Denali Therapeutics has entered into a collaboration agreement with DNL593, focusing on the development of therapeutic solutions.

  • Research Focus: The partnership aims to advance research and development in the field of neuroscience, leveraging Denali's expertise and resources.

Newsfilter
8.5
04-01Newsfilter
Avaí Bio Initiates Master Cell Bank Manufacturing
  • Market Potential: The regenerative medicine market is projected to reach $578 billion by 2033, with cell therapy alone surpassing $8.2 billion this year, indicating significant growth potential that attracts investor interest.
  • Manufacturing Challenge Solution: Avaí Bio has initiated the manufacturing of a Master Cell Bank for genetically modified cells overexpressing α-Klotho in collaboration with Austrianova, aiming to address the production bottlenecks in cell therapy and lay the groundwork for future commercialization.
  • Innovative Delivery Mechanism: Austrianova's Cell-in-a-Box® technology protects therapeutic cells within a biocompatible shell, allowing continuous secretion of α-Klotho, which eliminates the manufacturing and logistical burdens of patient-specific autologous therapies, transforming it into a scalable product.
  • Dual-Program Strategy: Avaí Bio's dual-program approach targets both the Klothonova α-Klotho anti-aging platform and the Insulinova diabetes program, expected to tap into multi-billion dollar markets, showcasing the company's strategic positioning in the regenerative medicine sector.
Wall Street analysts forecast DNLI stock price to rise
10 Analyst Rating
Wall Street analysts forecast DNLI stock price to rise
10 Buy
0 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
25.00
Averages
32.78
High
40.00
Current: 0.000
sliders
Low
25.00
Averages
32.78
High
40.00
Baird
Outperform
maintain
$32 -> $34
AI Analysis
2026-04-07
Reason
Baird
Price Target
$32 -> $34
AI Analysis
2026-04-07
maintain
Outperform
Reason
Baird raised the firm's price target on Denali Therapeutics to $34 from $32 and keeps an Outperform rating on the shares. The firm updated its model following the return of DNL-593 from Takeda Pharmaceuticals giving them full control of the FTD-GRN program.
BTIG
Buy
maintain
$38 -> $39
2026-04-06
Reason
BTIG
Price Target
$38 -> $39
2026-04-06
maintain
Buy
Reason
BTIG raised the firm's price target on Denali Therapeutics to $39 from $38 and keeps a Buy rating on the shares as the company regains full rights to investigational therapy DNL593 for GRN-related Frontotemporal Dementia. Noting a "promising" program is back, the firm says it is "curious as prior failure very modestly related," but notes some caution seems appropriate. With that said, BTIG believes the bigger total addressable market supports raising the price target despite the added risk.
Unlock Full Analyst Thesis, Get the complete breakdown of rating reason for DNLI
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Valuation Metrics

The current forward P/E ratio for Denali Therapeutics Inc (DNLI.O) is 0.00, compared to its 5-year average forward P/E of -11.78. For a more detailed relative valuation and DCF analysis to assess Denali Therapeutics Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-11.78
Current PE
0.00
Overvalued PE
-3.64
Undervalued PE
-19.92

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-8.87
Current EV/EBITDA
0.00
Overvalued EV/EBITDA
-1.49
Undervalued EV/EBITDA
-16.25

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
5Y Average PS
68.65
Current PS
28.93
Overvalued PS
118.44
Undervalued PS
18.87

Financials

AI Analysis
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Whales Holding DNLI

A
Artal Group S.A.
Holding
DNLI
+15.00%
3M Return
B
Bluebox Asset Management Uk Ltd.
Holding
DNLI
+11.02%
3M Return
C
Crestline Investors Inc.
Holding
DNLI
+9.30%
3M Return
C
Cercano Management LLC
Holding
DNLI
+7.83%
3M Return
B
Baker Bros. Advisors LP
Holding
DNLI
+4.86%
3M Return

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Frequently Asked Questions

What is Denali Therapeutics Inc (DNLI) stock price today?

The current price of DNLI is 18.6 USD — it has decreased -7.28

What is Denali Therapeutics Inc (DNLI)'s business?

Denali Therapeutics Inc. is a biopharmaceutical company establishing a new class of biotherapeutics designed to cross the blood-brain barrier using its TransportVehicle platform. It is focused on building a portfolio of therapeutic candidates by investing in its TV franchises, i.e., Enzyme TV (ETV), Oligonucleotide TV (OTV), and Antibody TV (ATV), to advance programs for rare diseases, such as lysosomal storage diseases, and common diseases, such as Alzheimer's disease and Parkinson's disease. Its most advanced TV-enabled program is tividenofusp alfa (DNL310, ETV:IDS) for the potential treatment of mucopolysaccharidosis II (Hunter syndrome). TV-enabled clinical development portfolio also includes DNL126 (ETV:SGSH) for mucopolysaccharidosis IIIA (Sanfilippo syndrome type A), DNL593 (PTV:PGRN) for frontotemporal dementia-granulin, DNL628 (OTV:MAPT) for Alzheimer’s disease, and DNL952 (ETV:GAA) for Pompe disease. It is also pursuing opportunities in other disease areas including oncology.

What is the price predicton of DNLI Stock?

Wall Street analysts forecast DNLI stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for DNLI is32.78 USD with a low forecast of 25.00 USD and a high forecast of 40.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Denali Therapeutics Inc (DNLI)'s revenue for the last quarter?

Denali Therapeutics Inc revenue for the last quarter amounts to 0.00 USD, decreased

What is Denali Therapeutics Inc (DNLI)'s earnings per share (EPS) for the last quarter?

Denali Therapeutics Inc. EPS for the last quarter amounts to -0.73 USD, increased 8.96

How many employees does Denali Therapeutics Inc (DNLI). have?

Denali Therapeutics Inc (DNLI) has 503 emplpoyees as of April 30 2026.

What is Denali Therapeutics Inc (DNLI) market cap?

Today DNLI has the market capitalization of 2.95B USD.