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APGE Overview

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ET
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Intellectia

Loading chart...

High
82.490
Open
78.220
VWAP
80.54
Vol
1.42M
Mkt Cap
6.19B
Low
77.000
Amount
114.15M
EV/EBITDA(TTM)
--
Total Shares
75.39M
EV
4.81B
EV/OCF(TTM)
--
P/S(TTM)
--
Apogee Therapeutics, Inc. is a clinical-stage biotechnology company. The Company is advancing novel biologics with the potential for differentiated efficacy and dosing in the inflammatory and immunology (I&I) markets, including for the treatment of atopic dermatitis (AD), asthma, eosinophilic esophagitis (EoE), chronic obstructive pulmonary disease (COPD), and other I&I indications. APG777, the Company’s most advanced program, is being initially developed for the treatment of AD. With four validated targets in its portfolio, it is seeking to achieve efficacy and dosing through monotherapies and combinations of its novel antibodies. Its most advanced programs are APG777, APG990, APG333, and APG808. APG990 is an SQ extended half-life mAb that utilizes advanced antibody engineering to target OX40L. APG333 is a fully human mAb against thymic stromal lymphopoietin (TSLP). APG808 is an SQ extended half-life mAb targeting IL-4Ra. APG279 is for the dual inhibition of OX40L and IL-13.
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Events Timeline

(ET)
2026-05-27
06:40:00
Apogee Therapeutics Enters $1.3B Financing Collaboration with Blackstone
select
2026-05-27
06:40:00
Apogee Therapeutics Reports Positive APEX Trial Data
select
2026-03-25 (ET)
2026-03-25
16:30:00
Major Averages Rise on U.S. Iran Peace Plan
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2026-03-25
12:10:00
U.S. Offers Iran 15-Point Peace Plan, Oil Prices Drop
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2026-03-25
06:10:00
Jefferies, TD Cowen, Stifel and Guggenheim Jointly Manage Offering
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News

NASDAQ.COM
8.5
05-29NASDAQ.COM
Regulatory Approvals and Collaborations in Biotech Sector
  • FDA Approval for AZN: AstraZeneca (AZN) secured FDA approval for the IMFINZI + BCG combination in high-risk non-muscle-invasive bladder cancer, supported by Phase 3 POTOMAC data showing a 32% reduction in recurrence or death, enhancing its competitive edge in oncology.
  • JNJ TREMFYA Label Expansion: Johnson & Johnson (JNJ) received FDA approval to add structural joint-damage inhibition data to the TREMFYA label for active psoriatic arthritis, confirming its unique position in first-line treatment with no new safety signals, reinforcing its market leadership.
  • LINZESS Approved for Children: Ironwood Pharmaceuticals (IRWD) gained FDA approval for LINZESS to treat functional constipation in children aged 2-5, based on a 12-week Phase 3 trial showing significant improvement in spontaneous bowel movements, expanding its pediatric market influence.
  • AbbVie's DECNUPAZ Approval: AbbVie (ABBV) received FDA approval for DECNUPAZ to treat ultra-rare blood cancer BPDCN, supported by Phase 1 data showing a 69.7% composite complete response rate and a median duration of 9.7 months, marking a significant innovation in hematologic oncology.
NASDAQ.COM
9.5
05-28NASDAQ.COM
Wedbush Raises Apogee Therapeutics Price Target to $135 Amid Positive Trial Results
  • Clinical Trial Success: Apogee Therapeutics' Phase 2 APEX trial results show that Zumilokibart met both primary and secondary endpoints, with 65.9% of patients in the mid-dose group achieving an EASI score of 75, indicating significant clinical efficacy and paving the way for a Phase 3 trial launch in the second half of 2026.
  • Price Target Increase: Wedbush analyst David Nierengarten raised the 12-month price target for Apogee from $120 to $135, suggesting that the current stock price presents a buying opportunity, reflecting optimistic market expectations for its new therapies.
  • Strategic Financing Collaboration: The company announced a strategic financing collaboration with Blackstone Life Sciences for up to $1.3 billion in flexible, non-dilutive capital to support the ongoing development and potential commercialization of Zumilokibart, enhancing the company's financial stability.
  • Financial Position: As of March 31, 2026, Apogee reported cash and cash equivalents of $1.3 billion, and despite an expanded net loss of $74.11 million in Q1, the funding is expected to sustain operations into 2029, demonstrating effective financial management.
seekingalpha
9.0
05-27seekingalpha
Apogee Secures $1.3B Financing to Advance Skin Therapy
  • Clinical Trial Results: Apogee Therapeutics' zumilokibart met all primary and secondary endpoints in a phase 2 trial for atopic dermatitis, with 61.6% of high-dose patients achieving EASI-75, indicating significant efficacy despite a negative market reaction.
  • Financing Progress: The company secured up to $1.3 billion in financing from Blackstone to support the advancement of zumilokibart into phase 3 trials, providing robust financial backing for future research and development.
  • Efficacy Comparison: In terms of EASI-75 scores, both high and mid-dose groups showed similar efficacy at 61.6% and 65.9%, respectively, while only 23.4% of the placebo group achieved this metric, highlighting the drug's effectiveness.
  • Secondary Endpoint Achievement: The mid-dose group also met several secondary endpoints, including IGA 0/1 response and EASI-90 response, further validating its potential in treating atopic dermatitis.
NASDAQ.COM
8.5
05-27NASDAQ.COM
Apogee Therapeutics Reports Positive Phase 2 APEX Trial Data for Zumilokibart
  • Clinical Trial Success: Apogee Therapeutics announced that its Phase 2 APEX trial showed positive 16-week data for mid-dose zumilokibart, with 65.9% of patients achieving EASI-75, indicating its potential as a best-in-class anti-IL-13 antibody for moderate-to-severe atopic dermatitis.
  • Dose Optimization Plan: Following these results, Apogee plans to advance the mid-dose into Phase 3 trials in the second half of 2026, as it demonstrated the best clinical activity and tolerability among the three doses tested, which is crucial for future drug development.
  • Strategic Financing Collaboration: The company has secured a $1.3 billion strategic financing partnership with Blackstone Life Sciences, expected to fund the commercialization of zumilokibart for atopic dermatitis, asthma, and eosinophilic esophagitis, thereby strengthening its financial position and market competitiveness.
  • Stock Market Performance: In pre-market trading on Wednesday, Apogee's shares were priced at $53.76 on the NYSE, reflecting a 4.93% increase, indicating positive market sentiment towards its clinical data and future prospects.
NASDAQ.COM
8.5
05-27NASDAQ.COM
Apogee Therapeutics Secures Up to $1.3 Billion Financing Partnership with Blackstone
  • Financing Partnership: Apogee Therapeutics has entered into a financing partnership with Blackstone Life Sciences that could provide up to $1.3 billion in non-dilutive capital to advance its lead drug candidate, zumilokibart, indicating strong financial backing for drug development.
  • Contract Details: The agreement includes up to $800 million in synthetic royalty financing and up to $500 million in senior debt financing, with Blackstone receiving low-to-mid single-digit royalties on global sales of zumilokibart for 15 years, which will decline as sales increase and be eliminated once annual sales exceed $8 billion.
  • Funding Allocation Plan: Apogee expects to receive the first $400 million in pre-approval funding, including a $100 million upfront payment, another $100 million tied to the completion of Phase 3 enrollment, and $200 million upon positive Phase 3 data, providing crucial financial support for its clinical trials.
  • Clinical Trial Progress: Apogee also reported positive results from Part B of its Phase 2 APEX study for moderate-to-severe atopic dermatitis, achieving both primary and secondary endpoints with high statistical significance, and plans to initiate Phase 3 studies in the second half of 2026, further enhancing its market prospects.
seekingalpha
8.5
05-27seekingalpha
Apogee Therapeutics Partners with Blackstone for $1.3B Financing
  • Financing Collaboration: Apogee Therapeutics has entered into a strategic financing collaboration with Blackstone Life Sciences, providing up to $1.3 billion in flexible, non-dilutive capital, including $800 million in synthetic royalty funding and $500 million in senior debt, aimed at supporting the development and commercialization of its advanced drug, zumilokibart.
  • Royalty Structure: Blackstone will provide up to $800 million in synthetic royalty funding in exchange for low-to-mid single-digit tiered royalties on worldwide annual sales of zumilokibart for a term of 15 years, which is expected to generate long-term revenue for the company.
  • Improved Cash Flow Outlook: As a result of this financing agreement, Apogee has removed its cash runway end date guidance, and combined with its current total cash of $1.3 billion, this transaction positions the company to achieve a self-sustainable financial profile without the need for future equity financing.
  • Market Reaction: Despite the significant funding support from the agreement, the market reacted negatively, with Apogee's shares falling over 27% in premarket trading, indicating investor concerns regarding the company's future prospects.
Wall Street analysts forecast APGE stock price to rise
15 Analyst Rating
Wall Street analysts forecast APGE stock price to rise
13 Buy
2 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
83.00
Averages
105.67
High
137.00
Current: 0.000
sliders
Low
83.00
Averages
105.67
High
137.00
Goldman Sachs
Early Stage Biotech -> Neutral
downgrade
$89
AI Analysis
2026-05-28
New
Reason
Goldman Sachs
Price Target
$89
AI Analysis
2026-05-28
New
downgrade
Early Stage Biotech -> Neutral
Reason
Goldman Sachs moved Apogee Therapeutics to a Neutral rating from Early Stage Biotech, with a 12-month price target of $89, after the company disclosed 16-week Phase 2 Part B dose optimization data from long-acting anti-IL-13 zumilokibart in moderate-to-severe atopic dermatitis. The higher dose evaluated did not lead to increased efficacy compared to the mid dose, partially contributing to share weakness in addition primarily to a lessened perceived view of near-term M&A interest post the Blackstone (BX) financing agreement, says the analyst. However, the firm was \"encouraged\" that the mid dose replicated the primary endpoint of EASI-75 observed in prior data, and by the improved outcomes on \"more stringent endpoints\" of vIGA 0/1 and EASI-90, the analyst tells investors.
Truist
Danielle Brill
Hold
maintain
$83 -> $81
2026-05-27
New
Reason
Truist
Danielle Brill
Price Target
$83 -> $81
2026-05-27
New
maintain
Hold
Reason
Truist analyst Danielle Brill lowered the firm's price target on Apogee Therapeutics to $81 from $83 and keeps a Hold rating on the shares. The firm's views on the company's Part B data remain largely unchanged following this morning's call. In short, while the results fell short of elevated expectations, Truist sees the overall dataset as supportive of zumi's efficacy and safety profile in atopic dermatitis. With added clinical validation, the firm raised its modeled probability of success to 75% from 70% and incorporate the impact of the Blackstone synthetic royalty agreement.
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Valuation Metrics

The current forward P/E ratio for Apogee Therapeutics Inc (APGE.O) is 0.00, compared to its 5-year average forward P/E of -12.33. For a more detailed relative valuation and DCF analysis to assess Apogee Therapeutics Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-12.33
Current PE
0.00
Overvalued PE
-7.92
Undervalued PE
-16.73

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-6.72
Current EV/EBITDA
0.00
Overvalued EV/EBITDA
-2.10
Undervalued EV/EBITDA
-11.34

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
191.08
Current PS
547.57
Overvalued PS
667.36
Undervalued PS
-285.20

Financials

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Whales Holding APGE

N
Novo Holdings A/S
Holding
APGE
+20.39%
3M Return
F
Fairmount Funds Management LLC
Holding
APGE
+17.03%
3M Return
A
Avoro Capital Advisors LLC
Holding
APGE
+15.03%
3M Return
D
Driehaus Capital Management LLC
Holding
APGE
+14.26%
3M Return
M
Mercer Global Advisors Inc.
Holding
APGE
+13.41%
3M Return
V
VR Management, LLC
Holding
APGE
+12.64%
3M Return

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Frequently Asked Questions

What is Apogee Therapeutics Inc (APGE) stock price today?

The current price of APGE is 82.14 USD — it has increased 5.55

What is Apogee Therapeutics Inc (APGE)'s business?

Apogee Therapeutics, Inc. is a clinical-stage biotechnology company. The Company is advancing novel biologics with the potential for differentiated efficacy and dosing in the inflammatory and immunology (I&I) markets, including for the treatment of atopic dermatitis (AD), asthma, eosinophilic esophagitis (EoE), chronic obstructive pulmonary disease (COPD), and other I&I indications. APG777, the Company’s most advanced program, is being initially developed for the treatment of AD. With four validated targets in its portfolio, it is seeking to achieve efficacy and dosing through monotherapies and combinations of its novel antibodies. Its most advanced programs are APG777, APG990, APG333, and APG808. APG990 is an SQ extended half-life mAb that utilizes advanced antibody engineering to target OX40L. APG333 is a fully human mAb against thymic stromal lymphopoietin (TSLP). APG808 is an SQ extended half-life mAb targeting IL-4Ra. APG279 is for the dual inhibition of OX40L and IL-13.

What is the price predicton of APGE Stock?

Wall Street analysts forecast APGE stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for APGE is105.67 USD with a low forecast of 83.00 USD and a high forecast of 137.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Apogee Therapeutics Inc (APGE)'s revenue for the last quarter?

Apogee Therapeutics Inc revenue for the last quarter amounts to -82.77M USD, increased 31.18

What is Apogee Therapeutics Inc (APGE)'s earnings per share (EPS) for the last quarter?

Apogee Therapeutics Inc. EPS for the last quarter amounts to -55570000.00 USD, increased 5.26

How many employees does Apogee Therapeutics Inc (APGE). have?

Apogee Therapeutics Inc (APGE) has 261000 emplpoyees as of May 31 2026.

What is Apogee Therapeutics Inc (APGE) market cap?

Today APGE has the market capitalization of 6.19B USD.