What’s Causing the Decline in Korro Bio Stock (KRRO) Today?
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Nov 13 2025
0mins
Source: TipRanks
Clinical Trial Results: Korro Bio's KRRO-110 failed to meet its primary endpoint in a Phase 1/2a clinical trial for treating Alpha-1 Antitrypsin Deficiency, leading to a significant drop in stock price.
Company Restructuring: Following the trial failure, Korro Bio announced a 34% workforce reduction, a one-time charge of $2.4 million, and the resignation of its Chief Medical Officer, while shifting focus to a new candidate, KRRO-121.
Stock Performance: Korro Bio's stock plummeted 78.07% in pre-market trading, with a year-to-date decrease of 17.47% and a 36.78% drop over the past year.
Analyst Outlook: Despite recent setbacks, analysts maintain a Moderate Buy rating for Korro Bio, with an average price target of $93.50, indicating a potential upside of 197.58%.
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Analyst Views on KRRO
Wall Street analysts forecast KRRO stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for KRRO is 25.75 USD with a low forecast of 7.00 USD and a high forecast of 81.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.
8 Analyst Rating
0 Buy
8 Hold
0 Sell
Hold
Current: 11.690
Low
7.00
Averages
25.75
High
81.00
Current: 11.690
Low
7.00
Averages
25.75
High
81.00
About KRRO
Korro Bio, Inc. is a clinical-stage biopharmaceutical company. The Company discovers, develops, and commercializes genetic medicines based on editing ribonucleic acid (RNA), enabling treatment of both rare and highly prevalent diseases. The Company is generating a portfolio of differentiated programs that are designed to harness the body’s natural RNA editing process to effect a precise yet transient single base edit. By editing RNA instead of DNA, it is expanding the reach of genetic medicines. Using its oligonucleotide-based approach, the Company brings its medicines to patients by leveraging its proprietary platform. The Company’s first development candidate, KRRO-110, is in development as a potential treatment for Alpha-1 Antitrypsin Deficiency (AATD) that has the potential to be disease-modifying and provide a differentiated therapeutic option.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
Korro Bio's KRRO-121 Receives Strong Analyst Upgrades
- Analyst Upgrades: H.C. Wainwright upgraded Korro Bio to ‘Buy’ from ‘Neutral’ with a $20 price target, asserting that KRRO-121 serves as an independently risk-mitigated asset, thereby enhancing market confidence in the stock.
- Stock Price Surge: Shares of Korro Bio jumped 13% on Thursday following optimistic upgrades from multiple analysts, indicating strong market confidence in the new drug development candidate KRRO-121, which is likely to attract more investor interest.
- Clinical Trial Plans: Korro intends to file for clinical trials of KRRO-121 in the second half of 2026, targeting hyperammonemia treatment, which could present new growth opportunities for the company in addressing this critical metabolic condition.
- Market Sentiment Shift: Retail sentiment on Stocktwits for KRRO stock shifted from ‘bearish’ to ‘extremely bullish’ in the past 24 hours, with message volume increasing from ‘high’ to ‘extremely high’, reflecting strong optimism among investors regarding the company’s prospects.
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Wall Street Analysts Adjust Ratings
- Analyst Rating Updates: Top Wall Street analysts have adjusted their ratings on several companies, reflecting a shift in market sentiment that could influence investor decisions and market trends.
- Overview of Changes: The rating changes include upgrades, downgrades, and new initiations, providing investors with a comprehensive view of market analysis to better seize investment opportunities.
- Investor Attention: The changes in analyst ratings may draw investor interest towards FTNT stock, particularly in the current market environment where investors need to closely monitor these shifts for informed decision-making.
- Market Impact Assessment: Analyst rating adjustments not only affect the performance of individual stocks but can also influence overall market sentiment, prompting investors to consider these factors to optimize their investment portfolios.
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