Zasocitinib Phase 3 Study Results: Takeda Pharmaceutical's Phase 3 studies of Zasocitinib for moderate-to-severe plaque psoriasis met all primary and ranked secondary endpoints, showing significant efficacy with over half of patients achieving clear skin by week 16.
Drug Mechanism and Safety: Zasocitinib is a selective oral tyrosine kinase 2 inhibitor that maintains 24-hour inhibition of IL-23, with a safety profile consistent with earlier trials and minimal off-target effects.
Study Details and Comparisons: The LATITUDE Phase 3 program included two studies with over 1,800 participants, demonstrating superiority over placebo and apremilast, with continued improvement in patient responses through week 24.
Future Plans and Market Impact: Takeda plans to submit a New Drug Application to the U.S. FDA in fiscal year 2026 and is advancing Zasocitinib in additional studies for other conditions, highlighting the company's strong pipeline and potential for revenue growth.
Wall Street analysts forecast TAK stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for TAK is 18.00 USD with a low forecast of 18.00 USD and a high forecast of 18.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.
1 Analyst Rating
Wall Street analysts forecast TAK stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for TAK is 18.00 USD with a low forecast of 18.00 USD and a high forecast of 18.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.
1 Buy
0 Hold
0 Sell
Moderate Buy
Current: 15.940
Low
18.00
Averages
18.00
High
18.00
Current: 15.940
Low
18.00
Averages
18.00
High
18.00
H.C. Wainwright
H.C. Wainwright
Buy
maintain
$97
2025-12-30
Reason
H.C. Wainwright
H.C. Wainwright
Price Target
$97
AI Analysis
2025-12-30
maintain
Buy
Reason
H.C. Wainwright says Xoma (XOMA) took "a nice ride down the creativity road again with nice pipeline expansion," after the company announced an expanded relationship with partner Takeda (TAK). The deal with Takeda is highlighted by no cash out from Xoma for bringing in nine assets, the firm notes. This was accomplished by only marginally reducing Xoma's royalty/milestone share in Takeda's mezagitamab. Wainwright maintains its positive view here on the depth and breadth of Xoma's partnered assets as well as the ongoing creativity of transaction the company consummates, and looks forward to a transactional and royalty growing 2026. The firm has a Buy rating on Xoma with a price target of $97 on the shares.
JPMorgan
Neutral
maintain
$34 -> $35
2025-09-09
Reason
JPMorgan
Price Target
$34 -> $35
2025-09-09
maintain
Neutral
Reason
JPMorgan raised the firm's price target on Alkermes (ALKS) to $35 from $34 and keeps a Neutral rating on the shares. The firm sees see alixorexton as well-positioned in narcolepsy type I based on detailed results from the Phase II Vibrance-1 study. Alixorexton delivered a profile broadly inline with expectations with efficacy that generally looks better than Takeda's (TAK) Phase III data for oveporexton, the analyst tells investors in a research note. JPMorgan upped its probability of sucess for alixorexton in narcolepsy type I to 75% from 70% following the data.
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Needham
Buy
downgrade
$45 -> $43
2025-09-09
Reason
Needham
Price Target
$45 -> $43
2025-09-09
downgrade
Buy
Reason
Needham lowered the firm's price target on Alkermes (ALKS) to $43 from $45 and keeps a Buy rating on the shares following Phase 2 data from the Vibrance-1 study. The firm reduced aliorexton's peak market share in narcolepsy type I by 10% to reflect its safety profile of blurred vision adverse events. The events may dissuade some physicians from using aliorexton as their first choice, especially in narcolepsy type I, given Takeda's (TAK) first-to-market position, the analyst tells investors in a research note. However, Needham continues to see valuation upside for Alkermes, believing alixorexton can have meaningful market share.
BofA
BofA
Neutral
maintain
2025-07-21
Reason
BofA
BofA
Price Target
2025-07-21
maintain
Neutral
Reason
BofA keeps a Neutral rating on Alkermes (ALKS) after the company reported Phase 2 results from the Vibrance-1 study evaluating its orexin-receptor 2 agonist in narcolepsy type1 patients. The study validates ALKS2680 as an active drug in narcolepsy, the analyst tells investors in a research note. However, the press release provided limited details on effect size and safety, which leaves outstanding questions such as strength of the cataplexy data and competitiveness versus Takeda's (TAK) TAK-861, contends BofA. The firm cites the limited data disclosure to the stock's selloff today. Alkermes in morning trading is down 7% to $27.09.
About TAK
Takeda Pharmaceutical Co Ltd is a Japan-based company mainly engaged in the research and development, manufacture, sale and licensing of pharmaceuticals. The Company focuses on the main business areas of gastrointestinal diseases, rare diseases, plasma derivatives (immune diseases), oncology (cancer), and neuroscience (neuropsychiatric diseases). The Company focuses on three research and development areas: innovative biopharmaceuticals with the focus on gastrointestinal and inflammatory diseases, neuroscience, and oncology, plus plasma derivatives and vaccines. Most of the pharmaceuticals treat rare diseases in the focus disease areas and the plasma derivatives area. The Company operates in Japan, the United States, Europe, and China.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
