SINO BIOPHARM's TQA3605 'Core Protein Allosteric Modulator' for Chronic Hepatitis B Meets Primary Endpoint in Phase II Clinical Trials
Clinical Trial Success: SINO BIOPHARM's TQA3605 tablets, a Class I innovative drug for chronic hepatitis B, have successfully completed Phase II clinical trials, meeting the primary endpoint.
Safety Profile: The drug demonstrated a favorable safety profile, with adverse reactions comparable to the control group and no new safety signals identified.
Unique Mechanism: TQA3605 is a Core Protein Allosteric Modulator (CpAM) that effectively suppresses multiple HBV genotypes without cross-resistance to nucleos(t)ide analogs (NAs).
Market Status: Currently, there are no approved CpAMs targeting HBV available in the global market.
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Hong Kong Stock Market Decline: Hong Kong stocks experienced a significant decline, with the HSI dropping 580 points (2.08%) to close at 27,387, while the HSCEI and HSTECH also fell by 2.5% and 2.1%, respectively, amid a total market turnover of $301.612 billion.
Gold and Resource Stocks Performance: Spot gold prices fell over 5%, impacting several gold mining stocks, which tumbled between 10-14%. Resource stocks like Jiangxi Copper and MMG also saw declines of 9-10%, with Jiangxi Copper's short selling ratio reaching 28.3%.
Pharmaceutical Sector Developments: CSPC Pharma's stock dropped 10.2% despite a partnership with AstraZeneca for innovative medicines, involving an upfront payment exceeding $9.3 billion. Other pharma stocks also faced declines ranging from 3.3% to 4.9%.
Corporate News and Market Rumors: CKH Holdings fell 4.6% following a court ruling on port contracts, while New World Development's share price rose 2.2% amid rumors of a potential change in ownership involving Blackstone.

Clinical Trial Success: SINO BIOPHARM's TQA3605 tablets, a Class I innovative drug for chronic hepatitis B, have successfully completed Phase II clinical trials, meeting the primary endpoint.
Safety Profile: The drug demonstrated a favorable safety profile, with adverse reactions comparable to the control group and no new safety signals identified.
Unique Mechanism: TQA3605 is a Core Protein Allosteric Modulator (CpAM) that effectively suppresses multiple HBV genotypes without cross-resistance to nucleos(t)ide analogs (NAs).
Market Status: Currently, there are no approved CpAMs targeting HBV available in the global market.

Market Performance: The HSI closed down 281 points (1.05%) at 26,563, with total market turnover at HKD225.689 billion. Major tech stocks like Tencent and Meituan also saw declines.
Smartphone Shipment Forecasts: Major smartphone manufacturers, including Xiaomi and OPPO, have lowered their annual shipment forecasts, impacting related stocks negatively.
Stock Movements: UBTECH Robotics surged 8.6% after a partnership with Airbus, while several other tech and pharmaceutical stocks experienced significant declines, with some dropping over 6%.
Economic Indicators: China's unemployment rate remained stable at 5.1% for December, slightly below the forecast of 5.2%, indicating potential weaknesses in domestic demand despite resilient exports.

Market Performance: The Hang Seng Index (HSI) fell by 281 points (1.0%) to close at 26,563, while the Hang Seng Tech Index (HSTI) and the Hang Seng China Enterprises Index (HSCEI) also experienced declines, with market turnover reaching $225.69 billion.
Active Heavyweights: Major stocks like Alibaba, Xiaomi, Meituan, Tencent, and Ping An saw declines, with Alibaba dropping 3.5% to $160.4 and Xiaomi down 1.7% to $36.48, amidst significant short selling activity.
Notable Movers: Sino Biopharma and Wuxi Biologics faced substantial losses, with declines of 6.2% and 4.8% respectively, while Sinopec Corp and Li Ning recorded gains, with Sinopec up 3.3% to $4.95.
High Volatility Stocks: Qunabox Group surged by 38.8% to $35, while Hao Tian International plummeted by 22.3% to $0.101, indicating significant volatility in smaller stocks within the market.

Market Overview: The HSI fell 1% to 26,579, with the HSCEI down 0.9% and the HSTECH decreasing by 1.1%, resulting in a total half-day turnover of $132.94 billion.
AI Stocks Performance: XTALPI saw a gain of 3.4%, while KINGSOFT CLOUD, INSILICO, GDS-SW, and UNISOUND experienced declines ranging from 2.7% to 5.6%.
Power Equipment Stocks: DONGFANG ELEC and HARBIN ELECTRIC both rose significantly, with increases of 6.6% and 7.3%, respectively, despite the overall market trend.
Pharmaceutical Sector Decline: Several pharmaceutical stocks, including SINO BIOPHARM and 3SBIO, faced declines of 4.6% to 6.1%, with WUXI APPTEC also dropping by 2.8%.

Market Performance: The Hang Seng Index (HSI) rose by 244 points (0.9%) to 27,092, while the Hang Seng Tech Index (HSTI) and the Hang Seng China Enterprises Index (HSCEI) also saw gains of 1.5% and 0.9%, respectively.
Active Heavyweights: Notable stock movements included Alibaba (BABA) up 5.3%, Tencent (TENCENT) up 1.7%, while Meituan (MEITUAN) fell by 3%.
Top Gainers: Ali Health surged by 15.9%, Haidilao increased by 7.4%, and Nongfu Spring rose by 6.1%, indicating strong performance among certain constituents.
Significant Movers: Synagistics saw a remarkable increase of 47.9%, while Dalipal Holdings experienced a decline of 12%. Other notable gainers included Q Tech and Chervon, both with gains exceeding 11%.





