Perspective Therapeutics Shares Latest Interim Results from Phase 1/2a Clinical Trial of [212Pb]VMT-α-NET at ESMO Congress 2025
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Oct 20 2025
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Source: Newsfilter
Clinical Trial Update: Perspective Therapeutics presented updated interim results for its Phase 1/2a trial of [^212Pb]VMT-α-NET at the ESMO Congress 2025, showing a 44% objective response rate in patients with SSTR2-expressing neuroendocrine tumors, with 14 out of 16 patients remaining free from disease progression.
Safety and Tolerability: The treatment was well-tolerated with no dose-limiting toxicities or serious treatment-related adverse events reported, reinforcing its potential as a safe option for patients with progressive neuroendocrine tumors.
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Analyst Views on CATX
Wall Street analysts forecast CATX stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for CATX is 11.82 USD with a low forecast of 4.00 USD and a high forecast of 18.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.
12 Analyst Rating
11 Buy
1 Hold
0 Sell
Strong Buy
Current: 4.260
Low
4.00
Averages
11.82
High
18.00
Current: 4.260
Low
4.00
Averages
11.82
High
18.00
About CATX
Perspective Therapeutics, Inc. is a radiopharmaceutical development company that is developing advanced treatment applications for cancers throughout the body. The Company has proprietary technology that utilizes the alpha-emitting isotope 212Pb to deliver powerful radiation specifically to cancer cells via specialized targeting moieties. It is also developing imaging diagnostics that incorporate the same targeting moieties, which provide the opportunity to personalize treatment and optimize patient outcomes. This theranostic approach enables the ability to see the specific tumor and then treat it to potentially improve efficacy and minimize toxicity. The Company's melanoma (VMT01) and neuroendocrine tumor (VMT-a-NET) programs have entered Phase I/IIa imaging and therapy trials for the treatment of metastatic melanoma and neuroendocrine tumors at several academic institutions. It has also developed a 212Pb generator to secure key isotopes for clinical trial and commercial operations.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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Perspective Therapeutics Updates VMT-α-NET Trial Results, 39% Patient Response Rate Achieved
- Clinical Trial Progress: Perspective Therapeutics presented updated results for VMT-α-NET at the ASCO-GI conference, revealing a 39% objective response rate among 23 patients, indicating the therapy's potential in treating unresectable neuroendocrine tumors.
- Safety Analysis: Among 56 treated patients, no dose-limiting toxicities (DLTs) were reported, and only 21 patients (37.5%) experienced grade 3 or higher treatment-related adverse events, demonstrating the therapy's favorable tolerability profile, which may support future clinical applications.
- Future Research Plans: The company plans to submit additional clinical data to medical conferences in 2026 and engage with regulatory agencies to advance VMT-α-NET into registrational trials, further validating its clinical efficacy.
- Dose Optimization: With the assessment of the 6.0 mCi dose cohort, Perspective has been cleared to enroll more patients, reflecting the company's ongoing progress in clinical trials and confidence in the new therapy, which could enhance its competitive position in the market.
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