Nurix Reports Bexobrutideg Clinical Data with 83% ORR in CLL Patients
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Dec 06 2025
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Source: Globenewswire
- Clinical Efficacy: In the ongoing Phase 1a study, Bexobrutideg achieved an 83% objective response rate (ORR) in patients with relapsed or refractory chronic lymphocytic leukemia (CLL), with a median progression-free survival (PFS) of 22.1 months, demonstrating significant efficacy and tolerability of the drug.
- Dose Optimization: In the Phase 1b study, the recommended dose of 600 mg showed an ORR of 83.3%, compared to 73.7% for the 200 mg dose, indicating that higher dosing may provide better clinical benefits for patients.
- Safety Assessment: Bexobrutideg exhibited good tolerability across all dose levels evaluated, with no dose-limiting toxicities reported, supporting its potential for future clinical development.
- Future Development: Nurix will further discuss these data in a webcast on December 8, 2025, marking the company's strong confidence in advancing the pivotal clinical development program for Bexobrutideg.
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Analyst Views on NRIX
Wall Street analysts forecast NRIX stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for NRIX is 28.93 USD with a low forecast of 12.00 USD and a high forecast of 41.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.
16 Analyst Rating
15 Buy
1 Hold
0 Sell
Strong Buy
Current: 17.590
Low
12.00
Averages
28.93
High
41.00
Current: 17.590
Low
12.00
Averages
28.93
High
41.00
About NRIX
Nurix Therapeutics, Inc. is a clinical-stage biopharmaceutical company. The Company is focused on the discovery, development and commercialization of targeted protein degradation medicines, which is aimed at improving treatment options for patients with cancer and inflammatory diseases. Its wholly owned, clinical-stage pipeline includes three investigational drug candidates: NX-5948, a highly selective degrader of Bruton’s tyrosine kinase (BTK); NX-2127, a dual degrader of BTK and transcription factors IKZF1(Ikaros) and IKZF3 (Aiolos); and NX-1607, an inhibitor of Casitas B-lineage lymphoma proto-oncogene B (CBL-B), an E3 ligase that regulates activation of multiple immune cell types including T cells and NK cells. The Company is also advancing multiple degraders and degrader antibody conjugates (DACs) in its preclinical pipeline. Its partnered drug discovery pipeline consists of preclinical stage degraders of IRAK4 and STAT6, as well as multiple additional programs.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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