NRx Amends NRX-101 Filing to Include TMS for Depression Treatment
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Dec 03 2025
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Source: Newsfilter
- Clinical Trial Progress: NRx has amended its Investigational New Drug filing for NRX-101 to include its use with Transcranial Magnetic Stimulation (TMS) for depression treatment, which is expected to significantly enhance treatment outcomes, particularly with a clinical response rate of 75% in suicidal depression patients.
- Market Potential: By 2030, over 1 million Americans are expected to receive TMS treatment annually, creating a substantial new market for NRX-101, which could significantly boost the company's revenue from previously unanticipated commercial opportunities.
- Efficacy Validation: Recent studies indicate that patients receiving D-cycloserine in conjunction with TMS experienced over a two-fold reduction in depressive symptoms, highlighting the drug's significant advantages in clinical applications and its potential to become a standard treatment option.
- Innovative Drug Combination: NRX-101 combines D-cycloserine with lurasidone, which is already approved for depression treatment, potentially reducing side effect risks and increasing patient acceptance, thereby further driving market recognition.
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Analyst Views on NRXP
Wall Street analysts forecast NRXP stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for NRXP is 37.67 USD with a low forecast of 25.00 USD and a high forecast of 48.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.
3 Analyst Rating
3 Buy
0 Hold
0 Sell
Strong Buy
Current: 2.110
Low
25.00
Averages
37.67
High
48.00
Current: 2.110
Low
25.00
Averages
37.67
High
48.00
About NRXP
NRx Pharmaceuticals, Inc. is a clinical-stage biopharmaceutical company developing therapeutics based on its N-methyl-D-aspartate (NMDA) platform for the treatment of central nervous system disorders, specifically suicidal depression, chronic pain, and PTSD. It is developing NRX-100 (preservative-free intravenous ketamine) and NRX-101, (oral D-cycloserine/lurasidone). NRX-100 has been awarded Fast Track Designation for the treatment of Suicidal Ideation in Depression, including Bipolar Depression. NRX-101 has been awarded Breakthrough Therapy Designation for the treatment of suicidal bipolar depression. NRx has filed an Abbreviated New Drug Application (ANDA) and initiated a New Drug Application filing for NRX-100 (IV ketamine) with an application for the Commissioner’s National Priority Voucher Program for the treatment of suicidal depression. Its subsidiary, HOPE Therapeutics, Inc., is a healthcare delivery company that is building a network of interventional psychiatry clinics.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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NRx Pharmaceuticals Licenses RWE from 70,000 Patients to Support NRX-100 FDA Approval
- Real World Evidence License: NRx Pharmaceuticals has licensed Real World Evidence from over 70,000 U.S. patients, a significant step toward FDA approval for its investigational drug NRX-100 (preservative-free ketamine), highlighting the company's strategic focus in mental health.
- Collaboration Platform: The data is sourced from Osmind, a neuropsychiatry technology platform widely used in U.S. clinics, providing detailed regulatory-grade patient records that enhance NRx's data support for FDA submissions.
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