Moleculin Biotech Announces 1-for-25 Reverse Stock Split, Reducing Outstanding Shares to 2.1 Million
- Reverse Stock Split Implementation: Moleculin Biotech announced a 1-for-25 reverse stock split effective December 1, 2025, reducing outstanding shares from approximately 51.7 million to about 2.1 million, aimed at increasing share price to meet Nasdaq listing requirements.
- Trading Impact: Post-split, Moleculin's common stock will open on the Nasdaq Capital Market under the new CUSIP number 60855D 408, and while facing challenges from reduced share circulation, the company hopes to enhance its market image through this action.
- Shareholder Rights Adjustment: The reverse stock split will not issue any fractional shares, and shareholders entitled to fractional shares will receive cash compensation, a measure intended to protect shareholder rights and simplify the shareholder structure.
- Increased Financing Needs: Moleculin anticipates requiring significant additional financing to support its clinical trials; while the reverse split may help boost share price, the company still faces uncertainties in securing funding to advance its drug development plans.
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Moleculin Biotech's 2026 MIRACLE Trial Data Unblinding Expected
- Clinical Trial Progress: Moleculin expects to complete the unblinding of data for 45 subjects in the MIRACLE trial in Q1 2026, which is anticipated to provide critical efficacy data for treating acute myeloid leukemia (AML), thereby enhancing Annamycin's market recognition.
- New Indication Expansion: Annamycin is set to initiate a clinical trial for pancreatic cancer in 2026, funded by Atlantic Health, based on preclinical data showing unexpected activity in pancreatic cancer models, further enhancing its market potential.
- Global Trial Network: The MIRACLE trial has expanded to nine countries, including the US and several European nations, with 46 trial sites selected, and is expected to recruit the 90th subject by Q1 2026, demonstrating the company's strong execution capabilities on a global scale.
- Significant Market Opportunity: Annamycin is poised to become the world's first non-cardiotoxic anthracycline, and given that nearly half of cancer patients currently use cardiotoxic drugs, the market demand potential is enormous, likely attracting increased investor interest.

Moleculin Stock Falls 17% Despite Encouraging Phase 1 WP1066 Results for Pediatric Brain Tumors
Stock Performance: Moleculin Biotech, Inc. (MBRX) shares fell 16.84% to $3.90 despite reporting positive results from a Phase 1 clinical trial of WP1066 for children with recurrent malignant brain tumors.
Clinical Trial Results: The trial indicated that the treatment was safe, induced anti-tumor immune responses, and suppressed STAT3 activity, showing promising signs in a challenging pediatric cancer context.
Market Reaction: Following the announcement, the stock experienced significant volatility and a steep sell-off, with trading activity exceeding average levels as investors reassessed the company's near-term risks.
Trading Range: MBRX's stock trades within a 52-week range of approximately $3.63 to $91.25, highlighting its volatility in the biotech market.






