Midday Stock Highlights: Notable Movements from Oracle, AST SpaceMobile, Revolution Medicines, and Others

Written by Emily J. Thompson, Senior Investment Analyst

Source: CNBC

Updated: Oct 17 2025

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Source: CNBC

AppFolio and Revolution Medicines Surge: AppFolio shares rose 7% after an upgrade, while Revolution Medicines jumped 10% following FDA approval for a cancer treatment.
AST SpaceMobile and Core Scientific Decline: AST SpaceMobile's shares fell 6% after a downgrade, and Core Scientific dropped over 5% amid investor opposition to its acquisition.
Mixed Results for State Street and Interactive Brokers: State Street's stock fell over 3% despite beating earnings expectations, while Interactive Brokers shares dropped 3% despite an earnings report that exceeded forecasts.
Pharmaceutical Stocks and Regional Banks Fluctuate: Novo Nordisk and Eli Lilly lost 3-4% after comments on drug pricing, while regional banks like Zions and Western Alliance saw gains following upgrades.

About the author

Emily J. Thompson

Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.