MetaVia's DA-1726 Clinical Trial Shows Significant Weight Loss Results
MetaVia announced positive statistically significant results from the 8-week non-titrated 48 mg, multiple ascending dose cohort of its Phase 1 clinical trial of DA-1726, a novel, dual oxyntomodulin, OXM, analog agonist that functions as a glucagon-like peptide-1 receptor and glucagon receptor, for the treatment of obesity. The results show robust early weight loss, statistically significant reductions in waist circumference, strong improvements in glucose control, and meaningful reductions in liver stiffness, alongside a favorable safety and tolerability profile. In the non-titrated 48 mg cohort, patients experienced no treatment-related discontinuations, and gastrointestinal events were mild to moderate in severity. By Day 26, patients receiving DA-1726 achieved a statistically significant average weight reduction of 6.1% and a statistically significant decrease in waist circumference of 5.8 cm. These improvements deepened through Day 54, with an average weight loss of 9.1% and a statistically significant 9.8 cm reduction in waist circumference. Patients also demonstrated a 12.3 mg/dL improvement in fasted glucose from a baseline of 105.3 mg/dL by Day 54. In addition, vibration-controlled transient elastography indicated a 23.7% reduction in liver stiffness from a baseline of 5.9 kPa, suggesting a significant direct hepatic effect from DA-1726.
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MetaVia Inc. Closes $9.3 Million Public Offering to Advance Obesity Treatment Development
- Funding Size: MetaVia Inc. has successfully closed a public offering raising approximately $9.3 million, which includes 3,005,574 shares of common stock and 4,508,361 Series C and D warrants, with proceeds aimed at advancing the clinical development of obesity treatment drug DA-1726, demonstrating the company's ongoing commitment to cardiometabolic diseases.
- Warrant Details: The Series C and D warrants were issued at a price of $3.10 per share, are immediately exercisable, with Series C warrants valid for five years and Series D for two years, potentially yielding up to $28 million in future proceeds if fully exercised, enhancing the company's financial flexibility.
- Underwriter Role: Ladenburg Thalmann & Co. Inc. acted as the sole book-running manager for the offering, ensuring a smooth fundraising process and reflecting market confidence in MetaVia's future growth prospects.
- Clinical Trial Outlook: MetaVia is conducting a Phase 1b clinical trial for DA-1726, and positive data could trigger the call option for Series D warrants, further enhancing the company's competitive position in the obesity treatment market.
MetaVia Inc. Closes $9.3 Million Public Offering to Advance Obesity Treatment Development
- Funding Amount: MetaVia Inc. has successfully closed a public offering raising approximately $9.3 million, which will be directed towards the clinical development of its obesity treatment drug DA-1726, demonstrating the company's ongoing commitment to cardiometabolic diseases.
- Shares and Warrants: The offering included 3,005,574 shares of common stock and 4,508,361 Series C and D warrants priced at $3.10 per share, indicating market confidence in its products and future potential.
- Future Revenue Potential: If the warrants are fully exercised, MetaVia could yield up to $28 million in future gross proceeds, providing substantial financial support for its research and operational needs.
- Underwriter Role: Ladenburg Thalmann & Co. Inc. acted as the sole book-running manager for this offering, showcasing its expertise and influence in the biotechnology financing sector.
