IDEAYA Biosciences Updates 2026 Corporate Objectives
IDEAYA Biosciences provided a business update including an overview of key corporate objectives for 2026. 2026 Corporate Objectives: Darovasertib in uveal melanoma - Topline results, including progression free survival data, from ongoing registrational Phase 2/3 OptimUM-02 trial of the darovasertib and crizotinib combination in first line patients with HLAA2-negative metastatic UM are expected in Q1 '26; Darovasertib is anticipated to be in three randomized, Phase 3 registrational trials across all stages of uveal melanoma by H1 '26; Complete enrollment of approximately 80 HLAA2-positive mUM patients in ongoing single-arm, Phase 2 OptimUM-01 trial of darovasertib in combination with crizotinib by Q2 '26. Antibody-drug Conjugate + DNA damage response combinations - IDE849: target to initiate a monotherapy registrational study in the second line/refractory setting of small cell lung cancer and/or neuroendocrine carcinomas by the end of 2026; IDE034: initiate Phase 1 dose escalation trial in Q1 '26; IDE161: initiate clinical combination studies with IDE849 in SCLC, NEC and other DLL3-overexpressing solid tumors in Q2 '26. MTAP Pathway - IDE397: provide updated data from Phase 1/2 combination trial with Trodelvy in MTAP-deleted urothelial cancer at a medical conference in 2026
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IDEAYA Biosciences Updates 2026 Corporate Objectives at J.P. Morgan Conference
- Pipeline Advancement: In 2025, IDEAYA successfully advanced multiple clinical projects, filing four INDs resulting in nine clinical programs, demonstrating the company's strong execution and readiness in the precision medicine oncology sector.
- Key Trial Plans: In 2026, IDEAYA plans to advance four registrational trials, including IDE849 as a monotherapy for neuroendocrine cancer and darovasertib for both pre-metastatic and metastatic uveal melanoma, aiming to improve patient prognosis and quality of life.
- Funding Assurance: The company expects its cash runway to support operations into 2030, ensuring the continued advancement of key combination therapies in high unmet need cancer areas, thereby enhancing its market competitiveness.
- Strategic Vision: IDEAYA is committed to developing targeted cancer therapies, particularly in the uveal melanoma space where FDA-approved treatments are lacking, showcasing its leadership and innovative potential in precision oncology.
IDEAYA Biosciences Updates 2026 Strategic Objectives, Plans to Advance Four Registrational Trials
- Advancement of Registrational Trials: IDEAYA plans to advance four registrational trials in 2026, including darovasertib for uveal melanoma, aimed at improving patient prognosis and addressing the lack of FDA-approved therapies.
- Clinical Data Release: Topline PFS data from the darovasertib and crizotinib combination is expected in Q1 2026, and if positive, will support a potential accelerated approval filing in the U.S., enhancing market competitiveness.
- Financial Assurance: As of September 30, 2025, IDEAYA has approximately $1.1 billion in cash and cash equivalents, expected to fund its operating plan into 2030, ensuring ongoing investment in R&D.
- New Drug Development: The company plans to initiate a registrational study for IDE849 targeting small cell lung cancer and neuroendocrine carcinomas by the end of 2026, showcasing its ongoing innovation in precision medicine.
