Explainer: What is the rationale behind considering leucovorin as a treatment for autism?

FDA Approval: The U.S. FDA approved a version of leucovorin by GlaxoSmithKline, which had previously been withdrawn from consideration, following a review related to its use in patients with cerebral folate deficiency, a condition linked to neurological symptoms and autism.

Leucovorin and Autism: While leucovorin is used off-label for autism treatment, studies suggest a potential link between low maternal folate levels and autism risk; however, the evidence supporting leucovorin's effectiveness in treating autism is considered weak and requires further research.