ENHANZE Expects Over 50% Royalty Revenue Growth in 2025
Consensus $1.34B. "Our increased multi-year guidance reflects both the strength of our core ENHANZE business and the exceptional momentum we built in 2025. In 2025, we expect royalty revenue growth to exceed 50% year-over-year, a clear demonstration of the strength of our business model and the durable demand for ENHANZE-enabled products globally. In parallel, we significantly expanded new partnerships, signing three new ENHANZE collaboration and licensing agreements, one new auto-injector commercial licensing and supply agreement and two auto-injector development agreements. In addition, our partner Janssen gained global approvals for Rybrevant Faspro, the tenth ENHANZE-approved product. During 2025, we advanced our strategic growth roadmap with the acquisitions of Elektrofi and their Hypercon technology and of Surf Bio and their hyperconcentration technology. Both hyperconcentration technologies have long-duration IP into the mid-2040s. Our operational accomplishments and acquisitions broaden our drug delivery portfolio and opportunity, amplify and extend our royalty horizons, and diversify the pathways through which we create value," said Helen Torley, president and CEO.
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Halozyme Updates Preliminary 2025 Financial Estimates and Raises 2026 Guidance
- 2025 Revenue Estimates: Halozyme anticipates total revenue of $1.385 to $1.4 billion for 2025, reflecting a year-over-year growth of 36% to 38%, indicating strong growth potential in its core business, particularly driven by sustained demand for patented products.
- 2026 Guidance Increase: The company raised its 2026 total revenue forecast to $1.71 to $1.81 billion, projecting a year-over-year growth of 23% to 30%, which underscores the robust growth of its royalty revenue expected to exceed $1 billion, growing by 30% to 35%.
- Acquisition of Surf Bio: Halozyme acquired Surf Bio for an upfront payment of $300 million, with potential milestone payments of up to $100 million, aiming to leverage its hyperconcentration technology to enhance the delivery efficiency of antibodies and biologics, thereby expanding its drug delivery market.
- New Collaboration Agreements: In 2025, Halozyme signed three new ENHANZE collaboration agreements along with multiple auto-injector commercial licensing agreements, demonstrating its strategic expansion and enhanced market penetration capabilities in the drug delivery sector.

Halozyme Raises 2026 Financial Guidance and Acquires Surf Bio
- 2025 Revenue Estimates: Halozyme anticipates total revenue for 2025 to reach between $1.385 billion and $1.4 billion, reflecting a year-over-year growth of 36% to 38%, which underscores the robust momentum of its core business in the biopharmaceutical sector.
- 2026 Financial Outlook: The company has raised its 2026 total revenue guidance to between $1.71 billion and $1.81 billion, with expected year-over-year growth of 23% to 30%, while projecting royalty revenue to exceed $1 billion, growing at 30% to 35%, indicating sustained market demand and a strong business model.
- Acquisition of Surf Bio: Halozyme acquired Surf Bio for an upfront payment of $300 million, with potential milestone payments up to $400 million, aimed at leveraging its innovative hyperconcentration technology to enhance the delivery of antibodies and biologics, thereby expanding its drug delivery portfolio.
- Strategic Partnership Expansion: In 2025, Halozyme signed three new ENHANZE collaboration agreements and multiple auto-injector development agreements, further strengthening its competitive position in drug delivery and laying the groundwork for future revenue growth.






