Compugen Secures $65 Million Upfront Payment in AstraZeneca Deal
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Dec 17 2025
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Source: Newsfilter
- Capital Injection: Compugen's agreement with AstraZeneca secures a $65 million upfront payment, with an additional $25 million contingent on the next milestone, significantly enhancing the company's financial position and extending its cash runway into 2029.
- Royalty Retention: By retaining the majority of future royalties, Compugen ensures potential earnings of up to $195 million from rilvegostomig's success, reflecting the company's confidence in the product and providing long-term value for shareholders.
- Pipeline Advancement: This transaction supports the advancement of Compugen's innovative immuno-oncology pipeline, enabling the company to continue developing unique therapeutic solutions while maintaining significant upside from rilvegostomig's potential success.
- Market Outlook: As a first-in-class dual-checkpoint inhibitor undergoing 11 Phase 3 trials, rilvegostomig presents substantial market opportunities for Compugen, further solidifying its leadership position in the cancer immunotherapy sector.
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Analyst Views on CGEN
Wall Street analysts forecast CGEN stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for CGEN is 4.00 USD with a low forecast of 4.00 USD and a high forecast of 4.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.
3 Analyst Rating
3 Buy
0 Hold
0 Sell
Strong Buy
Current: 1.950
Low
4.00
Averages
4.00
High
4.00
Current: 1.950
Low
4.00
Averages
4.00
High
4.00
About CGEN
Compugen Ltd. is a therapeutic discovery company. The Company focuses on infrastructure to discover drug targets and develop therapeutics. The Company is engaged in the research, development and commercialization of therapeutic and product candidates. The Company's pipeline primarily consists of early and preclinical stage immuno-oncology programs based on drug targets discovered by the Company, primarily immune checkpoint and myeloid protein target candidates. These programs are focused on the development of cancer immunotherapy drugs with potential to harness the immune system to provide treatment solutions in areas of unmet medical needs in various cancer types and patient populations, both as monotherapy and in combination with other drugs. Its pipeline also includes a preclinical stage fusion protein autoimmune product candidate. Its fields of focus are oncology and immunology, with emphasis on its discovery capabilities on immuno-oncology.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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Compugen Agrees with AstraZeneca to Monetize Future Royalties of Rilvegostomig
- Financial Strengthening: Compugen's agreement with AstraZeneca to monetize future royalties from rilvegostomig is expected to enhance its financial position, extending its cash runway into 2029 and providing ongoing support for its innovative immuno-oncology pipeline.
- Strategic Collaboration: The amended exclusive license agreement aims to bolster Compugen's capabilities in immuno-oncology, reflecting the significant potential value of rilvegostomig and further solidifying the company's market position in cancer treatment.
- Pipeline Expansion: Rilvegostomig, a PD-1/TIGIT bispecific antibody developed in collaboration with AstraZeneca, is currently in Phase 3 development, highlighting its importance in clinical trials and potential as a key future product.
- Innovative Platform Utilization: Compugen leverages its AI/ML-powered computational discovery platform (Unigen™) to identify novel drug targets, advancing the development of immunotherapies and showcasing the company's technological advantages and market potential in cancer treatment.
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