Biotech Stocks Rise for Vaxart and Precigen Following Q3 Earnings Reports
Vaxart's Financial Performance: Vaxart's shares rose ~11% after reporting Q3 revenue of $72.4M, exceeding forecasts by $32.3M, largely due to a BARDA contract. The company also noted a net loss per share of $0.04, reflecting a ~33% YoY contraction despite a significant increase in R&D expenses.
Precigen's Growth and FDA Approval: Precigen's shares surged ~27% following a strong Q3 performance with $2.9M in revenue, surpassing expectations and showing over 200% YoY growth, driven by collaboration and licensing revenue after FDA approval of its immunotherapy candidate, Papzimeos.
Patient Engagement for Papzimeos: Since receiving FDA approval in August, Precigen has registered over 100 patients in its Papzimeos Patient Hub, indicating strong early interest and rapid activation of its sales force.
Rising Costs for Both Companies: Both Vaxart and Precigen reported increased net losses per share, with Precigen's SG&A and R&D costs rising significantly, highlighting the financial pressures associated with their respective development activities.
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Precigen Announces PAPZIMEOS as New Standard of Care for RRP Treatment
- Standard of Care Shift: Precigen's consensus paper recommends PAPZIMEOS as the new first-line treatment for adults with recurrent respiratory papillomatosis (RRP), marking a significant shift from repeated surgeries to HPV-targeted immunotherapy, greatly enhancing treatment options for patients.
- Clinical Experience Backing: Authored by 16 leading physicians, the paper emphasizes the safety and efficacy of PAPZIMEOS based on extensive clinical experience and literature review, providing physicians with a clear treatment algorithm aimed at reducing surgical risks for patients.
- Significant Patient Impact: With approximately 27,000 adult RRP patients in the U.S., the FDA approval of PAPZIMEOS offers the first treatment addressing the root cause of the disease, potentially improving patients' quality of life and reducing healthcare burdens significantly.
- Multidisciplinary Care Advocacy: The paper underscores the importance of shared decision-making and multidisciplinary care, promoting early therapy to avoid the risks associated with repeated surgeries, thus providing a more comprehensive management strategy for RRP patients.

Precigen Receives FDA Approval for PAPZIMEOS, Surpassing 200 Patient Registrations
- Rapid Commercialization: Precigen's PAPZIMEOS, approved by the FDA in August 2025, is now being prescribed nationwide, with patient registrations doubling since November to over 200, reflecting strong market demand and enthusiastic physician engagement.
- Expanded Coverage: PAPZIMEOS is now covered by private health plans for approximately 170 million lives in the U.S., including most major insurers, and is also included under Medicare and Medicaid, significantly enhancing patient access.
- European Market Expansion: The European Medicines Agency has validated the Marketing Authorization Application for PAPZIMEOS, marking a significant step in Precigen's global expansion efforts, which is expected to create new growth opportunities for the company.
- Optimistic Financial Outlook: The company anticipates that its current capital resources will fund operations until cash flow break-even, and with the rapid rollout of PAPZIMEOS, there is substantial potential for future revenue growth, further solidifying its leadership in RRP treatment.









