Autolus Unveils New Phase I Results for Obe-cel in Challenging Lupus Cases
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Dec 09 2025
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Source: NASDAQ.COM
CARLYSLE Trial Update: Autolus Therapeutics presented updated clinical data from its CARLYSLE trial at the ASH Annual Meeting, focusing on the safety and efficacy of its CAR T-cell therapy, obe-cel, in patients with severe refractory systemic lupus erythematosus (SLE).
Efficacy Results: In the trial, half of the six patients receiving the 50M dose of obe-cel achieved a complete renal response, with 83% reaching remission based on DORIS criteria, while initial data from the 100M cohort suggests early improvements.
Next Steps: The findings support advancing obe-cel to a Phase 2 trial, named LUMINA, which is currently enrolling patients for further evaluation of its effectiveness in severe refractory lupus.
Market Performance: Autolus Therapeutics' stock closed at $1.59, reflecting a 2.58% increase, but saw a slight decline in premarket trading, indicating fluctuating investor interest following the trial updates.
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Analyst Views on AUTL
Wall Street analysts forecast AUTL stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for AUTL is 7.68 USD with a low forecast of 5.00 USD and a high forecast of 10.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.
5 Analyst Rating
5 Buy
0 Hold
0 Sell
Strong Buy
Current: 1.430
Low
5.00
Averages
7.68
High
10.00
Current: 1.430
Low
5.00
Averages
7.68
High
10.00
About AUTL
Autolus Therapeutics plc is a United Kingdom-based early commercial-stage biopharmaceutical company developing programmed T cell therapies for the treatment of cancer and autoimmune diseases. The Company has an approved commercial product, AUCATZYL, for the treatment of adult patients with r/r B-ALL. Using a suite of proprietary and modular T cell programming technologies, it is also developing five programs in seven hematological and solid tumor indications and one autoimmune indication. It is engineering precisely targeted, controlled and highly active T cell therapies that are designed to better recognize target cells, break down their defense mechanisms and attack and eliminate these cells. Its product pipeline includes obe-cel (ALLCAR19), obe-cel (CAROUSEL), AUTO1/22 (CARPALL), AUTO4 (LibrA T1), AUTO6 (MAGNETO), AUTO5, AUTO8 (MCARTY) and AUTO9. AUTO4 and AUTO5 are two programmed T cell therapies for the treatment of peripheral T-cell lymphoma targeting TRBC 1 and TRBC 2.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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